Ndrg3 MGI Mouse Gene Detail - MGI:1352499 - N-myc downstream regulated gene 3

Symbol

Ndrg3
Name

N-myc downstream regulated gene 3
Synonyms

4833415O14Rik, Ndr3

Feature Type

protein coding gene
IDs

MGI:1352499
NCBI Gene: 29812
Alliance

genome feature page
Transcription Start Sites

16 TSS

Sequence Map

Chr2:156769265-156833976 bp, - strand
From Ensembl annotation of GRCm39
View this region in JBrowse
Genome Browsers

Ensembl | UCSC | NCBI

Genetic Map

Chromosome 2, 77.89 cM
Mapping Data

3 experiments

SNPs within 2kb

1650 from dbSNP Build 142
Strain Annotations

19

For selected strains:

Strain	Gene Model ID	Feature Type	Coordinates
C57BL/6J	MGI_C57BL6J_1352499	protein coding gene	Chr2:156769262-156834052 (-)
129S1/SvImJ	ENSMUSG00200015280	protein coding gene	Chr2:153632727-153697635 (-)
A/J	ENSMUSG00195018372	protein coding gene	Chr2:153999218-154064255 (-)
AKR/J	ENSMUSG00220012371	protein coding gene	Chr2:153301279-153366396 (-)
BALB/cJ	ENSMUSG00180048680	protein coding gene	Chr2:153453993-153518706 (-)
C3H/HeJ	ENSMUSG00175045772	protein coding gene	Chr2:154204308-154269018 (-)
C57BL/6NJ	ENSMUSG00215025021	protein coding gene	Chr2:153618507-153683220 (-)
CAROLI/EiJ	MGP_CAROLIEiJ_G0024566	protein coding gene	Chr2:148876925-148941670 (-)
CAST/EiJ	ENSTCUG00005042917	protein coding gene	Chr2:152599929-152665121 (-)
CBA/J	ENSMUSG00210016064	protein coding gene	Chr2:154135448-154200149 (-)
DBA/2J	ENSMUSG00185047928	protein coding gene	Chr2:153843265-153908384 (-)
FVB/NJ	ENSMUSG00205023189	protein coding gene	Chr2:152894265-152951078 (-)
JF1/MsJ	ENSUMUG00000017464	protein coding gene	Chr2:153499535-153564654 (-)
LP/J	ENSMUSG00230042455	protein coding gene	Chr2:155430472-155495361 (-)
NOD/ShiLtJ	ENSMUSG00190036637	protein coding gene	Chr2:153523871-153588577 (-)
NZO/HlLtJ	ENSMUSG00225051848	protein coding gene	Chr2:163450759-163515480 (-)
PWK/PhJ	ENSLUMG00010039805	protein coding gene	Chr2:153433045-153499693 (-)
SPRET/EiJ	ENSMSPG00010028531	protein coding gene	Chr2:156217514-156282521 (-)
WSB/EiJ	ENSIUOG00005043499	protein coding gene	Chr2:153214282-153278946 (-)

Human Ortholog

NDRG3, NDRG family member 3

Vertebrate Orthologs

5

Vertebrate Orthology Source

Alliance of Genome Resources

Human Ortholog

NDRG3, NDRG family member 3
Links

HGNC:14462

NCBI Gene ID: 57446

UniProt: Q9UGV2
Chr Location

20q11.23; chr20:36651766-36746128 (-) GRCh38

MGI Vertebrate Homology

Ndrg3 stringent orthology
1 human;1 mouse;2 rat;2 zebrafish
HCOP

vertebrate homology predictions: NDRG3
Gene Tree

Ndrg3

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Phenotype Summary

15 phenotypes from 3 alleles in 3 genetic backgrounds
19 phenotype references

Phenotype Overview

Blue squares indicate phenotypes directly attributed to mutations/alleles of this gene.

adipose tissue	behavior/neurological	cardiovascular system	cellular	craniofacial	digestive/alimentary system	embryo	endocrine/exocrine glands	growth/size/body	hearing/vestibular/ear	hematopoietic system	homeostasis/metabolism	integument	immune system	limbs/digits/tail	liver/biliary system	mortality/aging	muscle	nervous system	pigmentation	renal/urinary system	reproductive system	respiratory system	skeleton	taste/olfaction	neoplasm	vision/eye

Click cells to view annotations.

All Mutations and Alleles

24
Endonuclease-mediated

4
Gene trapped

17
Targeted

3
Incidental Mutations

Mutagenetix , APF
Find Mice (IMSR)

44 strains or lines available
Comparison Matrix

Gene Expression + Phenotype

Homozygous mutation of this gene results in lethality before weaning. Mice heterozygous for another null allele exhibit reduced male fertility due to impaired double strand break repair in spermatocytes.

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All GO Annotations

6
GO References

5

Molecular Function

No experimental evidence to support Molecular Function annotation, following literature review. See J:73796.

Biological Process

carbohydrate derivative metabolism	cell differentiation	cell population proliferation	cellular component organization	DNA-templated transcription	establishment of localization	homeostatic process	immune system process	lipid metabolic process	programmed cell death	protein metabolic process	response to stimulus	signaling	system development

Cellular Component

cell projection	cytoplasmic vesicle	cytoskeleton	cytosol	endoplasmic reticulum	endosome	extracellular region	Golgi apparatus	mitochondrion	membraneless organelle	nucleus	organelle envelope	organelle lumen	plasma membrane	protein-containing complex	synapse	vacuole

Click cells to view annotations.

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Expression Overview

GXD's primary emphasis is on endogenous gene expression during development. Click on grid cells to view annotations.

Blue cells = expressed in wild-type.
Gray triangles = other expression annotations only
(e.g. absence of expression or data from mutants).

early conceptus	embryo ectoderm	embryo endoderm	embryo mesoderm	embryo mesenchyme	extraembryonic component	alimentary system	auditory system	branchial arches	cardiovascular system	connective tissue	endocrine system	exocrine system	hemolymphoid system	integumental system	limbs	liver and biliary system	musculoskeletal system	nervous system	olfactory system	reproductive system	respiratory system	urinary system	visual system

Click cells to view annotations.

Assay Results

727
Tissues

79
cDNA Data

14
Literature Summary

6

Images

Tissue x Stage Matrix

Comparison Matrix

Gene Expression + Phenotype

Other Mouse Links

Allen Institute

GENSAT

GEO

Expression Atlas
Other Vertebrate Links

Xenbase ndrg3

ZFIN ndrg3a, ndrg3b

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All Sequences

95
RefSeq

30
UniProt

5
CCDS

CCDS16971.1, CCDS50780.1

Ensembl

ENSMUSG00000027634 (Evidence)
NCBI Gene

29812

			Length	Strain/Species	Flank
genomic	ENSMUSG00000027634	Ensembl Gene Model \| MGI Sequence Detail	64712	C57BL/6J	± kb
transcript	ENSMUST00000069600	Ensembl \| MGI Sequence Detail	2612	Not Applicable
polypeptide	ENSMUSP00000070052	Ensembl \| MGI Sequence Detail	388	Not Applicable

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UniProt

5 Sequences
Protein Ontology

PR:000011061 protein NDRG3

(term hierarchy)
InterPro Domains

IPR029058 Alpha/Beta hydrolase fold

IPR004142 NDRG
GlyGen

Q9QYF9 3 sites, 2 N-linked glycans (2 sites), 1 O-linked glycan (1 site)

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All nucleic 16

cDNA 15

Primer pair 1

Microarray probesets 6

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MGI:2139046, MGI:2442824

Summaries

All 55

Developmental Gene Expression 6

Gene Ontology 5

Phenotypes 19
Earliest

J:58924 Okuda T, et al., Identification of new genes ndr2 and ndr3 which are related to Ndr1/RTP/Drg1 but show distinct tissue specificity and response to N-myc. Biochem Biophys Res Commun. 1999 Dec 9;266(1):208-15
Latest

J:387647 Stack BJ, et al., NDRG3 is essential for sustaining antigen-driven T cell responses by protecting against restimulation-induced cell death. J Immunol. 2026 May 14;215(5)

TSS for Ndrg3:

(View these features in JBrowse)

Transcription Start Site	Location	Distance from Gene 5'-end
Tssr27086	Chr2:156833941-156834039 (-)	-14 bp
Tssr27085	Chr2:156833907-156833925 (-)	60 bp
Tssr27084	Chr2:156833758-156833767 (-)	213 bp
Tssr27083	Chr2:156833726-156833755 (-)	235 bp
Tssr27082	Chr2:156812473-156812493 (-)	21,493 bp
Tssr27081	Chr2:156812422-156812440 (-)	21,545 bp
Tssr27080	Chr2:156812404-156812414 (-)	21,567 bp
Tssr27079	Chr2:156812325-156812338 (-)	21,644 bp
Tssr27078	Chr2:156812200-156812213 (-)	21,769 bp
Tssr27077	Chr2:156795307-156795324 (-)	38,660 bp
Tssr27076	Chr2:156795283-156795298 (-)	38,685 bp
Tssr27075	Chr2:156795274-156795281 (-)	38,698 bp
Tssr27074	Chr2:156785343-156785346 (-)	48,631 bp
Tssr27073	Chr2:156770605-156770622 (-)	63,362 bp
Tssr27072	Chr2:156770523-156770539 (-)	63,445 bp
Tssr27071	Chr2:156769967-156770004 (-)	63,990 bp

Contributing Projects: Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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