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Cops4 Gene Detail
Summary
  • Symbol
    Cops4
  • Name
    COP9 signalosome subunit 4
  • Synonyms
    COP9 complex S4, D5Ertd774e
  • Feature Type
    protein coding gene
  • IDs
    MGI:1349414
    NCBI Gene: 26891
  • Alliance
    genome feature page
  • Transcription Start Sites
    2 TSS
Location &
Maps
more
  • Sequence Map
    Chr5:100666223-100695668 bp, + strand
    From NCBI annotation of GRCm39
  • View this region in JBrowse
  • Genome Browsers
    Ensembl | UCSC | NCBI
  • Genetic Map
    Chromosome 5, 48.49 cM
  • Mapping Data
    3 experiments
Strain
Comparison
more
  • SNPs within 2kb
    765 from dbSNP Build 142
  • Strain Annotations
    27
For selected strains:
Strain Gene Model ID Feature Type Coordinates Select Strains
C57BL/6J MGI_C57BL6J_1349414
 protein coding gene Chr5:100666175-100695669 (+)
129S1/SvImJ ENSMUSG00200005336
 protein coding gene Chr5:94423172-94432553 (+)
129S1/SvImJ ENSMUSGG00200054719
 protein coding gene Chr5:94408227-94413845 (+)
A/J ENSMUSG00195032351
 protein coding gene Chr5:93974229-93979836 (+)
A/J ENSMUSGG00195055226
 protein coding gene Chr5:93983713-93993092 (+)
AKR/J ENSMUSGG00220054632
 protein coding gene Chr5:93453209-93462589 (+)
AKR/J ENSMUSG00220034061
 protein coding gene Chr5:93443725-93449332 (+)
BALB/cJ ENSMUSGG00180055341
 protein coding gene Chr5:94139861-94149240 (+)
BALB/cJ ENSMUSG00180029796
 protein coding gene Chr5:94130377-94135984 (+)
C3H/HeJ ENSMUSGG00175054761
 protein coding gene Chr5:96244444-96253823 (+)
C3H/HeJ ENSMUSG00175032157
 protein coding gene Chr5:96234960-96240567 (+)
C57BL/6NJ ENSMUSGG00215055543
 protein coding gene Chr5:94061417-94070797 (+)
C57BL/6NJ ENSMUSG00215007943
 protein coding gene Chr5:94051913-94057520 (+)
CAROLI/EiJ MGP_CAROLIEiJ_G0027453
 protein coding gene Chr5:93447448-93480949 (+)
CAST/EiJ no annotation
CBA/J ENSMUSG00210031627
 protein coding gene Chr5:94985305-94990912 (+)
CBA/J ENSMUSGG00210054863
 protein coding gene Chr5:94994789-95004168 (+)
DBA/2J ENSMUSG00185034196
 protein coding gene Chr5:97903644-97909251 (+)
DBA/2J ENSMUSGG00185057393
 protein coding gene Chr5:97913128-97922507 (+)
FVB/NJ ENSMUSGG00205054481
 protein coding gene Chr5:93889965-93899345 (+)
FVB/NJ ENSMUSG00205020473
 protein coding gene Chr5:93880481-93886088 (+)
JF1/MsJ no annotation
LP/J ENSMUSGG00230055572
 protein coding gene Chr5:101949870-101955492 (+)
LP/J ENSMUSG00230028443
 protein coding gene Chr5:101964819-101974200 (+)
NOD/ShiLtJ ENSMUSGG00190054945
 protein coding gene Chr5:93891925-93901305 (+)
NOD/ShiLtJ ENSMUSG00190020721
 protein coding gene Chr5:93882423-93888028 (+)
NZO/HlLtJ ENSMUSG00225012329
 protein coding gene Chr5:109719481-109725088 (+)
NZO/HlLtJ ENSMUSGG00225055655
 protein coding gene Chr5:109728965-109738344 (+)
PWK/PhJ no annotation
SPRET/EiJ ENSMSPG00010024728
 protein coding gene Chr5:95879612-95908784 (+)
WSB/EiJ no annotation



Homology
more
  • Human Ortholog
    COPS4, COP9 signalosome subunit 4
  • Vertebrate Orthologs
    3
Vertebrate Orthology Source
Alliance of Genome Resources
  • Human Ortholog
    COPS4, COP9 signalosome subunit 4
  • Synonyms
    CSN4, SGN4
  • Links
    NCBI Gene ID: 51138
    UniProt: Q9BT78

  • Chr Location
    4q21.22; chr4:83034447-83075818 (+)  GRCh38
Mutations,
Alleles, and
Phenotypes
less
  • Phenotype Summary
    5 phenotypes from 1 allele in 1 genetic background
    17 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
integument
immune system
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
neoplasm
vision/eye

Click cells to view annotations.
Gene Ontology
(GO)
Classifications
less
  • All GO Annotations
    32
  • GO References
    8
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
RNA binding
signaling receptor activity
signaling receptor binding
transcription
transferase
transporter
Biological Process

carbohydrate derivative metabolism
cell differentiation
cell population proliferation
cellular component organization
DNA-templated transcription
establishment of localization
homeostatic process
immune system process
lipid metabolic process
programmed cell death
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
membraneless organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
protein-containing complex
synapse
vacuole
Click cells to view annotations.
Expression
less
Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
    622
  • Tissues
    22
  • cDNA Data
    194
  • Literature Summary
    3
  • Comparison Matrix
    Gene Expression + Phenotype
    • Sequences &
    Gene Models
    less
    Representative SequencesLengthStrain/SpeciesFlank
    genomic 26891 NCBI Gene Model | MGI Sequence Detail 29446 C57BL/6J ±  kb
    transcript NM_001359204 RefSeq | MGI Sequence Detail 1706 C57BL/6  
    polypeptide O88544 UniProt | EBI | MGI Sequence Detail 406 Not Applicable  
    For the selected sequence
    Protein
    Information
    less
    • UniProt
      7 Sequences
    • Protein Ontology
      PR:000005741 COP9 signalosome complex subunit 4
      (term hierarchy)
    • PDB
      1UFM
    • InterPro Domains
      IPR040134 26S Proteasome non-ATPase regulatory subunit 12/COP9 signalosome complex subunit 4
      IPR041406 COP9 signalosome complex subunit 4, helix turn helix domain
      IPR000717 Proteasome component (PCI) domain
      IPR054559 PSMD12/CSN4-like, N-terminal
      IPR036390 Winged helix DNA-binding domain superfamily
      IPR036388 Winged helix-like DNA-binding domain superfamily
    • GlyGen
      O88544 1 site, 1 N-linked glycan (1 site)
    Molecular
    Reagents
    less
    • All nucleic 195
      cDNA 194
      Primer pair 1

      Microarray probesets 3
    Other
    Accession IDs
    less
    MGI:1289319, MGI:2141171
    References
    more
    • Summaries
      All 58
      Developmental Gene Expression 3
      Gene Ontology 8
      Phenotypes 17
    • Earliest
      J:134667 Roderick TH, et al., Two radiation-induced chromosomal inversions in mice (Mus musculus). Proc Natl Acad Sci U S A. 1970 Oct;67(2):961-7
    • Latest
      J:345621 Adams DJ, et al., Genetic determinants of micronucleus formation in vivo. Nature. 2024 Mar;627(8002):130-136
    Contributing Projects:
    Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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    Funding Information
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    Send questions and comments to User Support.     		last database update
    09/08/2026
    MGI 6.24     		The Jackson Laboratory