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Sec23a Gene Detail
Summary
  • Symbol
    Sec23a
  • Name
    SEC23 homolog A, COPII coat complex component
  • Synonyms
    Msec23, Sec23r
  • Feature Type
    protein coding gene
  • IDs
    MGI:1349635
    NCBI Gene: 20334
  • Alliance
    gene page
  • Transcription Start Sites
    5 TSS
Location &
Maps
more
  • Sequence Map
    Chr12:59005170-59058803 bp, - strand
    From NCBI annotation of GRCm39
  • View this region in JBrowse
  • Genome Browsers
    Ensembl | UCSC | NCBI
  • Genetic Map
    Chromosome 12, 25.97 cM
  • Mapping Data
    5 experiments
Strain
Comparison
more
  • SNPs within 2kb
    610 from dbSNP Build 142
  • Strain Annotations
    18
For selected strains:
Strain Gene Model ID Feature Type Coordinates Select Strains
C57BL/6J MGI_C57BL6J_1349635
 protein coding gene Chr12:59005169-59058803 (-)
129S1/SvImJ MGP_129S1SvImJ_G0019765
 protein coding gene Chr12:58150136-58205859 (-)
A/J MGP_AJ_G0019724
 protein coding gene Chr12:56038039-56093253 (-)
AKR/J MGP_AKRJ_G0019699
 protein coding gene Chr12:57816477-57875204 (-)
BALB/cJ MGP_BALBcJ_G0019704
 protein coding gene Chr12:56420436-56474491 (-)
C3H/HeJ MGP_C3HHeJ_G0019509
 protein coding gene Chr12:57918058-57973753 (-)
C57BL/6NJ MGP_C57BL6NJ_G0020156
 protein coding gene Chr12:59855881-59911423 (-)
CAROLI/EiJ MGP_CAROLIEiJ_G0017776
 protein coding gene Chr12:54413888-54466062 (-)
CAST/EiJ MGP_CASTEiJ_G0019061
 protein coding gene Chr12:52807719-52862483 (-)
CBA/J MGP_CBAJ_G0019478
 protein coding gene Chr12:62055527-62121762 (-)
DBA/2J MGP_DBA2J_G0019594
 protein coding gene Chr12:55954659-56007937 (-)
FVB/NJ MGP_FVBNJ_G0019582
 protein coding gene Chr12:55220197-55278052 (-)
LP/J MGP_LPJ_G0019666
 protein coding gene Chr12:58189599-58246638 (-)
NOD/ShiLtJ MGP_NODShiLtJ_G0019620
 protein coding gene Chr12:63668946-63727509 (-)
NZO/HlLtJ MGP_NZOHlLtJ_G0020190
 protein coding gene Chr12:57263668-57318966 (-)
PWK/PhJ MGP_PWKPhJ_G0018828
 protein coding gene Chr12:50317824-50373571 (-)
SPRET/EiJ MGP_SPRETEiJ_G0018621
 protein coding gene Chr12:51666863-51719804 (-)
WSB/EiJ MGP_WSBEiJ_G0019112
 protein coding gene Chr12:57828630-57885540 (-)



Homology
more
  • Human Ortholog
    SEC23A, SEC23 homolog A, COPII coat complex component
  • Vertebrate Orthologs
    3
Vertebrate Orthology Source
Alliance of Genome Resources
  • Human Ortholog
    SEC23A, SEC23 homolog A, COPII coat complex component
  • Synonyms
    CLSD, hSec23A
  • Links
    NCBI Gene ID: 10484
    neXtProt AC: NX_Q15436
    UniProt: Q15436

  • Chr Location
    14q21.1; chr14:39031919-39109646 (-)  GRCh38
Human Diseases
more
  • Diseases
    1 with human SEC23A associations

Human Disease Mouse Models
      
IDs
Click on a disease name to see all genes associated with that disease.

Mutations,
Alleles, and
Phenotypes
less
  • Phenotype Summary
    18 phenotypes from 2 alleles in 2 genetic backgrounds
    4 phenotypes from multigenic genotypes
    10 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
integument
immune system
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
neoplasm
vision/eye

Click cells to view annotations.
Mice homozygous for a knock-out allele die during mid-embryogenesis exhibiting defects in neural tube closure and extraembryonic membrane formation as well as broad secretion defects of multiple collagen species in different tissues.
Gene Ontology
(GO)
Classifications
less
  • All GO Annotations
    26
  • GO References
    11
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
RNA binding
signaling receptor activity
signaling receptor binding
transcription
transferase
transporter
Biological Process

carbohydrate derivative metabolism
cell differentiation
cell population proliferation
cellular component organization
DNA-templated transcription
establishment of localization
homeostatic process
immune system process
lipid metabolic process
programmed cell death
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
non-membrane-bounded organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
protein-containing complex
synapse
vacuole
Click cells to view annotations.
Expression
less
Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
    810
  • Tissues
    36
  • cDNA Data
    8
  • Literature Summary
    9
  • Comparison Matrix
    Gene Expression + Phenotype
    • Sequences &
    Gene Models
    less
    Representative SequencesLengthStrain/SpeciesFlank
    genomic 20334 NCBI Gene Model | MGI Sequence Detail 53634 C57BL/6J ±  kb
    transcript NM_009147 RefSeq | MGI Sequence Detail 4108 C57BL/6  
    polypeptide Q01405 UniProt | EBI | MGI Sequence Detail 765 Not Applicable  
    For the selected sequence
    Protein
    Information
    less
    Molecular
    Reagents
    less
    • All nucleic 10
      cDNA 8
      Primer pair 2

      Microarray probesets 4
    Other
    Accession IDs
    less
    MGD-MRK-14354, MGI:98275
    References
    more
    • Summaries
      All 53
      Developmental Gene Expression 9
      Gene Ontology 11
      Phenotypes 10
    • Earliest
      J:3745 Carding SR, et al., Activation of cytokine genes in T cells during primary and secondary murine influenza pneumonia. J Exp Med. 1993 Feb 1;177(2):475-82
    • Latest
      J:281567 Ariyasu D, et al., Decreased Activity of the Ghrhr and Gh Promoters Causes Dominantly Inherited GH Deficiency in Humanized GH1 Mouse Models. Endocrinology. 2019 Nov 1;160(11):2673-2691
    Contributing Projects:
    Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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    Send questions and comments to User Support.     		last database update
    04/09/2024
    MGI 6.23     		The Jackson Laboratory