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Nit1 Gene Detail
Summary
  • Symbol
    Nit1
  • Name
    nitrilase 1
  • Synonyms
    ESTM30
  • Feature Type
    protein coding gene
  • IDs
    MGI:1350916
    NCBI Gene: 27045
  • Alliance
    genome feature page
  • Transcription Start Sites
    4 TSS
Location &
Maps
more
  • Sequence Map
    Chr1:171168145-171173209 bp, - strand
    From NCBI annotation of GRCm39
  • View this region in JBrowse
  • Genome Browsers
    Ensembl | UCSC | NCBI
  • Genetic Map
    Chromosome 1, 79.35 cM
  • Mapping Data
    3 experiments
Strain
Comparison
more
  • SNPs within 2kb
    160 from dbSNP Build 142
  • Strain Annotations
    18
For selected strains:
Strain Gene Model ID Feature Type Coordinates Select Strains
C57BL/6J MGI_C57BL6J_1350916
 protein coding gene Chr1:171165576-171173214 (-)
129S1/SvImJ ENSMUSG00200046547
 protein coding gene Chr1:168647914-168655932 (-)
A/J ENSMUSG00195048262
 protein coding gene Chr1:167999017-168007024 (-)
AKR/J ENSMUSG00220026614
 protein coding gene Chr1:167749518-167757528 (-)
BALB/cJ ENSMUSG00180044289
 protein coding gene Chr1:168288173-168296192 (-)
C3H/HeJ ENSMUSG00175041577
 protein coding gene Chr1:168299260-168307278 (-)
C57BL/6NJ ENSMUSG00215044193
 protein coding gene Chr1:168122393-168130406 (-)
CAROLI/EiJ MGP_CAROLIEiJ_G0014866
 protein coding gene Chr1:161601156-161608730 (-)
CAST/EiJ ENSTCUG00005043381
 protein coding gene Chr1:166633387-166641389 (-)
CBA/J ENSMUSG00210034658
 protein coding gene Chr1:168176200-168184224 (-)
DBA/2J ENSMUSG00185027548
 protein coding gene Chr1:172490149-172498176 (-)
FVB/NJ ENSMUSG00205035172
 protein coding gene Chr1:167185202-167193221 (-)
JF1/MsJ no annotation
LP/J ENSMUSG00230025567
 protein coding gene Chr1:172065032-172073051 (-)
NOD/ShiLtJ ENSMUSG00190032388
 protein coding gene Chr1:167971066-167979076 (-)
NZO/HlLtJ ENSMUSG00225004001
 protein coding gene Chr1:175682563-175690571 (-)
PWK/PhJ ENSLUMG00010029706
 protein coding gene Chr1:166965790-166973796 (-)
SPRET/EiJ ENSMSPG00010045733
 protein coding gene Chr1:170498970-170506970 (-)
WSB/EiJ ENSIUOG00005037470
 protein coding gene Chr1:167385458-167393467 (-)



Homology
more
  • Human Ortholog
    NIT1, nitrilase 1
  • Vertebrate Orthologs
    3
Vertebrate Orthology Source
Alliance of Genome Resources
  • Human Ortholog
    NIT1, nitrilase 1
  • Synonyms
    BSVD4
  • Links
    NCBI Gene ID: 4817
    UniProt: Q86X76

  • Chr Location
    1q23.3; chr1:161118082-161125445 (+)  GRCh38
Human Diseases
more
  • Diseases
    1 with human NIT1 associations

Human Disease Mouse Models
      
IDs
Click on a disease name to see all genes associated with that disease.

Mutations,
Alleles, and
Phenotypes
less
  • Phenotype Summary
    5 phenotypes from 2 alleles in 2 genetic backgrounds
    12 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
integument
immune system
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
neoplasm
vision/eye

Click cells to view annotations.
Mice that are either heterozygous or homozygous for a knock-out allele exhibit increased incidence of N-nitrosomethylbenzylamine (NMBA)-induced tumors in the forestomach (papillomas and dysplasias).
Gene Ontology
(GO)
Classifications
less
  • All GO Annotations
    15
  • GO References
    9
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
RNA binding
signaling receptor activity
signaling receptor binding
transcription
transferase
transporter
Biological Process

carbohydrate derivative metabolism
cell differentiation
cell population proliferation
cellular component organization
DNA-templated transcription
establishment of localization
homeostatic process
immune system process
lipid metabolic process
programmed cell death
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
membraneless organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
protein-containing complex
synapse
vacuole
Click cells to view annotations.
Expression
less
Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
    649
  • Tissues
    16
  • cDNA Data
    9
  • Literature Summary
    1
Sequences &
Gene Models
less
Representative SequencesLengthStrain/SpeciesFlank
genomic 27045 NCBI Gene Model | MGI Sequence Detail 5065 C57BL/6J ±  kb
transcript NM_001420681 RefSeq | MGI Sequence Detail 3375 ZRU/MplStud  
polypeptide Q8VDK1 UniProt | EBI | MGI Sequence Detail 323 Not Applicable  
For the selected sequence
Protein
Information
less
Molecular
Reagents
less
  • All nucleic 13
    Genomic 2
    cDNA 9
    Primer pair 2
    Antibodies 1

    Microarray probesets 4
Other
Accession IDs
less
MGI:1334466, MGI:2138182
References
more
  • Summaries
    All 44
    Developmental Gene Expression 1
    Gene Ontology 9
    Phenotypes 12
  • Earliest
    J:58686 Pekarsky Y, et al., Nitrilase and Fhit homologs are encoded as fusion proteins in Drosophila melanogaster and Caenorhabditis elegans. Proc Natl Acad Sci U S A. 1998 Jul 21;95(15):8744-9
  • Latest
    J:242138 Peracchi A, et al., Nit1 is a metabolite repair enzyme that hydrolyzes deaminated glutathione. Proc Natl Acad Sci U S A. 2017 Apr 18;114(16):E3233-E3242
Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
Citing These Resources
Funding Information
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Send questions and comments to User Support. 		last database update
09/08/2026
MGI 6.24 		The Jackson Laboratory