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Meltf Gene Detail
Summary
  • Symbol
    Meltf
  • Name
    melanotransferrin
  • Synonyms
    CD228, melanotransferrin, Mfi2, MTf
  • Feature Type
    protein coding gene
  • IDs
    MGI:1353421
    NCBI Gene: 30060
  • Alliance
    genome feature page
  • Transcription Start Sites
    4 TSS
Location &
Maps
more
  • Sequence Map
    Chr16:31697628-31717838 bp, + strand
    From Ensembl annotation of GRCm39
  • View this region in JBrowse
  • Genome Browsers
    Ensembl | UCSC | NCBI
  • Genetic Map
    Chromosome 16, 22.40 cM, cytoband B3
  • Mapping Data
    2 experiments
Strain
Comparison
more
  • SNPs within 2kb
    619 from dbSNP Build 142
  • Strain Annotations
    19
For selected strains:
Strain Gene Model ID Feature Type Coordinates Select Strains
C57BL/6J MGI_C57BL6J_1353421
 protein coding gene Chr16:31697449-31717838 (+)
129S1/SvImJ ENSMUSG00200034665
 protein coding gene Chr16:28718090-28738302 (+)
A/J ENSMUSG00195027275
 protein coding gene Chr16:28269054-28289265 (+)
AKR/J ENSMUSG00220032100
 protein coding gene Chr16:28556994-28577223 (+)
BALB/cJ ENSMUSG00180028817
 protein coding gene Chr16:28484880-28505091 (+)
C3H/HeJ ENSMUSG00175034485
 protein coding gene Chr16:28624666-28644973 (+)
C57BL/6NJ ENSMUSG00215011614
 protein coding gene Chr16:28502833-28523043 (+)
CAROLI/EiJ MGP_CAROLIEiJ_G0020656
 protein coding gene Chr16:28875297-28895305 (+)
CAST/EiJ ENSTCUG00005033771
 protein coding gene Chr16:28893050-28914306 (+)
CBA/J ENSMUSG00210030296
 protein coding gene Chr16:28666679-28686986 (+)
DBA/2J ENSMUSG00185018484
 protein coding gene Chr16:28582165-28602472 (+)
FVB/NJ ENSMUSG00205021886
 protein coding gene Chr16:28600601-28620812 (+)
JF1/MsJ ENSUMUG00000018218
 protein coding gene Chr16:28756815-28777094 (+)
LP/J ENSMUSG00230025488
 protein coding gene Chr16:31150943-31171250 (+)
NOD/ShiLtJ ENSMUSG00190028116
 protein coding gene Chr16:28775947-28796159 (+)
NZO/HlLtJ ENSMUSG00225039655
 protein coding gene Chr16:34388393-34408605 (+)
PWK/PhJ ENSLUMG00010030665
 protein coding gene Chr16:28587696-28607934 (+)
SPRET/EiJ ENSMSPG00010017263
 protein coding gene Chr16:28572058-28590541 (+)
WSB/EiJ ENSIUOG00005030986
 protein coding gene Chr16:28748713-28768943 (+)



Homology
more
  • Human Ortholog
    MELTF, melanotransferrin
  • Vertebrate Orthologs
    3
Vertebrate Orthology Source
Alliance of Genome Resources
  • Human Ortholog
    MELTF, melanotransferrin
  • Synonyms
    CD228, MAP97, MFI2, MTf, MTF1
  • Links
    NCBI Gene ID: 4241
    UniProt: P08582

  • Chr Location
    3q29; chr3:196980590-197029874 (-)  GRCh38
Mutations,
Alleles, and
Phenotypes
less
  • Phenotype Summary
    2 phenotypes from 1 allele in 1 genetic background
    15 phenotype references
Mice homozygous for a knock-out allele are viable and fertile, exhibit no physical defects, and develop normally with no detectable alterations in iron metabolism.
Gene Ontology
(GO)
Classifications
less
  • All GO Annotations
    22
  • GO References
    6
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
RNA binding
signaling receptor activity
signaling receptor binding
transcription
transferase
transporter
Biological Process

carbohydrate derivative metabolism
cell differentiation
cell population proliferation
cellular component organization
DNA-templated transcription
establishment of localization
homeostatic process
immune system process
lipid metabolic process
programmed cell death
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
membraneless organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
protein-containing complex
synapse
vacuole
Click cells to view annotations.
Expression
less
Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
    655
  • Tissues
    24
  • cDNA Data
    37
  • Literature Summary
    4
Sequences &
Gene Models
less
Representative SequencesLengthStrain/SpeciesFlank
genomic ENSMUSG00000022780 Ensembl Gene Model | MGI Sequence Detail 20211 C57BL/6J ±  kb
transcript ENSMUST00000023464 Ensembl | MGI Sequence Detail 4133 Not Applicable  
polypeptide ENSMUSP00000023464 Ensembl | MGI Sequence Detail 738 Not Applicable  
For the selected sequence
Protein
Information
less
Molecular
Reagents
less
  • All nucleic 38
    cDNA 37
    Primer pair 1

    Microarray probesets 3
References
more
  • Summaries
    All 41
    Developmental Gene Expression 4
    Gene Ontology 6
    Phenotypes 15
  • Earliest
    J:58252 Nakamasu K, et al., Membrane-bound transferrin-like protein (MTf): structure, evolution and selective expression during chondrogenic differentiation of mouse embryonic cells. Biochim Biophys Acta. 1999 Oct 28;1447(2-3):258-64
  • Latest
    J:351035 Tan Z, et al., Progenitor-like cells contributing to cellular heterogeneity in the nucleus pulposus are lost in intervertebral disc degeneration. Cell Rep. 2024 Jun 25;43(6):114342
Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
Citing These Resources
Funding Information
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Send questions and comments to User Support. 		last database update
09/08/2026
MGI 6.24 		The Jackson Laboratory