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Uba7 Gene Detail
Summary
  • Symbol
    Uba7
  • Name
    ubiquitin-like modifier activating enzyme 7
  • Synonyms
    1300004C08Rik, Ube1l
  • Feature Type
    protein coding gene
  • IDs
    MGI:1349462
    NCBI Gene: 74153
  • Alliance
    genome feature page
  • Transcription Start Sites
    7 TSS
Location &
Maps
more
  • Sequence Map
    Chr9:107852766-107861255 bp, + strand
    From NCBI annotation of GRCm39
  • View this region in JBrowse
  • Genome Browsers
    Ensembl | UCSC | NCBI
  • Genetic Map
    Chromosome 9, 59.07 cM
  • Mapping Data
    2 experiments
Strain
Comparison
more
  • SNPs within 2kb
    197 from dbSNP Build 142
  • Strain Annotations
    19
For selected strains:
Strain Gene Model ID Feature Type Coordinates Select Strains
C57BL/6J MGI_C57BL6J_1349462
 protein coding gene Chr9:107852704-107861259 (+)
129S1/SvImJ ENSMUSG00200041836
 protein coding gene Chr9:105050697-105059224 (+)
A/J ENSMUSG00195038381
 protein coding gene Chr9:104269318-104277844 (+)
AKR/J ENSMUSG00220022983
 protein coding gene Chr9:104656357-104664884 (+)
BALB/cJ ENSMUSG00180029677
 protein coding gene Chr9:104585834-104594360 (+)
C3H/HeJ ENSMUSG00175034283
 protein coding gene Chr9:104928127-104936653 (+)
C57BL/6NJ ENSMUSG00215023460
 protein coding gene Chr9:104905334-104913860 (+)
CAROLI/EiJ MGP_CAROLIEiJ_G0032667
 protein coding gene Chr9:103312859-103321476 (+)
CAST/EiJ ENSTCUG00005029148
 protein coding gene Chr9:104679321-104687948 (+)
CBA/J ENSMUSG00210036262
 protein coding gene Chr9:104777670-104786178 (+)
DBA/2J ENSMUSG00185030853
 protein coding gene Chr9:104937154-104945681 (+)
FVB/NJ ENSMUSG00205027196
 protein coding gene Chr9:104938870-104947396 (+)
JF1/MsJ ENSUMUG00000046863
 protein coding gene Chr9:104766897-104775405 (+)
LP/J ENSMUSG00230044578
 protein coding gene Chr9:105079594-105088121 (+)
NOD/ShiLtJ ENSMUSG00190025623
 protein coding gene Chr9:104576003-104584529 (+)
NZO/HlLtJ ENSMUSG00225022550
 protein coding gene Chr9:105310442-105318969 (+)
PWK/PhJ ENSLUMG00010033141
 protein coding gene Chr9:104723936-104732446 (+)
SPRET/EiJ ENSMSPG00010041677
 protein coding gene Chr9:106553972-106562507 (+)
WSB/EiJ ENSIUOG00005034384
 protein coding gene Chr9:104022646-104031173 (+)



Homology
more
  • Human Ortholog
    UBA7, ubiquitin like modifier activating enzyme 7
  • Vertebrate Orthologs
    3
Vertebrate Orthology Source
Alliance of Genome Resources
  • Human Ortholog
    UBA7, ubiquitin like modifier activating enzyme 7
  • Synonyms
    D8, UBA1B, UBE1L, UBE2, UBE7
  • Links
    NCBI Gene ID: 7318
    UniProt: P41226

  • Chr Location
    3p21.31; chr3:49805205-49814151 (-)  GRCh38
Mutations,
Alleles, and
Phenotypes
less
  • Phenotype Summary
    1 phenotype from 1 allele in 1 genetic background
    1 phenotype from multigenic genotypes
    19 phenotype references
Homozygous null mice lacking ISG15 conjugation but not free ISG15 are healthy and fertile and exhibit normal antiviral responses against vesicular stomatitis virus and lymphocytic choriomeningitis virus infection. Bone-derived macrophages from mutant mice display normal responses to IFN treatment.
Gene Ontology
(GO)
Classifications
less
  • All GO Annotations
    27
  • GO References
    11
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
RNA binding
signaling receptor activity
signaling receptor binding
transcription
transferase
transporter
Biological Process

carbohydrate derivative metabolism
cell differentiation
cell population proliferation
cellular component organization
DNA-templated transcription
establishment of localization
homeostatic process
immune system process
lipid metabolic process
programmed cell death
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
membraneless organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
protein-containing complex
synapse
vacuole
Click cells to view annotations.
Expression
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Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
    626
  • Tissues
    2
  • cDNA Data
    55
  • Literature Summary
    1
Sequences &
Gene Models
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Representative SequencesLengthStrain/SpeciesFlank
genomic 74153 NCBI Gene Model | MGI Sequence Detail 8490 C57BL/6J ±  kb
transcript NM_023738 RefSeq | MGI Sequence Detail 3162 C57BL/6  
polypeptide Q9DBK7 UniProt | EBI | MGI Sequence Detail 977 Not Applicable  
For the selected sequence
Protein
Information
less
  • UniProt
    6 Sequences
  • Protein Ontology
    PR:000016956 ubiquitin-like modifier-activating enzyme 7
    (term hierarchy)
  • EC
    6.2.1.-
  • InterPro Domains
    IPR045886 ThiF/MoeB/HesA family
    IPR000594 THIF-type NAD/FAD binding fold
    IPR018075 Ubiquitin-activating enzyme E1
    IPR018965 Ubiquitin-activating enzyme E1, C-terminal
    IPR038252 Ubiquitin-activating enzyme E1, C-terminal domain superfamily
    IPR032418 Ubiquitin-activating enzyme E1, FCCH domain
    IPR042302 Ubiquitin-activating enzyme E1, FCCH domain superfamily
    IPR032420 Ubiquitin-activating enzyme E1, four-helix bundle
    IPR042449 Ubiquitin-activating enzyme E1, inactive adenylation domain, subdomain 1
    IPR042063 Ubiquitin-activating enzyme E1, SCCH domain
    IPR035985 Ubiquitin-activating enzyme-like
    IPR019572 Ubiquitin-activating enzyme, SCCH domain
    IPR000011 Ubiquitin/SUMO-activating enzyme E1-like
Molecular
Reagents
less
  • All nucleic 56
    Genomic 1
    cDNA 55

    Microarray probesets 5
Other
Accession IDs
less
MGI:1921403
References
more
  • Summaries
    All 51
    Developmental Gene Expression 1
    Gene Ontology 11
    Phenotypes 19
  • Earliest
    J:57881 Persons DA, et al., Fv2 encodes a truncated form of the Stk receptor tyrosine kinase [see comments]. Nat Genet. 1999 Oct;23(2):159-65
  • Latest
    J:326541 Cyagen Biosciences Inc., Cyagen Biosciences Website. 2022;
Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
Citing These Resources
Funding Information
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Send questions and comments to User Support. 		last database update
09/01/2026
MGI 6.24 		The Jackson Laboratory