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Pkd2l1 Gene Detail
Summary
  • Symbol
    Pkd2l1
  • Name
    polycystic kidney disease 2-like 1
  • Synonyms
    PCL, PKD2L, Pkdl, polycystin-L, TRPP3
Location &
Maps
more
  • Sequence Map
    Chr19:44136076-44180881 bp, - strand
    From Ensembl annotation of GRCm39
  • View this region in JBrowse
  • Genome Browsers
    Ensembl | UCSC | NCBI
  • Genetic Map
    Chromosome 19, 36.91 cM
  • Mapping Data
    2 experiments
Strain
Comparison
more
  • SNPs within 2kb
    1152 from dbSNP Build 142
  • Strain Annotations
    19
  • RFLP
    1
For selected strains:
Strain Gene Model ID Feature Type Coordinates Select Strains
C57BL/6J MGI_C57BL6J_1352448
 protein coding gene Chr19:44136076-44235355 (-)
129S1/SvImJ ENSMUSG00200020826
 protein coding gene Chr19:40860062-40899008 (-)
A/J ENSMUSG00195014262
 protein coding gene Chr19:40981144-41020066 (-)
AKR/J ENSMUSG00220018468
 protein coding gene Chr19:40779566-40818481 (-)
BALB/cJ ENSMUSG00180020346
 protein coding gene Chr19:41233535-41272456 (-)
C3H/HeJ ENSMUSG00175006348
 protein coding gene Chr19:40768614-40807523 (-)
C57BL/6NJ ENSMUSG00215004688
 protein coding gene Chr19:40825933-40871107 (-)
CAROLI/EiJ MGP_CAROLIEiJ_G0022994
 protein coding gene Chr19:40812969-40863793 (-)
CAST/EiJ ENSTCUG00005016707
 protein coding gene Chr19:40419534-40458570 (-)
CBA/J ENSMUSG00210018666
 protein coding gene Chr19:40848290-40887198 (-)
DBA/2J ENSMUSG00185007922
 protein coding gene Chr19:41357206-41396131 (-)
FVB/NJ ENSMUSG00205016885
 protein coding gene Chr19:40283569-40322505 (-)
JF1/MsJ ENSUMUG00000034014
 protein coding gene Chr19:41511748-41550609 (-)
LP/J ENSMUSG00230018811
 protein coding gene Chr19:42130001-42168939 (-)
NOD/ShiLtJ ENSMUSG00190004855
 protein coding gene Chr19:40707042-40745990 (-)
NZO/HlLtJ ENSMUSG00225041541
 protein coding gene Chr19:45716263-45755170 (-)
PWK/PhJ ENSLUMG00010000983
 protein coding gene Chr19:40677882-40716663 (-)
SPRET/EiJ ENSMSPG00010007463
 protein coding gene Chr19:40425858-40464954 (-)
WSB/EiJ ENSIUOG00005005909
 protein coding gene Chr19:40225582-40264501 (-)



Homology
more
  • Human Ortholog
    PKD2L1, polycystin 2 like 1, transient receptor potential cation channel
  • Vertebrate Orthologs
    3
Vertebrate Orthology Source
Alliance of Genome Resources
  • Human Ortholog
    PKD2L1, polycystin 2 like 1, transient receptor potential cation channel
  • Synonyms
    PCL, PKD2L, PKDL, TRPP3
  • Links
    NCBI Gene ID: 9033
    UniProt: Q9P0L9

  • Chr Location
    10q24.31; chr10:100288149-100330264 (-)  GRCh38
Mutations,
Alleles, and
Phenotypes
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  • Phenotype Summary
    2 phenotypes from 1 allele in 1 genetic background
    2 phenotypes from multigenic genotypes
    31 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
integument
immune system
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
neoplasm
vision/eye

Click cells to view annotations.
Mice homozygous for a knock-out allele exhibit decreased chorda tympani nerve response to sour tastants.
Gene Ontology
(GO)
Classifications
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  • All GO Annotations
    97
  • GO References
    21
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
RNA binding
signaling receptor activity
signaling receptor binding
transcription
transferase
transporter
Biological Process

carbohydrate derivative metabolism
cell differentiation
cell population proliferation
cellular component organization
DNA-templated transcription
establishment of localization
homeostatic process
immune system process
lipid metabolic process
programmed cell death
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
membraneless organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
protein-containing complex
synapse
vacuole
Click cells to view annotations.
Expression
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Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
    618
  • Tissues
    10
  • cDNA Data
    10
  • Literature Summary
    11
Sequences &
Gene Models
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Representative SequencesLengthStrain/SpeciesFlank
genomic ENSMUSG00000037578 Ensembl Gene Model | MGI Sequence Detail 44806 C57BL/6J ±  kb
transcript ENSMUST00000042026 Ensembl | MGI Sequence Detail 3321 Not Applicable  
polypeptide ENSMUSP00000045675 Ensembl | MGI Sequence Detail 760 Not Applicable  
For the selected sequence
Protein
Information
less
Molecular
Reagents
less
  • All nucleic 13
    cDNA 11
    Primer pair 2

    Microarray probesets 2
Other
Accession IDs
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MGI:1330816, MGI:3040679
References
more
  • Summaries
    All 95
    Developmental Gene Expression 11
    Gene Ontology 21
    Phenotypes 31
  • Earliest
    J:20807 Keller SA, et al., Kidney and retinal defects (Krd), a transgene-induced mutation with a deletion of mouse chromosome 19 that includes the Pax2 locus. Genomics. 1994 Sep 15;23(2):309-20
  • Latest
    J:378186 Leblond L, et al., Spinal cord morphology and PKD2L1(+) cells distribution: effects of age, sex, and spinal segment in mice. Front Neuroanat. 2025;19:1652848
Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
Citing These Resources
Funding Information
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Send questions and comments to User Support. 		last database update
09/08/2026
MGI 6.24 		The Jackson Laboratory