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Grm3 Gene Detail
Summary
  • Symbol
    Grm3
  • Name
    glutamate receptor, metabotropic 3
  • Synonyms
    0710001G23Rik, Gprc1c, mGlu3, mGluR3
  • Feature Type
    protein coding gene
  • IDs
    MGI:1351340
    NCBI Gene: 108069
  • Alliance
    genome feature page
  • Transcription Start Sites
    9 TSS
Location &
Maps
more
  • Sequence Map
    Chr5:9535541-9775170 bp, - strand
    From Ensembl annotation of GRCm39
  • View this region in JBrowse
  • Genome Browsers
    Ensembl | UCSC | NCBI
  • Genetic Map
    Chromosome 5, 3.69 cM
  • Mapping Data
    1 experiment
Strain
Comparison
more
  • SNPs within 2kb
    6636 from dbSNP Build 142
  • Strain Annotations
    19
For selected strains:
Strain Gene Model ID Feature Type Coordinates Select Strains
C57BL/6J MGI_C57BL6J_1351340
 protein coding gene Chr5:9535235-9776087 (-)
129S1/SvImJ ENSMUSG00200002512
 protein coding gene Chr5:6263099-6515546 (-)
A/J ENSMUSG00195007635
 protein coding gene Chr5:6243519-6483154 (-)
AKR/J ENSMUSG00220001845
 protein coding gene Chr5:6046471-6295498 (-)
BALB/cJ ENSMUSG00180016735
 protein coding gene Chr5:5995641-6235282 (-)
C3H/HeJ ENSMUSG00175026170
 protein coding gene Chr5:6186570-6426202 (-)
C57BL/6NJ ENSMUSG00215022634
 protein coding gene Chr5:6452458-6692111 (-)
CAROLI/EiJ MGP_CAROLIEiJ_G0026966
 protein coding gene Chr5:6019956-6248905 (-)
CAST/EiJ ENSTCUG00005001509
 protein coding gene Chr5:6335744-6577875 (-)
CBA/J ENSMUSG00210002230
 protein coding gene Chr5:6536992-6776618 (-)
DBA/2J ENSMUSG00185028591
 protein coding gene Chr5:6539185-6778816 (-)
FVB/NJ ENSMUSG00205007963
 protein coding gene Chr5:6245832-6485489 (-)
JF1/MsJ ENSUMUG00000003090
 protein coding gene Chr5:6597320-6854296 (-)
LP/J ENSMUSG00230003092
 protein coding gene Chr5:10517661-10770074 (-)
NOD/ShiLtJ ENSMUSG00190012157
 protein coding gene Chr5:6052643-6292271 (-)
NZO/HlLtJ ENSMUSG00225008207
 protein coding gene Chr5:14247264-14486929 (-)
PWK/PhJ ENSLUMG00010019161
 protein coding gene Chr5:6476681-6725570 (-)
SPRET/EiJ ENSMSPG00010004747
 protein coding gene Chr5:6426566-6706776 (-)
WSB/EiJ ENSIUOG00005024991
 protein coding gene Chr5:6286298-6525118 (-)



Homology
more
  • Human Ortholog
    GRM3, glutamate metabotropic receptor 3
  • Vertebrate Orthologs
    3
Vertebrate Orthology Source
Alliance of Genome Resources
  • Human Ortholog
    GRM3, glutamate metabotropic receptor 3
  • Synonyms
    GLUR3, GPRC1C, mGlu3, MGLUR3
  • Links
    NCBI Gene ID: 2913
    UniProt: Q14832

  • Chr Location
    7q21.11-q21.12; chr7:86643909-86864884 (+)  GRCh38
Mutations,
Alleles, and
Phenotypes
less
  • Phenotype Summary
    13 phenotypes from 4 alleles in 4 genetic backgrounds
    32 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
integument
immune system
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
neoplasm
vision/eye

Click cells to view annotations.
Mice homozygous for a targeted mutation display normal morphology, clinical chemistry, hematology, and behavior. Mice homozygous for a knock-out allele exhibit altered neuroprotection.
Gene Ontology
(GO)
Classifications
less
  • All GO Annotations
    44
  • GO References
    16
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
RNA binding
signaling receptor activity
signaling receptor binding
transcription
transferase
transporter
Biological Process

carbohydrate derivative metabolism
cell differentiation
cell population proliferation
cellular component organization
DNA-templated transcription
establishment of localization
homeostatic process
immune system process
lipid metabolic process
programmed cell death
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
membraneless organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
protein-containing complex
synapse
vacuole
Click cells to view annotations.
Expression
less
Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
    976
  • Tissues
    224
  • cDNA Data
    9
  • Literature Summary
    16
  • Comparison Matrix
    Gene Expression + Phenotype
    • Sequences &
    Gene Models
    less
    Representative SequencesLengthStrain/SpeciesFlank
    genomic ENSMUSG00000003974 Ensembl Gene Model | MGI Sequence Detail 239630 C57BL/6J ±  kb
    transcript ENSMUST00000004076 Ensembl | MGI Sequence Detail 3049 Not Applicable  
    polypeptide ENSMUSP00000004076 Ensembl | MGI Sequence Detail 879 Not Applicable  
    For the selected sequence
    Protein
    Information
    less
    • UniProt
      2 Sequences
    • Protein Ontology
      PR:000008265 metabotropic glutamate receptor 3
      (term hierarchy)
    • InterPro Domains
      IPR000337 GPCR, family 3
      IPR017979 GPCR, family 3, conserved site
      IPR017978 GPCR family 3, C-terminal
      IPR000162 GPCR, family 3, metabotropic glutamate receptor
      IPR001234 GPCR, family 3, metabotropic glutamate receptor 3
      IPR011500 GPCR, family 3, nine cysteines domain
      IPR038550 GPCR, family 3, nine cysteines domain superfamily
      IPR050726 Metabotropic Glutamate Receptor
      IPR028082 Periplasmic binding protein-like I
      IPR001828 Receptor, ligand binding region
    • GlyGen
      Q9QYS2 5 sites, 14 N-linked glycans (2 sites), 1 O-linked glycan (1 site)
    Molecular
    Reagents
    less
    • All nucleic 14
      cDNA 10
      Primer pair 3
      Other 1
      Antibodies 1

      Microarray probesets 3
    Other
    Accession IDs
    less
    MGD-MRK-10266, MGI:1917596, MGI:95827
    References
    more
    • Summaries
      All 99
      Developmental Gene Expression 16
      Gene Ontology 16
      Phenotypes 32
    • Earliest
      J:21416 Chavis P, et al., The metabotropic glutamate receptor types 2/3 inhibit L-type calcium channels via a pertussis toxin-sensitive G-protein in cultured cerebellar granule cells. J Neurosci. 1994 Nov;14(11 Pt 2):7067-76
    • Latest
      J:383233 Olivera E, et al., A Decline in Metabotropic Glutamate mGlu3 Receptor Levels Is Associated With Amyloid Plaques in Alzheimer's Disease and Is Detectable in Serum During Mild Cognitive Impairment. J Neurochem. 2026 Apr;170(4):e70417
    Contributing Projects:
    Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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    Funding Information
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    09/08/2026
    MGI 6.24     		The Jackson Laboratory