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Grm4 Gene Detail
Summary
  • Symbol
    Grm4
  • Name
    glutamate receptor, metabotropic 4
  • Synonyms
    Gprc1d, mGluR4
  • Feature Type
    protein coding gene
  • IDs
    MGI:1351341
    NCBI Gene: 268934
  • Alliance
    genome feature page
  • Transcription Start Sites
    21 TSS
Location &
Maps
more
  • Sequence Map
    Chr17:27641361-27732800 bp, - strand
    From NCBI annotation of GRCm39
  • View this region in JBrowse
  • Genome Browsers
    Ensembl | UCSC | NCBI
  • Genetic Map
    Chromosome 17, 14.05 cM
  • Mapping Data
    1 experiment
Strain
Comparison
more
  • SNPs within 2kb
    664 from dbSNP Build 142
  • Strain Annotations
    19
For selected strains:
Strain Gene Model ID Feature Type Coordinates Select Strains
C57BL/6J MGI_C57BL6J_1351341
 protein coding gene Chr17:27641361-27740377 (-)
129S1/SvImJ ENSMUSG00200048939
 protein coding gene Chr17:23299428-23398709 (-)
A/J ENSMUSG00195054196
 protein coding gene Chr17:24118267-24216948 (-)
AKR/J ENSMUSG00220050295
 protein coding gene Chr17:23165771-23264568 (-)
BALB/cJ ENSMUSG00180043516
 protein coding gene Chr17:23596253-23695533 (-)
C3H/HeJ ENSMUSG00175050607
 protein coding gene Chr17:23154386-23253076 (-)
C57BL/6NJ ENSMUSG00215049706
 protein coding gene Chr17:23151943-23250994 (-)
CAROLI/EiJ MGP_CAROLIEiJ_G0021299
 protein coding gene Chr17:23271721-23360434 (-)
CAST/EiJ ENSTCUG00005046336
 protein coding gene Chr17:23877164-23976578 (-)
CBA/J ENSMUSG00210042839
 protein coding gene Chr17:22993164-23091836 (-)
DBA/2J ENSMUSG00185047069
 protein coding gene Chr17:25206447-25305138 (-)
FVB/NJ ENSMUSG00205051203
 protein coding gene Chr17:23469145-23567931 (-)
JF1/MsJ ENSUMUG00000056679
 protein coding gene Chr17:24660087-24759548 (-)
LP/J ENSMUSG00230055034
 protein coding gene Chr17:26725294-26824568 (-)
NOD/ShiLtJ ENSMUSG00190044840
 protein coding gene Chr17:23099438-23198478 (-)
NZO/HlLtJ ENSMUSG00225054091
 protein coding gene Chr17:28693396-28792416 (-)
PWK/PhJ ENSLUMG00010053231
 protein coding gene Chr17:22581172-22680531 (-)
SPRET/EiJ ENSMSPG00010039194
 protein coding gene Chr17:23883799-23982578 (-)
WSB/EiJ ENSIUOG00005047187
 protein coding gene Chr17:23857805-23956880 (-)



Homology
more
  • Human Ortholog
    GRM4, glutamate metabotropic receptor 4
  • Vertebrate Orthologs
    3
Vertebrate Orthology Source
Alliance of Genome Resources
  • Human Ortholog
    GRM4, glutamate metabotropic receptor 4
  • Synonyms
    GPRC1D, mGlu4, MGLUR4
  • Links
    NCBI Gene ID: 2914
    UniProt: Q14833

  • Chr Location
    6p21.31; chr6:34018643-34155622 (-)  GRCh38
Mutations,
Alleles, and
Phenotypes
less
  • Phenotype Summary
    4 phenotypes from 2 alleles in 2 genetic backgrounds
    34 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
integument
immune system
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
neoplasm
vision/eye

Click cells to view annotations.
Homozygous mutation of theis gene results in impaired motor learning, and reduced paired-pulse facilitation and post-tetanic potential.
Gene Ontology
(GO)
Classifications
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  • All GO Annotations
    41
  • GO References
    11
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
RNA binding
signaling receptor activity
signaling receptor binding
transcription
transferase
transporter
Biological Process

carbohydrate derivative metabolism
cell differentiation
cell population proliferation
cellular component organization
DNA-templated transcription
establishment of localization
homeostatic process
immune system process
lipid metabolic process
programmed cell death
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
membraneless organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
protein-containing complex
synapse
vacuole
Click cells to view annotations.
Expression
less
Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
    775
  • Tissues
    49
  • cDNA Data
    11
  • Literature Summary
    8
Sequences &
Gene Models
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Representative SequencesLengthStrain/SpeciesFlank
genomic 268934 NCBI Gene Model | MGI Sequence Detail 91440 C57BL/6J ±  kb
transcript NM_001291045 RefSeq | MGI Sequence Detail 4593 C57BL/6  
polypeptide Q68EF4 UniProt | EBI | MGI Sequence Detail 912 Not Applicable  
For the selected sequence
Protein
Information
less
  • UniProt
    6 Sequences
  • Protein Ontology
    PR:000008266 metabotropic glutamate receptor 4
    (term hierarchy)
  • InterPro Domains
    IPR000337 GPCR, family 3
    IPR017979 GPCR, family 3, conserved site
    IPR017978 GPCR family 3, C-terminal
    IPR000162 GPCR, family 3, metabotropic glutamate receptor
    IPR001786 GPCR, family 3, metabotropic glutamate receptor 4
    IPR011500 GPCR, family 3, nine cysteines domain
    IPR038550 GPCR, family 3, nine cysteines domain superfamily
    IPR050726 Metabotropic Glutamate Receptor
    IPR028082 Periplasmic binding protein-like I
    IPR001828 Receptor, ligand binding region
  • GlyGen
    Q68EF4 5 sites, 5 N-linked glycans (3 sites), 1 O-linked glycan (1 site)
Molecular
Reagents
less
  • All nucleic 12
    cDNA 11
    Primer pair 1

    Microarray probesets 2
Other
Accession IDs
less
MGD-MRK-10267, MGI:95828
References
more
  • Summaries
    All 80
    Developmental Gene Expression 8
    Gene Ontology 11
    Phenotypes 34
  • Earliest
    J:35793 Pekhletski R, et al., Impaired cerebellar synaptic plasticity and motor performance in mice lacking the mGluR4 subtype of metabotropic glutamate receptor. J Neurosci. 1996 Oct 15;16(20):6364-73
  • Latest
    J:378433 Perez-Canamas A, et al., mGluR4-NPDC1 complex mediates alpha-synuclein fibril-induced neurodegeneration. Nat Commun. 2025 Dec 25;17(1):994
Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
Citing These Resources
Funding Information
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Send questions and comments to User Support. 		last database update
09/08/2026
MGI 6.24 		The Jackson Laboratory