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Stag3 Gene Detail
Summary
  • Symbol
    Stag3
  • Name
    STAG3 cohesin complex component
  • Synonyms
    SA-2, stromalin 3
  • Feature Type
    protein coding gene
  • IDs
    MGI:1355311
    NCBI Gene: 50878
  • Alliance
    gene page
  • Transcription Start Sites
    4 TSS
Location &
Maps
more
  • Sequence Map
    Chr5:138278502-138310655 bp, + strand
    From Ensembl annotation of GRCm39
  • View this region in JBrowse
  • Genome Browsers
    Ensembl | UCSC | NCBI
  • Genetic Map
    Chromosome 5, 77.01 cM
  • Mapping Data
    3 experiments
Strain
Comparison
more
  • SNPs within 2kb
    73 from dbSNP Build 142
  • Strain Annotations
    18
  • PCR
    2
For selected strains:
Strain Gene Model ID Feature Type Coordinates Select Strains
C57BL/6J MGI_C57BL6J_1355311
 protein coding gene Chr5:138270757-138310659 (+)
129S1/SvImJ MGP_129S1SvImJ_G0030268
 protein coding gene Chr5:143130027-143168005 (+)
A/J MGP_AJ_G0030236
 protein coding gene Chr5:137009322-137043035 (+)
AKR/J MGP_AKRJ_G0030168
 protein coding gene Chr5:141381381-141419841 (+)
BALB/cJ MGP_BALBcJ_G0030250
 protein coding gene Chr5:138343714-138376157 (+)
C3H/HeJ MGP_C3HHeJ_G0029963
 protein coding gene Chr5:142104970-142143664 (+)
C57BL/6NJ MGP_C57BL6NJ_G0030697
 protein coding gene Chr5:148428111-148462671 (+)
CAROLI/EiJ MGP_CAROLIEiJ_G0027914
 protein coding gene Chr5:131028362-131061486 (+)
CAST/EiJ MGP_CASTEiJ_G0029369
 protein coding gene Chr5:141440834-141474417 (+)
CBA/J MGP_CBAJ_G0029934
 protein coding gene Chr5:154480013-154515432 (+)
DBA/2J MGP_DBA2J_G0030082
 protein coding gene Chr5:136902961-136935512 (+)
FVB/NJ MGP_FVBNJ_G0030040
 protein coding gene Chr5:136005133-136040048 (+)
LP/J MGP_LPJ_G0030171
 protein coding gene Chr5:143677067-143709313 (+)
NOD/ShiLtJ MGP_NODShiLtJ_G0030071
 protein coding gene Chr5:157232152-157275728 (+)
NZO/HlLtJ MGP_NZOHlLtJ_G0030738
 protein coding gene Chr5:141186548-141218477 (+)
PWK/PhJ MGP_PWKPhJ_G0029083
 protein coding gene Chr5:135869331-135932075 (+)
SPRET/EiJ MGP_SPRETEiJ_G0028918
 protein coding gene Chr5:138790691-138829777 (+)
WSB/EiJ MGP_WSBEiJ_G0029444
 protein coding gene Chr5:141874676-141906581 (+)



Homology
more
  • Human Ortholog
    STAG3, STAG3 cohesin complex component
  • Vertebrate Orthologs
    2
Vertebrate Orthology Source
Alliance of Genome Resources
  • Human Ortholog
    STAG3, STAG3 cohesin complex component
  • Synonyms
    SA3, SPGF61
  • Links
    NCBI Gene ID: 10734
    neXtProt AC: NX_Q9UJ98
    UniProt: Q9UJ98

  • Chr Location
    7q22.1; chr7:100177563-100219334 (+)  GRCh38
Human Diseases
more
  • Diseases
    2 with human STAG3 associations

Human Disease Mouse Models
      
IDs
IDs
Click on a disease name to see all genes associated with that disease.

Mutations,
Alleles, and
Phenotypes
less
  • Phenotype Summary
    14 phenotypes from 1 allele in 2 genetic backgrounds
    5 phenotypes from multigenic genotypes
    20 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
integument
immune system
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
neoplasm
vision/eye

Click cells to view annotations.
Mice homozygous for a transgenic gene disruption exhibit azoospermia and lack oocytes. Homozygous knockout affects chromosomal synapsis, cross-over and double-strand breaks during male meiosis.
Gene Ontology
(GO)
Classifications
less
  • All GO Annotations
    22
  • GO References
    13
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
RNA binding
signaling receptor activity
signaling receptor binding
transcription
transferase
transporter
Biological Process

carbohydrate derivative metabolism
cell differentiation
cell population proliferation
cellular component organization
DNA-templated transcription
establishment of localization
homeostatic process
immune system process
lipid metabolic process
programmed cell death
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
non-membrane-bounded organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
protein-containing complex
synapse
vacuole
Click cells to view annotations.
Expression
less
Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
    725
  • Tissues
    13
  • cDNA Data
    30
  • Literature Summary
    15
  • Comparison Matrix
    Gene Expression + Phenotype
    • Sequences &
    Gene Models
    less
    Representative SequencesLengthStrain/SpeciesFlank
    genomic ENSMUSG00000036928 Ensembl Gene Model | MGI Sequence Detail 32154 C57BL/6J ±  kb
    transcript ENSMUST00000162245 Ensembl | MGI Sequence Detail 4123 Not Applicable  
    polypeptide ENSMUSP00000125523 Ensembl | MGI Sequence Detail 1240 Not Applicable  
    For the selected sequence
    Protein
    Information
    less
    Molecular
    Reagents
    less
    • All nucleic 32
      cDNA 30
      Primer pair 2

      Microarray probesets 3
    References
    more
    • Summaries
      All 64
      Developmental Gene Expression 15
      Gene Ontology 13
      Phenotypes 20
    • Earliest
      J:60873 Pezzi N, et al., STAG3, a novel gene encoding a protein involved in meiotic chromosome pairing and location of STAG3-related genes flanking the Williams-Beuren syndrome deletion. FASEB J. 2000 Mar;14(3):581-92
    • Latest
      J:325094 Guan Y, et al., SCF ubiquitin E3 ligase regulates DNA double-strand breaks in early meiotic recombination. Nucleic Acids Res. 2022 May 20;50(9):5129-5144
    Contributing Projects:
    Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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    Funding Information
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    Send questions and comments to User Support.     		last database update
    04/09/2024
    MGI 6.23     		The Jackson Laboratory