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Txnl4a Gene Detail
Summary
  • Symbol
    Txnl4a
  • Name
    thioredoxin-like 4A
  • Synonyms
    D18Wsu98e, ENSMUSG00000057130, Txnl4, U5-15kDa
  • Feature Type
    protein coding gene
  • IDs
    MGI:1351613
    NCBI Gene: 27366
  • Alliance
Location &
Maps
more
  • Sequence Map
    Chr18:80250041-80269066 bp, + strand
    From NCBI annotation of GRCm39
  • View this region in JBrowse
  • Genome Browsers
  • Genetic Map
    Chromosome 18, 53.34 cM
  • Mapping Data
    5 experiments
Strain
Comparison
more
  • SNPs within 2kb
    353 from dbSNP Build 142
  • Strain Annotations
    18
For selected strains:
Strain Gene Model ID Feature Type Coordinates Select Strains
C57BL/6J MGI_C57BL6J_1351613
protein coding gene Chr18:80250010-80269070 (+)
129S1/SvImJ MGP_129S1SvImJ_G0024592
protein coding gene Chr18:81114019-81132307 (+)
A/J MGP_AJ_G0024559
protein coding gene Chr18:77559186-77576079 (+)
AKR/J MGP_AKRJ_G0024530
protein coding gene Chr18:79885823-79905277 (+)
BALB/cJ MGP_BALBcJ_G0024557
protein coding gene Chr18:77745468-77763433 (+)
C3H/HeJ MGP_C3HHeJ_G0024326
protein coding gene Chr18:79968658-79985809 (+)
C57BL/6NJ MGP_C57BL6NJ_G0025004
protein coding gene Chr18:83196613-83213270 (+)
CAROLI/EiJ MGP_CAROLIEiJ_G0022435
protein coding gene Chr18:76415907-76432161 (+)
CAST/EiJ MGP_CASTEiJ_G0023799
protein coding gene Chr18:80301649-80318144 (+)
CBA/J MGP_CBAJ_G0024296
protein coding gene Chr18:86226906-86246138 (+)
DBA/2J MGP_DBA2J_G0024426
protein coding gene Chr18:77113040-77129494 (+)
FVB/NJ MGP_FVBNJ_G0024392
protein coding gene Chr18:76432453-76449365 (+)
LP/J MGP_LPJ_G0024510
protein coding gene Chr18:80984148-81000626 (+)
NOD/ShiLtJ MGP_NODShiLtJ_G0024422
protein coding gene Chr18:87465409-87494353 (+)
NZO/HlLtJ MGP_NZOHlLtJ_G0025053
protein coding gene Chr18:80026501-80043626 (+)
PWK/PhJ MGP_PWKPhJ_G0023544
protein coding gene Chr18:77508435-77526962 (+)
SPRET/EiJ MGP_SPRETEiJ_G0023350
protein coding gene Chr18:80205040-80222624 (+)
WSB/EiJ MGP_WSBEiJ_G0023861
protein coding gene Chr18:79978836-79996712 (+)



Homology
more
  • Human Ortholog
    TXNL4A, thioredoxin like 4A
  • Vertebrate Orthologs
    3
Vertebrate Orthology Source
Alliance of Genome Resources
  • Human Ortholog
    TXNL4A, thioredoxin like 4A
  • Synonyms
    BMKS, DIB1, DIM1, SNRNP15, TXNL4, U5-15kD
  • Links
    NCBI Gene ID: 10907
    neXtProt AC: NX_P83876
    UniProt: P83876

  • Chr Location
    18q23; chr18:79970813-80033949 (-)  GRCh38

Human Diseases
more
  • Diseases
    1 with human TXNL4A associations

Human Disease Mouse Models
      
IDs
Click on a disease name to see all genes associated with that disease.

Mutations,
Alleles, and
Phenotypes
less
  • Phenotype Summary
    1 phenotype from 1 allele in 1 genetic background
    9 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
integument
immune system
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
neoplasm
vision/eye

Click cells to view annotations.
  • All Mutations and Alleles
    20
  • Endonuclease-mediated
    1
  • Gene trapped
    18
  • Transposon induced
    1
  • Genomic Mutations
    1 involving Txnl4a
  • Incidental Mutations
    APF
  • Find Mice (IMSR)
Gene Ontology
(GO)
Classifications
less
  • All GO Annotations
  • GO References
Molecular Function

No experimental evidence to support Molecular Function annotation, following literature review. See J:73796.
Biological Process

carbohydrate derivative metabolism
cell differentiation
cell population proliferation
cellular component organization
DNA-templated transcription
establishment of localization
homeostatic process
immune system process
lipid metabolic process
programmed cell death
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
non-membrane-bounded organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
protein-containing complex
synapse
vacuole
Click cells to view annotations.
Expression
less
Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
  • Tissues
  • cDNA Data
  • Literature Summary
Sequences &
Gene Models
less
Representative SequencesLengthStrain/SpeciesFlank
genomic 27366 NCBI Gene Model | MGI Sequence Detail 19026 C57BL/6J ±  kb
transcript NR_168913 RefSeq | MGI Sequence Detail 4579 ZRU/MplStud  
polypeptide P83877 UniProt | EBI | MGI Sequence Detail 142 Not Applicable  
For the selected sequence
Protein
Information
less
Molecular
Reagents
less
  • All nucleic 17
    cDNA 16
    Primer pair 1

    Microarray probesets 5
Other
Accession IDs
less
MGD-MRK-33954, MGI:106262, MGI:3642561
References
more
  • Summaries
    All 36
    Developmental Gene Expression 2
    Gene Ontology 4
    Phenotypes 9
  • Earliest
    J:50869 Ko MSH, et al., Genome-wide mapping of unselected transcripts from extraembryonic tissue of 7.5-day mouse embryos reveals enrichment in the t-complex and under-representation on the X chromosome. Hum Mol Genet. 1998 Nov;7(12):1967-78
  • Latest
    J:198500 Nakahara M, et al., Gene-trap mutagenesis using Mol/MSM-1 embryonic stem cells from MSM/Ms mice. Mamm Genome. 2013 Jun;24(5-6):228-39

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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Funding Information
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last database update
03/19/2024
MGI 6.23
The Jackson Laboratory