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Fbxl12 Gene Detail
Summary
  • Symbol
    Fbxl12
  • Name
    F-box and leucine-rich repeat protein 12
  • Synonyms
    3110048D16Rik
  • Feature Type
    protein coding gene
  • IDs
    MGI:1354738
    NCBI Gene: 30843
  • Alliance
    gene page
  • Transcription Start Sites
    10 TSS
Location &
Maps
more
  • Sequence Map
    Chr9:20549045-20556064 bp, - strand
    From NCBI annotation of GRCm39
  • View this region in JBrowse
  • Genome Browsers
    Ensembl | UCSC | NCBI
  • Genetic Map
    Chromosome 9, 7.59 cM, cytoband A3
  • Mapping Data
    2 experiments
Strain
Comparison
more
  • SNPs within 2kb
    39 from dbSNP Build 142
  • Strain Annotations
    18
For selected strains:
Strain Gene Model ID Feature Type Coordinates Select Strains
C57BL/6J MGI_C57BL6J_1354738
 protein coding gene Chr9:20529414-20556064 (-)
129S1/SvImJ MGP_129S1SvImJ_G0034422
 protein coding gene Chr9:17765012-17788047 (-)
A/J MGP_AJ_G0034400
 protein coding gene Chr9:17483406-17507510 (-)
AKR/J MGP_AKRJ_G0034327
 protein coding gene Chr9:17801930-17825098 (-)
BALB/cJ MGP_BALBcJ_G0034391
 protein coding gene Chr9:17390230-17411627 (-)
C3H/HeJ MGP_C3HHeJ_G0034103
 protein coding gene Chr9:18117015-18138851 (-)
C57BL/6NJ MGP_C57BL6NJ_G0034912
 protein coding gene Chr9:18488643-18509078 (-)
CAROLI/EiJ MGP_CAROLIEiJ_G0031842
 protein coding gene Chr9:16623386-16643754 (-)
CAST/EiJ MGP_CASTEiJ_G0033426
 protein coding gene Chr9:17925097-17948784 (-)
CBA/J MGP_CBAJ_G0034076
 protein coding gene Chr9:19198770-19222030 (-)
DBA/2J MGP_DBA2J_G0034235
 protein coding gene Chr9:17483388-17504047 (-)
FVB/NJ MGP_FVBNJ_G0034178
 protein coding gene Chr9:16983241-17003751 (-)
LP/J MGP_LPJ_G0034320
 protein coding gene Chr9:17947003-17975026 (-)
NOD/ShiLtJ MGP_NODShiLtJ_G0034221
 protein coding gene Chr9:20836553-20859214 (-)
NZO/HlLtJ MGP_NZOHlLtJ_G0034932
 protein coding gene Chr9:17749507-17772206 (-)
PWK/PhJ MGP_PWKPhJ_G0033132
 protein coding gene Chr9:17444224-17464961 (-)
SPRET/EiJ MGP_SPRETEiJ_G0032966
 protein coding gene Chr9:17789315-17810907 (-)
WSB/EiJ MGP_WSBEiJ_G0033541
 protein coding gene Chr9:17480167-17502513 (-)



Homology
more
  • Human Ortholog
    FBXL12, F-box and leucine rich repeat protein 12
  • Vertebrate Orthologs
    2
Vertebrate Orthology Source
Alliance of Genome Resources
  • Human Ortholog
    FBXL12, F-box and leucine rich repeat protein 12
  • Synonyms
    Fbl12
  • Links
    NCBI Gene ID: 54850
    neXtProt AC: NX_Q9NXK8
    UniProt: Q9NXK8

  • Chr Location
    19p13.2; chr19:9810267-9827816 (-)  GRCh38
Mutations,
Alleles, and
Phenotypes
less
  • Phenotype Summary
    10 phenotypes from 1 allele in 1 genetic background
    7 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
integument
immune system
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
neoplasm
vision/eye

Click cells to view annotations.
Mice homozygous for a knock-out allele exhibit partial postnatal lethality, growth retardation, small placenta, absent gastric milk in mice that die and abnormal placental.
Gene Ontology
(GO)
Classifications
less
  • All GO Annotations
    6
  • GO References
    3
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
RNA binding
signaling receptor activity
signaling receptor binding
transcription
transferase
transporter
Biological Process

carbohydrate derivative metabolism
cell differentiation
cell population proliferation
cellular component organization
DNA-templated transcription
establishment of localization
homeostatic process
immune system process
lipid metabolic process
programmed cell death
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
non-membrane-bounded organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
protein-containing complex
synapse
vacuole
Click cells to view annotations.
Expression
less
Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
    737
  • Tissues
    10
  • cDNA Data
    13
  • Literature Summary
    1
  • Comparison Matrix
    Gene Expression + Phenotype
    • Sequences &
    Gene Models
    less
    Representative SequencesLengthStrain/SpeciesFlank
    genomic 30843 NCBI Gene Model | MGI Sequence Detail 7020 C57BL/6J ±  kb
    transcript NM_013911 RefSeq | MGI Sequence Detail 2126 C57BL/6  
    polypeptide Q9EPX5 UniProt | EBI | MGI Sequence Detail 326 Not Applicable  
    For the selected sequence
    Protein
    Information
    less
    Molecular
    Reagents
    less
    • All nucleic 15
      cDNA 14
      Primer pair 1

      Microarray probesets 5
    Other
    Accession IDs
    less
    MGI:1920456
    References
    more
    • Summaries
      All 30
      Developmental Gene Expression 1
      Gene Ontology 3
      Phenotypes 7
    • Earliest
      J:58149 Winston JT, et al., A family of mammalian F-box proteins. Curr Biol. 1999 Oct 21;9(20):1180-2
    • Latest
      J:280728 Zhao B, et al., Notch and the pre-TCR coordinate thymocyte proliferation by induction of the SCF subunits Fbxl1 and Fbxl12. Nat Immunol. 2019 Oct;20(10):1381-1392
    Contributing Projects:
    Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
    Citing These Resources
    Funding Information
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    Send questions and comments to User Support.     		last database update
    04/16/2024
    MGI 6.23     		The Jackson Laboratory