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Tjp3 Gene Detail
Summary
  • Symbol
    Tjp3
  • Name
    tight junction protein 3
  • Synonyms
    ZO-3
  • Feature Type
    protein coding gene
  • IDs
    MGI:1351650
    NCBI Gene: 27375
  • Alliance
    genome feature page
  • Transcription Start Sites
    5 TSS
Location &
Maps
more
  • Sequence Map
    Chr10:81109041-81127415 bp, - strand
    From Ensembl annotation of GRCm39
  • View this region in JBrowse
  • Genome Browsers
    Ensembl | UCSC | NCBI
  • Genetic Map
    Chromosome 10, 39.72 cM, cytoband C1
  • Mapping Data
    2 experiments
Strain
Comparison
more
  • SNPs within 2kb
    372 from dbSNP Build 142
  • Strain Annotations
    19
For selected strains:
Strain Gene Model ID Feature Type Coordinates Select Strains
C57BL/6J MGI_C57BL6J_1351650
 protein coding gene Chr10:81109022-81127415 (-)
129S1/SvImJ ENSMUSG00200044454
 protein coding gene Chr10:77736184-77754558 (-)
A/J ENSMUSG00195049210
 protein coding gene Chr10:78131454-78149830 (-)
AKR/J ENSMUSG00220046884
 protein coding gene Chr10:77729143-77747517 (-)
BALB/cJ ENSMUSG00180052259
 protein coding gene Chr10:78141907-78160281 (-)
C3H/HeJ ENSMUSG00175049844
 protein coding gene Chr10:78012658-78031033 (-)
C57BL/6NJ ENSMUSG00215052330
 protein coding gene Chr10:77754519-77772895 (-)
CAROLI/EiJ MGP_CAROLIEiJ_G0015631
 protein coding gene Chr10:75273894-75291351 (-)
CAST/EiJ ENSTCUG00005051435
 protein coding gene Chr10:77636197-77654611 (-)
CBA/J ENSMUSG00210049117
 protein coding gene Chr10:77868686-77887059 (-)
DBA/2J ENSMUSG00185046578
 protein coding gene Chr10:78211119-78229493 (-)
FVB/NJ ENSMUSG00205030366
 protein coding gene Chr10:77923934-77942309 (-)
JF1/MsJ ENSUMUG00000020895
 protein coding gene Chr10:79438495-79456898 (-)
LP/J ENSMUSG00230050673
 protein coding gene Chr10:79980703-79999078 (-)
NOD/ShiLtJ ENSMUSG00190043461
 protein coding gene Chr10:78124818-78143192 (-)
NZO/HlLtJ ENSMUSG00225052600
 protein coding gene Chr10:84267272-84285646 (-)
PWK/PhJ ENSLUMG00010044780
 protein coding gene Chr10:77802182-77820574 (-)
SPRET/EiJ ENSMSPG00010031696
 protein coding gene Chr10:79412363-79430363 (-)
WSB/EiJ ENSIUOG00005050166
 protein coding gene Chr10:77864877-77883285 (-)



Homology
more
  • Human Ortholog
    TJP3, tight junction protein 3
  • Vertebrate Orthologs
    3
Vertebrate Orthology Source
Alliance of Genome Resources
  • Human Ortholog
    TJP3, tight junction protein 3
  • Synonyms
    ZO-3, ZO3
  • Links
    NCBI Gene ID: 27134
    UniProt: O95049

  • Chr Location
    19p13.3; chr19:3708356-3750813 (+)  GRCh38
Mutations,
Alleles, and
Phenotypes
less
  • Phenotype Summary
    1 phenotype from 2 alleles in 2 genetic backgrounds
    11 phenotype references
Homozygous mutation of this gene results in viable and fertile mice with no abnormalities.
Gene Ontology
(GO)
Classifications
less
  • All GO Annotations
    36
  • GO References
    12
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
RNA binding
signaling receptor activity
signaling receptor binding
transcription
transferase
transporter
Biological Process

carbohydrate derivative metabolism
cell differentiation
cell population proliferation
cellular component organization
DNA-templated transcription
establishment of localization
homeostatic process
immune system process
lipid metabolic process
programmed cell death
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
membraneless organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
protein-containing complex
synapse
vacuole
Click cells to view annotations.
Expression
less
Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
    651
  • Tissues
    43
  • cDNA Data
    52
  • Literature Summary
    7
Sequences &
Gene Models
less
Representative SequencesLengthStrain/SpeciesFlank
genomic ENSMUSG00000034917 Ensembl Gene Model | MGI Sequence Detail 18375 C57BL/6J ±  kb
transcript ENSMUST00000045744 Ensembl | MGI Sequence Detail 3024 Not Applicable  
polypeptide ENSMUSP00000036438 Ensembl | MGI Sequence Detail 904 Not Applicable  
For the selected sequence
Protein
Information
less
Molecular
Reagents
less
  • All nucleic 52
    cDNA 52
    Antibodies 2

    Microarray probesets 5
References
more
  • Summaries
    All 49
    Developmental Gene Expression 7
    Gene Ontology 12
    Phenotypes 11
  • Earliest
    J:137335 Roderick TH, Chromosomal inversions in studies of mammalian mutagenesis. Genetics. 1979 May;92(1 Pt 1 Suppl):s121-6
  • Latest
    J:292950 Hinze C, et al., GRHL2 Is Required for Collecting Duct Epithelial Barrier Function and Renal Osmoregulation. J Am Soc Nephrol. 2018 Mar;29(3):857-868
Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
Citing These Resources
Funding Information
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Send questions and comments to User Support. 		last database update
09/08/2026
MGI 6.24 		The Jackson Laboratory