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Slc25a3 Gene Detail
Summary
  • Symbol
    Slc25a3
  • Name
    solute carrier family 25 (mitochondrial carrier, phosphate carrier), member 3
  • Synonyms
    5730556H19Rik, Phc
  • Feature Type
    protein coding gene
  • IDs
    MGI:1353498
    NCBI Gene: 18674
  • Alliance
    gene page
  • Transcription Start Sites
    5 TSS
Location &
Maps
more
  • Sequence Map
    Chr10:90952436-90959902 bp, - strand
    From NCBI annotation of GRCm39
  • View this region in JBrowse
  • Genome Browsers
    Ensembl | UCSC | NCBI
  • Genetic Map
    Chromosome 10, 45.60 cM
  • Mapping Data
    2 experiments
Strain
Comparison
more
  • SNPs within 2kb
    94 from dbSNP Build 142
  • Strain Annotations
    18
For selected strains:
Strain Gene Model ID Feature Type Coordinates Select Strains
C57BL/6J MGI_C57BL6J_1353498
 protein coding gene Chr10:90952436-90959921 (-)
129S1/SvImJ MGP_129S1SvImJ_G0017644
 protein coding gene Chr10:92405151-92413144 (-)
A/J MGP_AJ_G0017623
 protein coding gene Chr10:89200650-89208728 (-)
AKR/J MGP_AKRJ_G0017581
 protein coding gene Chr10:91762892-91770377 (-)
BALB/cJ MGP_BALBcJ_G0017586
 protein coding gene Chr10:89483465-89490950 (-)
C3H/HeJ MGP_C3HHeJ_G0017409
 protein coding gene Chr10:91781309-91788794 (-)
C57BL/6NJ MGP_C57BL6NJ_G0018043
 protein coding gene Chr10:95462443-95469928 (-)
CAROLI/EiJ MGP_CAROLIEiJ_G0015725
 protein coding gene Chr10:84870110-84877644 (-)
CAST/EiJ MGP_CASTEiJ_G0016974
 protein coding gene Chr10:91707073-91715352 (-)
CBA/J MGP_CBAJ_G0017378
 protein coding gene Chr10:99405051-99418640 (-)
DBA/2J MGP_DBA2J_G0017484
 protein coding gene Chr10:88323823-88332911 (-)
FVB/NJ MGP_FVBNJ_G0017476
 protein coding gene Chr10:87544636-87552424 (-)
LP/J MGP_LPJ_G0017558
 protein coding gene Chr10:93039262-93046747 (-)
NOD/ShiLtJ MGP_NODShiLtJ_G0017507
 protein coding gene Chr10:100863970-100871476 (-)
NZO/HlLtJ MGP_NZOHlLtJ_G0018080
 protein coding gene Chr10:91649492-91656977 (-)
PWK/PhJ MGP_PWKPhJ_G0016755
 protein coding gene Chr10:88379428-88390000 (-)
SPRET/EiJ MGP_SPRETEiJ_G0016543
 protein coding gene Chr10:90408282-90415741 (-)
WSB/EiJ MGP_WSBEiJ_G0017033
 protein coding gene Chr10:91620284-91627773 (-)



Homology
more
  • Human Ortholog
    SLC25A3, solute carrier family 25 member 3
  • Vertebrate Orthologs
    4
Vertebrate Orthology Source
Alliance of Genome Resources
  • Human Ortholog
    SLC25A3, solute carrier family 25 member 3
  • Synonyms
    OK/SW-cl.48, PHC, PiC, PTP
  • Links
    NCBI Gene ID: 5250
    neXtProt AC: NX_Q00325
    UniProt: Q00325

  • Chr Location
    12q23.1; chr12:98593591-98606379 (+)  GRCh38
Mutations,
Alleles, and
Phenotypes
less
  • Phenotype Summary
    16 phenotypes from 2 alleles in 2 genetic backgrounds
    21 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
integument
immune system
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
neoplasm
vision/eye

Click cells to view annotations.
Gene Ontology
(GO)
Classifications
less
  • All GO Annotations
    11
  • GO References
    10
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
RNA binding
signaling receptor activity
signaling receptor binding
transcription
transferase
transporter
Biological Process

carbohydrate derivative metabolism
cell differentiation
cell population proliferation
cellular component organization
DNA-templated transcription
establishment of localization
homeostatic process
immune system process
lipid metabolic process
programmed cell death
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
non-membrane-bounded organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
protein-containing complex
synapse
vacuole
Click cells to view annotations.
Expression
less
Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
    1143
  • Tissues
    182
  • cDNA Data
    697
  • Literature Summary
    6
  • Comparison Matrix
    Gene Expression + Phenotype
    • Sequences &
    Gene Models
    less
    Representative SequencesLengthStrain/SpeciesFlank
    genomic 18674 NCBI Gene Model | MGI Sequence Detail 7467 C57BL/6J ±  kb
    transcript NM_001428747 RefSeq | MGI Sequence Detail 1428 C57BL/6  
    polypeptide Q8VEM8 UniProt | EBI | MGI Sequence Detail 357 Not Applicable  
    For the selected sequence
    Protein
    Information
    less
    • UniProt
      6 Sequences
    • Protein Ontology
      PR:000015026 solute carrier family 25 member 3
      (term hierarchy)
    • InterPro Domains
      IPR023395 Mitochondrial carrier domain superfamily
      IPR044677 Mitochondrial phosphate carrier protein SLC25A3/Pic2/Mir1-like
      IPR018108 Mitochondrial substrate/solute carrier
    Molecular
    Reagents
    less
    • All nucleic 705
      cDNA 700
      Primer pair 4
      Other 1

      Microarray probesets 4
    Other
    Accession IDs
    less
    MGD-MRK-13291, MGI:1915351, MGI:97573
    References
    more
    • Summaries
      All 64
      Developmental Gene Expression 6
      Gene Ontology 10
      Phenotypes 21
    • Earliest
      J:137335 Roderick TH, Chromosomal inversions in studies of mammalian mutagenesis. Genetics. 1979 May;92(1 Pt 1 Suppl):s121-6
    • Latest
      J:335878 Montanes-Agudo P, et al., The RNA-binding protein QKI governs a muscle-specific alternative splicing program that shapes the contractile function of cardiomyocytes. Cardiovasc Res. 2023 May 22;119(5):1161-1174
    Contributing Projects:
    Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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    Funding Information
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    Send questions and comments to User Support.     		last database update
    04/09/2024
    MGI 6.23     		The Jackson Laboratory