About   Help   FAQ
Triobp Gene Detail
Summary
  • Symbol
    Triobp
  • Name
    TRIO and F-actin binding protein
  • Synonyms
    EST478828, Mus EST 478828, Tara
  • Feature Type
    protein coding gene
  • IDs
    MGI:1349410
    NCBI Gene: 110253
  • Alliance
    genome feature page
  • Transcription Start Sites
    19 TSS
Location &
Maps
more
  • Sequence Map
    Chr15:78831924-78890069 bp, + strand
    From NCBI annotation of GRCm39
  • View this region in JBrowse
  • Genome Browsers
    Ensembl | UCSC | NCBI
  • Genetic Map
    Chromosome 15, 37.70 cM
  • Mapping Data
    3 experiments
Strain
Comparison
more
  • SNPs within 2kb
    1601 from dbSNP Build 142
  • Strain Annotations
    18
For selected strains:
Strain Gene Model ID Feature Type Coordinates Select Strains
C57BL/6J MGI_C57BL6J_1349410
 protein coding gene Chr15:78831924-78890069 (+)
129S1/SvImJ ENSMUSGG00200054954
 protein coding gene Chr15:75948064-75966291 (+)
129S1/SvImJ ENSMUSG00200048448
 protein coding gene Chr15:75980367-76002106 (+)
A/J ENSMUSG00195048104
 protein coding gene Chr15:75922024-75943704 (+)
AKR/J ENSMUSG00220050426
 protein coding gene Chr15:75965449-75987127 (+)
BALB/cJ ENSMUSG00180047261
 protein coding gene Chr15:75799026-75820707 (+)
C3H/HeJ ENSMUSG00175046948
 protein coding gene Chr15:76110316-76131996 (+)
C57BL/6NJ ENSMUSG00215051595
 protein coding gene Chr15:75877429-75899116 (+)
C57BL/6NJ ENSMUSGG00215055817
 protein coding gene Chr15:75845413-75863353 (+)
CAROLI/EiJ MGP_CAROLIEiJ_G0019999
 protein coding gene Chr15:72946569-73005851 (+)
CAST/EiJ no annotation
CBA/J ENSMUSG00210045157
 protein coding gene Chr15:75885431-75907109 (+)
DBA/2J ENSMUSG00185039336
 protein coding gene Chr15:75895321-75917001 (+)
FVB/NJ ENSMUSG00205047416
 protein coding gene Chr15:75615140-75636822 (+)
JF1/MsJ no annotation
LP/J ENSMUSGG00230055881
 protein coding gene Chr15:79196487-79214726 (+)
LP/J ENSMUSG00230051504
 protein coding gene Chr15:79228800-79250536 (+)
NOD/ShiLtJ ENSMUSG00190046846
 protein coding gene Chr15:75873952-75928001 (+)
NZO/HlLtJ ENSMUSG00225053185
 protein coding gene Chr15:79556993-79578677 (+)
PWK/PhJ no annotation
SPRET/EiJ ENSMSPG00010042367
 protein coding gene Chr15:77320455-77382145 (+)
WSB/EiJ no annotation



Homology
more
  • Human Ortholog
    TRIOBP, TRIO and F-actin binding protein
  • Vertebrate Orthologs
    4
Vertebrate Orthology Source
Alliance of Genome Resources
  • Human Ortholog
    TRIOBP, TRIO and F-actin binding protein
  • Synonyms
    DFNB28, dJ37E16.4, HRIHFB2122, TAP68, TARA
  • Links
    NCBI Gene ID: 11078
    UniProt: Q9H2D6

  • Chr Location
    22q13.1; chr22:37697048-37776556 (+)  GRCh38
Human Diseases
more
  • Diseases
    1 with Triobp mouse models; 1 with human TRIOBP associations

Human Disease Mouse Models
      
IDs
 View 1 model
Click on a disease name to see all genes associated with that disease.

  • Mutations/Alleles
    1 with disease annotations
  • References
    2 with disease annotations
Mutations,
Alleles, and
Phenotypes
less
  • Phenotype Summary
    16 phenotypes from 4 alleles in 3 genetic backgrounds
    36 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
integument
immune system
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
neoplasm
vision/eye

Click cells to view annotations.
Mice homozygous for gene trapped alleles exhibit embryonic lethality. Mice homozygous for a targeted allele eliminating isoforms 4 and 5 exhibit profound deafness associated with stereocilia fragility and degeneration.
Gene Ontology
(GO)
Classifications
less
  • All GO Annotations
    30
  • GO References
    11
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
RNA binding
signaling receptor activity
signaling receptor binding
transcription
transferase
transporter
Biological Process

carbohydrate derivative metabolism
cell differentiation
cell population proliferation
cellular component organization
DNA-templated transcription
establishment of localization
homeostatic process
immune system process
lipid metabolic process
programmed cell death
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
membraneless organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
protein-containing complex
synapse
vacuole
Click cells to view annotations.
Expression
less
Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
    603
  • Tissues
    2
  • cDNA Data
    99
  • Literature Summary
    5
  • Comparison Matrix
    Gene Expression + Phenotype
    • Sequences &
    Gene Models
    less
    Representative SequencesLengthStrain/SpeciesFlank
    genomic 110253 NCBI Gene Model | MGI Sequence Detail 58146 C57BL/6J ±  kb
    transcript NM_001039156 RefSeq | MGI Sequence Detail 7352 ZRU/MplStud  
    polypeptide Q99KW3 UniProt | EBI | MGI Sequence Detail 2014 Not Applicable  
    For the selected sequence
    Protein
    Information
    less
    • UniProt
      7 Sequences
    • Protein Ontology
      PR:000016669 TRIO and F-actin-binding protein
      (term hierarchy)
    • InterPro Domains
      IPR052223 Actin cytoskeleton-regulating protein
      IPR039597 Myosin phosphatase-RhoA interacting protein, PH domain
      IPR011993 PH-like domain superfamily
      IPR001849 Pleckstrin homology domain
    • GlyGen
      Q99KW3 3 sites, 1 O-linked glycan (1 site)
    Molecular
    Reagents
    less
    • All nucleic 99
      cDNA 99
      Antibodies 1

      Microarray probesets 3
    Other
    Accession IDs
    less
    MGI:1349446, MGI:2146002
    References
    more
    • Summaries
      All 77
      Developmental Gene Expression 5
      Diseases 2
      Gene Ontology 11
      Phenotypes 36
    • Earliest
      J:7688 Lane PW, et al., Association of megacolon with a new dominant spotting gene (Dom) in the mouse. J Hered. 1984 Nov-Dec;75(6):435-9
    • Latest
      J:387680 Ahn B, et al., Disorganization of Transcriptional Regulation and Alteration of Keratin Family Gene Expression in Hairy Ear Mice. Genes (Basel). 2026 Jan 31;17(2)
    Contributing Projects:
    Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
    Citing These Resources
    Funding Information
    Warranty Disclaimer, Privacy Notice, Licensing, & Copyright
    Send questions and comments to User Support.     		last database update
    09/01/2026
    MGI 6.24     		The Jackson Laboratory