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Rgs3 Gene Detail
Summary
  • Symbol
    Rgs3
  • Name
    regulator of G-protein signaling 3
  • Synonyms
    4930506N09Rik, C2pa, C2PA-RGS3, PDZ-RGS3, RGS3S
  • Feature Type
    protein coding gene
  • IDs
    MGI:1354734
    NCBI Gene: 50780
  • Alliance
    genome feature page
  • Transcription Start Sites
    25 TSS
Location &
Maps
more
  • Sequence Map
    Chr4:62478079-62621256 bp, + strand
    From NCBI annotation of GRCm39
  • View this region in JBrowse
  • Genome Browsers
    Ensembl | UCSC | NCBI
  • Genetic Map
    Chromosome 4, 33.19 cM
  • Mapping Data
    2 experiments
Strain
Comparison
more
  • SNPs within 2kb
    3798 from dbSNP Build 142
  • Strain Annotations
    39
  • RFLP
    1
For selected strains:
Strain Gene Model ID Feature Type Coordinates Select Strains
C57BL/6J MGI_C57BL6J_1354734
 protein coding gene Chr4:62478079-62622238 (+)
129S1/SvImJ ENSMUSGG00200054760
 protein coding gene Chr4:57482653-57560694 (+)
129S1/SvImJ ENSMUSGG00200054881
 protein coding gene Chr4:57590390-57591173 (+)
129S1/SvImJ ENSMUSG00200002524
 protein coding gene Chr4:57599939-57604454 (+)
A/J ENSMUSG00195007932
 protein coding gene Chr4:58183446-58187962 (+)
A/J ENSMUSGG00195054904
 protein coding gene Chr4:58066142-58144192 (+)
A/J ENSMUSGG00195054891
 protein coding gene Chr4:58173889-58174672 (+)
AKR/J ENSMUSGG00220054867
 protein coding gene Chr4:57982181-57982964 (+)
AKR/J ENSMUSGG00220054761
 protein coding gene Chr4:57874446-57952486 (+)
AKR/J ENSMUSG00220005470
 protein coding gene Chr4:57991737-57996253 (+)
BALB/cJ ENSMUSG00180029925
 protein coding gene Chr4:57169303-57173819 (+)
BALB/cJ ENSMUSGG00180055101
 protein coding gene Chr4:57159747-57160530 (+)
BALB/cJ ENSMUSGG00180055382
 protein coding gene Chr4:57052005-57130045 (+)
C3H/HeJ ENSMUSGG00175054820
 protein coding gene Chr4:57942561-57943344 (+)
C3H/HeJ ENSMUSGG00175054818
 protein coding gene Chr4:57834813-57912864 (+)
C3H/HeJ ENSMUSG00175020571
 protein coding gene Chr4:57952112-57956627 (+)
C57BL/6NJ ENSMUSGG00215055668
 protein coding gene Chr4:58003788-58004571 (+)
C57BL/6NJ ENSMUSG00215024179
 protein coding gene Chr4:58013341-58017847 (+)
C57BL/6NJ ENSMUSGG00215055556
 protein coding gene Chr4:57896018-57974128 (+)
CAROLI/EiJ MGP_CAROLIEiJ_G0026086
 protein coding gene Chr4:56672323-56812253 (+)
CAST/EiJ no annotation
CBA/J ENSMUSG00210005401
 protein coding gene Chr4:57702775-57707290 (+)
CBA/J ENSMUSGG00210055036
 protein coding gene Chr4:57693227-57694010 (+)
CBA/J ENSMUSGG00210054813
 protein coding gene Chr4:57585482-57663535 (+)
DBA/2J ENSMUSGG00185057615
 protein coding gene Chr4:58109858-58110641 (+)
DBA/2J ENSMUSGG00185057614
 protein coding gene Chr4:58002126-58080164 (+)
DBA/2J ENSMUSG00185017101
 protein coding gene Chr4:58119405-58123920 (+)
FVB/NJ ENSMUSGG00205054474
 protein coding gene Chr4:56385450-56386233 (+)
FVB/NJ ENSMUSG00205015734
 protein coding gene Chr4:56395008-56399515 (+)
FVB/NJ ENSMUSGG00205054525
 protein coding gene Chr4:56277684-56355790 (+)
JF1/MsJ no annotation
LP/J ENSMUSGG00230055831
 protein coding gene Chr4:61492584-61570609 (+)
LP/J ENSMUSGG00230055832
 protein coding gene Chr4:61600302-61601085 (+)
LP/J ENSMUSG00230011169
 protein coding gene Chr4:61609850-61614365 (+)
NOD/ShiLtJ ENSMUSGG00190054803
 protein coding gene Chr4:56984149-57062227 (+)
NOD/ShiLtJ ENSMUSG00190032584
 protein coding gene Chr4:57101469-57105984 (+)
NOD/ShiLtJ ENSMUSGG00190055075
 protein coding gene Chr4:57091921-57092704 (+)
NZO/HlLtJ ENSMUSGG00225055431
 protein coding gene Chr4:66520845-66598880 (+)
NZO/HlLtJ ENSMUSG00225012737
 protein coding gene Chr4:66638121-66642636 (+)
NZO/HlLtJ ENSMUSGG00225055437
 protein coding gene Chr4:66628573-66629356 (+)
PWK/PhJ no annotation
SPRET/EiJ ENSMSPG00010028681
 protein coding gene Chr4:57553804-57637406 (+)
WSB/EiJ no annotation



Homology
more
  • Human Ortholog
    RGS3, regulator of G protein signaling 3
  • Vertebrate Orthologs
    4
Vertebrate Orthology Source
Alliance of Genome Resources
  • Human Ortholog
    RGS3, regulator of G protein signaling 3
  • Synonyms
    C2PA, RGP3
  • Links
    NCBI Gene ID: 5998
    UniProt: P49796

  • Chr Location
    9q32; chr9:113444730-113597743 (+)  GRCh38
Mutations,
Alleles, and
Phenotypes
less
  • Phenotype Summary
    7 phenotypes from 1 allele in 1 genetic background
    7 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
integument
immune system
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
neoplasm
vision/eye

Click cells to view annotations.
Mice homozygous for a targeted allele exhibit impaired T cell migration in model of Th2-mediated airway inflammation.
Gene Ontology
(GO)
Classifications
less
  • All GO Annotations
    19
  • GO References
    8
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
RNA binding
signaling receptor activity
signaling receptor binding
transcription
transferase
transporter
Biological Process

carbohydrate derivative metabolism
cell differentiation
cell population proliferation
cellular component organization
DNA-templated transcription
establishment of localization
homeostatic process
immune system process
lipid metabolic process
programmed cell death
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
membraneless organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
protein-containing complex
synapse
vacuole
Click cells to view annotations.
Expression
less
Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
    717
  • Tissues
    42
  • cDNA Data
    86
  • Literature Summary
    8
  • Comparison Matrix
    Gene Expression + Phenotype
    • Sequences &
    Gene Models
    less
    Representative SequencesLengthStrain/SpeciesFlank
    genomic 50780 NCBI Gene Model | MGI Sequence Detail 143178 C57BL/6J ±  kb
    transcript NM_019492 RefSeq | MGI Sequence Detail 4747 C57BL/6  
    polypeptide Q9DC04 UniProt | EBI | MGI Sequence Detail 966 Not Applicable  
    For the selected sequence
    Protein
    Information
    less
    Molecular
    Reagents
    less
    • All nucleic 96
      cDNA 88
      Primer pair 7
      Other 1
      Antibodies 1

      Microarray probesets 8
    Other
    Accession IDs
    less
    MGI:1889637, MGI:1921949
    References
    more
    • Summaries
      All 48
      Developmental Gene Expression 8
      Gene Ontology 8
      Phenotypes 7
    • Earliest
      J:31469 Druey KM, et al., Inhibition of G-protein-mediated MAP kinase activation by a new mammalian gene family. Nature. 1996 Feb 22;379(6567):742-6
    • Latest
      J:296441 Qiu R, et al., Spindle Orientation-Independent Control of Cell Fate Determination by RGS3 and KIF20A. Cereb Cortex Commun. 2020;1(1):tgaa003
    Contributing Projects:
    Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
    Citing These Resources
    Funding Information
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    Send questions and comments to User Support.     		last database update
    09/01/2026
    MGI 6.24     		The Jackson Laboratory