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Nap1l1 Gene Detail
Summary
  • Symbol
    Nap1l1
  • Name
    nucleosome assembly protein 1-like 1
  • Synonyms
    D10Ertd68e
  • Feature Type
    protein coding gene
  • IDs
    MGI:1855693
    NCBI Gene: 53605
  • Alliance
    gene page
  • Transcription Start Sites
    6 TSS
Location &
Maps
more
  • Sequence Map
    Chr10:111309084-111334011 bp, + strand
    From Ensembl annotation of GRCm39
  • View this region in JBrowse
  • Genome Browsers
    Ensembl | UCSC | NCBI
  • Genetic Map
    Chromosome 10, 58.67 cM
  • Mapping Data
    2 experiments
Strain
Comparison
more
  • SNPs within 2kb
    179 from dbSNP Build 142
  • Strain Annotations
    18
For selected strains:
Strain Gene Model ID Feature Type Coordinates Select Strains
C57BL/6J MGI_C57BL6J_1855693
 protein coding gene Chr10:111308754-111334011 (+)
129S1/SvImJ MGP_129S1SvImJ_G0017721
 protein coding gene Chr10:113890133-113919558 (+)
A/J MGP_AJ_G0017698
 protein coding gene Chr10:109561096-109586847 (+)
AKR/J MGP_AKRJ_G0017660
 protein coding gene Chr10:112761896-112786735 (+)
BALB/cJ MGP_BALBcJ_G0017662
 protein coding gene Chr10:109963003-109987586 (+)
C3H/HeJ MGP_C3HHeJ_G0017487
 protein coding gene Chr10:112912440-112937819 (+)
C57BL/6NJ MGP_C57BL6NJ_G0018119
 protein coding gene Chr10:117823939-117848878 (+)
CAROLI/EiJ MGP_CAROLIEiJ_G0015798
 protein coding gene Chr10:104422719-104447986 (+)
CAST/EiJ MGP_CASTEiJ_G0017048
 protein coding gene Chr10:113073312-113100271 (+)
CBA/J MGP_CBAJ_G0017456
 protein coding gene Chr10:122455233-122480176 (+)
DBA/2J MGP_DBA2J_G0017561
 protein coding gene Chr10:108697878-108721661 (+)
FVB/NJ MGP_FVBNJ_G0017555
 protein coding gene Chr10:107684649-107712657 (+)
LP/J MGP_LPJ_G0017635
 protein coding gene Chr10:114541582-114566785 (+)
NOD/ShiLtJ MGP_NODShiLtJ_G0017584
 protein coding gene Chr10:125063007-125088990 (+)
NZO/HlLtJ MGP_NZOHlLtJ_G0018157
 protein coding gene Chr10:112788779-112813555 (+)
PWK/PhJ MGP_PWKPhJ_G0016830
 protein coding gene Chr10:108778330-108803731 (+)
SPRET/EiJ MGP_SPRETEiJ_G0016620
 protein coding gene Chr10:111530186-111558717 (+)
WSB/EiJ MGP_WSBEiJ_G0017108
 protein coding gene Chr10:112916952-112941817 (+)



Homology
more
  • Human Ortholog
    NAP1L1, nucleosome assembly protein 1 like 1
  • Vertebrate Orthologs
    3
Vertebrate Orthology Source
Alliance of Genome Resources
  • Human Ortholog
    NAP1L1, nucleosome assembly protein 1 like 1
  • Synonyms
    NAP1, NAP1L, NRP
  • Links
    NCBI Gene ID: 4673
    neXtProt AC: NX_P55209
    UniProt: P55209

  • Chr Location
    12q21.2; chr12:76036585-76084735 (-)  GRCh38
Human Diseases
more
  • Diseases
    1 with human NAP1L1 associations

Human Disease Mouse Models
      
IDs
Click on a disease name to see all genes associated with that disease.

Mutations,
Alleles, and
Phenotypes
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  • Phenotype Summary
    4 phenotypes from 1 allele in 1 genetic background
    19 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
integument
immune system
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
neoplasm
vision/eye

Click cells to view annotations.
Mice homozygous for a homozygous mutation exhibit prenatal lethality and impaired neural progenitor cell proliferation and differentiation.
Gene Ontology
(GO)
Classifications
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  • All GO Annotations
    16
  • GO References
    8
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
RNA binding
signaling receptor activity
signaling receptor binding
transcription
transferase
transporter
Biological Process

carbohydrate derivative metabolism
cell differentiation
cell population proliferation
cellular component organization
DNA-templated transcription
establishment of localization
homeostatic process
immune system process
lipid metabolic process
programmed cell death
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
non-membrane-bounded organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
protein-containing complex
synapse
vacuole
Click cells to view annotations.
Expression
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Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
    759
  • Tissues
    46
  • cDNA Data
    30
  • Literature Summary
    4
Sequences &
Gene Models
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Representative SequencesLengthStrain/SpeciesFlank
genomic ENSMUSG00000058799 Ensembl Gene Model | MGI Sequence Detail 24928 C57BL/6J ±  kb
transcript ENSMUST00000065917 Ensembl | MGI Sequence Detail 1486 Not Applicable  
polypeptide ENSMUSP00000070068 Ensembl | MGI Sequence Detail 391 Not Applicable  
For the selected sequence
Protein
Information
less
Molecular
Reagents
less
  • All nucleic 33
    cDNA 30
    Primer pair 3

    Microarray probesets 11
Other
Accession IDs
less
MGI:1098627, MGI:2141803, MGI:2143550
References
more
  • Summaries
    All 56
    Developmental Gene Expression 4
    Gene Ontology 8
    Phenotypes 19
  • Earliest
    J:137335 Roderick TH, Chromosomal inversions in studies of mammalian mutagenesis. Genetics. 1979 May;92(1 Pt 1 Suppl):s121-6
  • Latest
    J:263406 Qiao H, et al., Nap1l1 Controls Embryonic Neural Progenitor Cell Proliferation and Differentiation in the Developing Brain. Cell Rep. 2018 Feb 27;22(9):2279-2293
Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
Citing These Resources
Funding Information
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Send questions and comments to User Support. 		last database update
04/09/2024
MGI 6.23 		The Jackson Laboratory