Atp1a4 MGI Mouse Gene Detail - MGI:1351335 - ATPase, Na+/K+ transporting, alpha 4 polypeptide

Symbol

Atp1a4
Name

ATPase, Na+/K+ transporting, alpha 4 polypeptide

Feature Type

protein coding gene
IDs

MGI:1351335
NCBI Gene: 27222
Alliance

gene page
Transcription Start Sites

4 TSS

Sequence Map

Chr1:172051080-172085981 bp, - strand
From Ensembl annotation of GRCm39
View this region in JBrowse
Genome Browsers

Ensembl | UCSC | NCBI

Genetic Map

Chromosome 1, 79.54 cM
Mapping Data

5 experiments

SNPs within 2kb

398 from dbSNP Build 142
Strain Annotations

18

For selected strains:

Strain	Gene Model ID	Feature Type	Coordinates
C57BL/6J	MGI_C57BL6J_1351335	protein coding gene	Chr1:172051075-172085991 (-)
129S1/SvImJ	MGP_129S1SvImJ_G0016782	protein coding gene	Chr1:178081748-178120282 (-)
A/J	MGP_AJ_G0016761	protein coding gene	Chr1:170791961-170829037 (-)
AKR/J	MGP_AKRJ_G0016727	protein coding gene	Chr1:175954404-175991662 (-)
BALB/cJ	MGP_BALBcJ_G0016722	protein coding gene	Chr1:171338908-171374924 (-)
C3H/HeJ	MGP_C3HHeJ_G0016546	protein coding gene	Chr1:176527897-176564116 (-)
C57BL/6NJ	MGP_C57BL6NJ_G0017184	protein coding gene	Chr1:183993474-184028294 (-)
CAROLI/EiJ	MGP_CAROLIEiJ_G0014890	protein coding gene	Chr1:162496497-162531683 (-)
CAST/EiJ	MGP_CASTEiJ_G0016126	protein coding gene	Chr1:175889779-175930353 (-)
CBA/J	MGP_CBAJ_G0016520	protein coding gene	Chr1:190544349-190580114 (-)
DBA/2J	MGP_DBA2J_G0016627	protein coding gene	Chr1:169728954-169765140 (-)
FVB/NJ	MGP_FVBNJ_G0016624	protein coding gene	Chr1:167985084-168020882 (-)
LP/J	MGP_LPJ_G0016698	protein coding gene	Chr1:179175332-179212740 (-)
NOD/ShiLtJ	MGP_NODShiLtJ_G0016651	protein coding gene	Chr1:197791515-197828032 (-)
NZO/HlLtJ	MGP_NZOHlLtJ_G0017220	protein coding gene	Chr1:175824247-175859906 (-)
PWK/PhJ	MGP_PWKPhJ_G0015912	protein coding gene	Chr1:169104676-169141100 (-)
SPRET/EiJ	MGP_SPRETEiJ_G0015694	protein coding gene	Chr1:174774010-174809754 (-)
WSB/EiJ	MGP_WSBEiJ_G0016188	protein coding gene	Chr1:175979561-176016452 (-)

Human Ortholog

ATP1A4, ATPase Na+/K+ transporting subunit alpha 4

Vertebrate Orthologs

2

Vertebrate Orthology Source

Alliance of Genome Resources

Human Ortholog

ATP1A4, ATPase Na+/K+ transporting subunit alpha 4
Synonyms

ATP1A1, ATP1AL2
Links

HGNC:14073

NCBI Gene ID: 480

neXtProt AC: NX_Q13733

UniProt: Q13733
Chr Location

1q23.2; chr1:160151586-160186980 (+) GRCh38

MGI Vertebrate Homology

Atp1a4 stringent orthology
1 human;1 mouse;1 rat
HCOP

vertebrate homology predictions: ATP1A4
Gene Tree

Atp1a4

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Phenotype Summary

9 phenotypes from 3 alleles in 2 genetic backgrounds
14 phenotype references

Phenotype Overview

Blue squares indicate phenotypes directly attributed to mutations/alleles of this gene.

adipose tissue	behavior/neurological	cardiovascular system	cellular	craniofacial	digestive/alimentary system	embryo	endocrine/exocrine glands	growth/size/body	hearing/vestibular/ear	hematopoietic system	homeostasis/metabolism	integument	immune system	limbs/digits/tail	liver/biliary system	mortality/aging	muscle	nervous system	pigmentation	renal/urinary system	reproductive system	respiratory system	skeleton	taste/olfaction	neoplasm	vision/eye

Click cells to view annotations.

All Mutations and Alleles

10
Chemically induced (other)

2
Endonuclease-mediated

1
Gene trapped

2
Targeted

5
Genomic Mutations

2 involving Atp1a4
Incidental Mutations

Mutagenetix , APF
Find Mice (IMSR)

48 strains or lines available
Comparison Matrix

Gene Expression + Phenotype

Male mice homozygous for a knock-out allele exhibit infertility associated with asthenozoospermia and teratozoospermia.

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All GO Annotations

38
GO References

11

Molecular Function

carbohydrate derivative binding	cytoskeletal protein binding	DNA binding	enzyme regulator	hydrolase	ligase	lipid binding	oxidoreductase	RNA binding	signaling receptor activity	signaling receptor binding	transcription	transferase	transporter

Biological Process

carbohydrate derivative metabolism	cell differentiation	cell population proliferation	cellular component organization	DNA-templated transcription	establishment of localization	homeostatic process	immune system process	lipid metabolic process	programmed cell death	protein metabolic process	response to stimulus	signaling	system development

Cellular Component

cell projection	cytoplasmic vesicle	cytoskeleton	cytosol	endoplasmic reticulum	endosome	extracellular region	Golgi apparatus	mitochondrion	non-membrane-bounded organelle	nucleus	organelle envelope	organelle lumen	plasma membrane	protein-containing complex	synapse	vacuole

Click cells to view annotations.

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Expression Overview

GXD's primary emphasis is on endogenous gene expression during development. Click on grid cells to view annotations.

Blue cells = expressed in wild-type.
Gray triangles = other expression annotations only
(e.g. absence of expression or data from mutants).

early conceptus	embryo ectoderm	embryo endoderm	embryo mesoderm	embryo mesenchyme	extraembryonic component	alimentary system	auditory system	branchial arches	cardiovascular system	connective tissue	endocrine system	exocrine system	hemolymphoid system	integumental system	limbs	liver and biliary system	musculoskeletal system	nervous system	olfactory system	reproductive system	respiratory system	urinary system	visual system

Click cells to view annotations.

Assay Results

839
Tissues

118
cDNA Data

9
Literature Summary

5

Images

Tissue x Stage Matrix

Comparison Matrix

Gene Expression + Phenotype

Other Mouse Links

Allen Institute

GEO

Expression Atlas

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All Sequences

34
RefSeq

4
UniProt

1
CCDS

CCDS48446.1

Ensembl

ENSMUSG00000007107 (Evidence)
NCBI Gene

27222

			Length	Strain/Species	Flank
genomic	ENSMUSG00000007107	Ensembl Gene Model \| MGI Sequence Detail	34902	C57BL/6J	± kb
transcript	ENSMUST00000111243	Ensembl \| MGI Sequence Detail	3470	Not Applicable
polypeptide	ENSMUSP00000106874	Ensembl \| MGI Sequence Detail	1032	Not Applicable

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UniProt

1 Sequence
Protein Ontology

PR:000004438 sodium/potassium-transporting ATPase subunit alpha-4

(term hierarchy)
EC

7.2.2.13
InterPro Domains

IPR006068 Cation-transporting P-type ATPase, C-terminal

IPR004014 Cation-transporting P-type ATPase, N-terminal

IPR036412 HAD-like superfamily

IPR023214 HAD superfamily

IPR001757 P-type ATPase

IPR008250 P-type ATPase, A domain superfamily

IPR023299 P-type ATPase, cytoplasmic domain N

IPR044492 P-type ATPase, haloacid dehalogenase domain

IPR018303 P-type ATPase, phosphorylation site

IPR005775 P-type ATPase subfamily IIC, subunit alpha

IPR023298 P-type ATPase, transmembrane domain superfamily

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All nucleic 23

Genomic 11

cDNA 9

Primer pair 3

Microarray probesets 2

Summaries

All 46

Developmental Gene Expression 5

Gene Ontology 11

Phenotypes 14
Earliest

J:58404 Underhill DA, et al., The Na,K-ATPase alpha4 gene (Atp1a4) encodes a ouabain-resistant alpha subunit and is tightly linked to the alpha2 gene (Atp1a2) on mouse chromosome 1. Biochemistry. 1999 Nov 9;38(45):14746-51
Latest

J:330275 Numata S, et al., The sodium-glucose cotransporter isoform 1 (SGLT-1) is important for sperm energetics, motility, and fertility. Biol Reprod. 2022 Jun 13;106(6):1206-1217

TSS for Atp1a4:

(View these features in JBrowse)

Transcription Start Site	Location	Distance from Gene 5'-end
Tssr15197	Chr1:172086011-172086020 (-)	-35 bp
Tssr15196	Chr1:172085977-172086005 (-)	-10 bp
Tssr15195	Chr1:172062202-172062222 (-)	23,769 bp
Tssr15194	Chr1:172062190-172062199 (-)	23,786 bp

Contributing Projects: Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
Citing These Resources Funding Information Warranty Disclaimer, Privacy Notice, Licensing, & Copyright Send questions and comments to User Support.	last database update 04/16/2024 MGI 6.23