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Lsm4 Gene Detail
Summary
  • Symbol
    Lsm4
  • Name
    LSM4 homolog, U6 small nuclear RNA and mRNA degradation associated
  • Feature Type
    protein coding gene
  • IDs
    MGI:1354692
    NCBI Gene: 50783
  • Alliance
    genome feature page
  • Transcription Start Sites
    5 TSS
Location &
Maps
more
  • Sequence Map
    Chr8:71125898-71131402 bp, + strand
    From Ensembl annotation of GRCm39
  • View this region in JBrowse
  • Genome Browsers
    Ensembl | UCSC | NCBI
  • Genetic Map
    Chromosome 8, 34.15 cM
  • Mapping Data
    2 experiments
Strain
Comparison
more
  • SNPs within 2kb
    175 from dbSNP Build 142
  • Strain Annotations
    19
For selected strains:
Strain Gene Model ID Feature Type Coordinates Select Strains
C57BL/6J MGI_C57BL6J_1354692
 protein coding gene Chr8:71124663-71131402 (+)
129S1/SvImJ ENSMUSG00200025815
 protein coding gene Chr8:65923244-65928749 (+)
A/J ENSMUSG00195014111
 protein coding gene Chr8:66256727-66262231 (+)
AKR/J ENSMUSG00220021898
 protein coding gene Chr8:66168873-66174379 (+)
BALB/cJ ENSMUSG00180026013
 protein coding gene Chr8:65899641-65905147 (+)
C3H/HeJ ENSMUSG00175021276
 protein coding gene Chr8:66179608-66185114 (+)
C57BL/6NJ ENSMUSG00215036103
 protein coding gene Chr8:65859212-65864715 (+)
CAROLI/EiJ MGP_CAROLIEiJ_G0031158
 protein coding gene Chr8:62891856-62897657 (+)
CAST/EiJ ENSTCUG00005038533
 protein coding gene Chr8:65661129-65666616 (+)
CBA/J ENSMUSG00210031088
 protein coding gene Chr8:65945146-65950652 (+)
DBA/2J ENSMUSG00185011620
 protein coding gene Chr8:72104766-72110271 (+)
FVB/NJ ENSMUSG00205035838
 protein coding gene Chr8:65449383-65454888 (+)
JF1/MsJ ENSUMUG00000033913
 protein coding gene Chr8:74385072-74390560 (+)
LP/J ENSMUSG00230034323
 protein coding gene Chr8:75716288-75721793 (+)
NOD/ShiLtJ ENSMUSG00190019974
 protein coding gene Chr8:65866322-65871825 (+)
NZO/HlLtJ ENSMUSG00225045827
 protein coding gene Chr8:79125445-79130950 (+)
PWK/PhJ ENSLUMG00010033042
 protein coding gene Chr8:65842413-65847918 (+)
SPRET/EiJ ENSMSPG00010030064
 protein coding gene Chr8:67525662-67531170 (+)
WSB/EiJ ENSIUOG00005025661
 protein coding gene Chr8:66736378-66741884 (+)



Homology
more
  • Human Ortholog
    LSM4, LSM4 homolog, U6 small nuclear RNA and mRNA degradation associated
  • Vertebrate Orthologs
    3
Vertebrate Orthology Source
Alliance of Genome Resources
  • Human Ortholog
    LSM4, LSM4 homolog, U6 small nuclear RNA and mRNA degradation associated
  • Synonyms
    GRP, YER112W
  • Links
    NCBI Gene ID: 25804
    UniProt: Q9Y4Z0

  • Chr Location
    19p13.11; chr19:18306231-18323112 (-)  GRCh38
Mutations,
Alleles, and
Phenotypes
less
  • Phenotype Summary
    1 phenotype from 1 allele in 1 genetic background
    11 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
integument
immune system
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
neoplasm
vision/eye

Click cells to view annotations.
Embryos homozygous for a gene trap mutation in this gene die in the peri-implantation stage.
Gene Ontology
(GO)
Classifications
less
  • All GO Annotations
    32
  • GO References
    8
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
RNA binding
signaling receptor activity
signaling receptor binding
transcription
transferase
transporter
Biological Process

carbohydrate derivative metabolism
cell differentiation
cell population proliferation
cellular component organization
DNA-templated transcription
establishment of localization
homeostatic process
immune system process
lipid metabolic process
programmed cell death
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
membraneless organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
protein-containing complex
synapse
vacuole
Click cells to view annotations.
Expression
less
Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
    642
  • Tissues
    45
  • cDNA Data
    123
  • Literature Summary
    3
Sequences &
Gene Models
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Representative SequencesLengthStrain/SpeciesFlank
genomic ENSMUSG00000031848 Ensembl Gene Model | MGI Sequence Detail 5505 C57BL/6J ±  kb
transcript ENSMUST00000034311 Ensembl | MGI Sequence Detail 925 Not Applicable  
polypeptide ENSMUSP00000034311 Ensembl | MGI Sequence Detail 138 Not Applicable  
For the selected sequence
Protein
Information
less
Molecular
Reagents
less
  • All nucleic 125
    cDNA 123
    Primer pair 1
    Other 1

    Microarray probesets 3
References
more
  • Summaries
    All 42
    Developmental Gene Expression 3
    Gene Ontology 8
    Phenotypes 11
  • Earliest
    J:59997 Hirsch E, et al., Peri-implantation lethality in mice lacking the Sm motif-containing protein Lsm4. Mol Cell Biol. 2000 Feb;20(3):1055-62
  • Latest
    J:297867 Kim J, et al., USP15 Deubiquitinates TUT1 Associated with RNA Metabolism and Maintains Cerebellar Homeostasis. Mol Cell Biol. 2020 Oct 13;40(21)
Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
Citing These Resources
Funding Information
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Send questions and comments to User Support. 		last database update
09/08/2026
MGI 6.24 		The Jackson Laboratory