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Lcmt2 Gene Detail
Summary
  • Symbol
    Lcmt2
  • Name
    leucine carboxyl methyltransferase 2
  • Synonyms
    Tyw4
  • Feature Type
    protein coding gene
  • IDs
    MGI:1353659
    NCBI Gene: 329504
  • Alliance
    genome feature page
  • Transcription Start Sites
    4 TSS
Location &
Maps
more
  • Sequence Map
    Chr2:120967773-120971179 bp, - strand
    From NCBI annotation of GRCm39
  • View this region in JBrowse
  • Genome Browsers
    Ensembl | UCSC | NCBI
  • Genetic Map
    Chromosome 2, 60.37 cM
  • Mapping Data
    2 experiments
Strain
Comparison
more
  • SNPs within 2kb
    155 from dbSNP Build 142
  • Strain Annotations
    19
For selected strains:
Strain Gene Model ID Feature Type Coordinates Select Strains
C57BL/6J MGI_C57BL6J_1353659
 protein coding gene Chr2:120958788-120971179 (-)
129S1/SvImJ ENSMUSG00200046851
 protein coding gene Chr2:117890530-117902807 (-)
A/J ENSMUSG00195024452
 protein coding gene Chr2:117931445-117944342 (-)
AKR/J ENSMUSG00220037311
 protein coding gene Chr2:117854861-117867137 (-)
BALB/cJ ENSMUSG00180042110
 protein coding gene Chr2:117741907-117744964 (-)
C3H/HeJ ENSMUSG00175023422
 protein coding gene Chr2:118206766-118219119 (-)
C57BL/6NJ ENSMUSG00215013128
 protein coding gene Chr2:117877113-117889462 (-)
CAROLI/EiJ MGP_CAROLIEiJ_G0024182
 protein coding gene Chr2:113981280-113994501 (-)
CAST/EiJ ENSTCUG00005016837
 protein coding gene Chr2:117141848-117154186 (-)
CBA/J ENSMUSG00210007032
 protein coding gene Chr2:118047691-118060014 (-)
DBA/2J ENSMUSG00185045876
 protein coding gene Chr2:117729401-117742300 (-)
FVB/NJ ENSMUSG00205018961
 protein coding gene Chr2:116955497-116967787 (-)
JF1/MsJ ENSUMUG00000035635
 protein coding gene Chr2:117625321-117637672 (-)
LP/J ENSMUSG00230021373
 protein coding gene Chr2:119550143-119562422 (-)
NOD/ShiLtJ ENSMUSG00190041665
 protein coding gene Chr2:117975901-117988250 (-)
NZO/HlLtJ ENSMUSG00225003963
 protein coding gene Chr2:127463843-127466666 (-)
PWK/PhJ ENSLUMG00010043689
 protein coding gene Chr2:117517635-117530032 (-)
SPRET/EiJ ENSMSPG00010037813
 protein coding gene Chr2:119968705-119971161 (-)
WSB/EiJ ENSIUOG00005024721
 protein coding gene Chr2:117703509-117715853 (-)



Homology
more
  • Human Ortholog
    LCMT2, leucine carboxyl methyltransferase 2
  • Vertebrate Orthologs
    2
Vertebrate Orthology Source
Alliance of Genome Resources
  • Human Ortholog
    LCMT2, leucine carboxyl methyltransferase 2
  • Synonyms
    PPM2, TYW4
  • Links
    NCBI Gene ID: 9836
    UniProt: O60294

  • Chr Location
    15q15.3; chr15:43323649-43330582 (-)  GRCh38
Mutations,
Alleles, and
Phenotypes
less
  • Phenotype Summary
    6 phenotype references
Gene Ontology
(GO)
Classifications
less
  • All GO Annotations
    7
  • GO References
    4
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
RNA binding
signaling receptor activity
signaling receptor binding
transcription
transferase
transporter
Biological Process

carbohydrate derivative metabolism
cell differentiation
cell population proliferation
cellular component organization
DNA-templated transcription
establishment of localization
homeostatic process
immune system process
lipid metabolic process
programmed cell death
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
membraneless organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
protein-containing complex
synapse
vacuole
Click cells to view annotations.
Expression
less
Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
    597
  • cDNA Data
    32
Sequences &
Gene Models
less
Representative SequencesLengthStrain/SpeciesFlank
genomic 329504 NCBI Gene Model | MGI Sequence Detail 3407 C57BL/6J ±  kb
transcript NM_177846 RefSeq | MGI Sequence Detail 3407 C57BL/6  
polypeptide Q8BYR1 UniProt | EBI | MGI Sequence Detail 686 Not Applicable  
For the selected sequence
Protein
Information
less
Molecular
Reagents
less
  • All nucleic 32
    cDNA 32

    Microarray probesets 3
References
more
  • Summaries
    All 31
    Gene Ontology 4
    Phenotypes 6
  • Earliest
    J:109968 Roderick TH, et al., Nineteen paracentric chromosomal inversions in mice. Genetics. 1974 Jan;76(1):109-17
  • Latest
    J:380596 Li X, et al., USP24-dependent stabilization of Runx2 recruits a p300/NCOA3 complex to transactivate ADAMTS genes and promote degeneration of intervertebral disc in chronic inflammation mice. Biol Direct. 2023 Jul 6;18(1):37
Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
Citing These Resources
Funding Information
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Send questions and comments to User Support. 		last database update
09/08/2026
MGI 6.24 		The Jackson Laboratory