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Acot1 Gene Detail
Summary
  • Symbol
    Acot1
  • Name
    acyl-CoA thioesterase 1
  • Synonyms
    ACH2, Cte1, CTE-1, CTE-I, D12Ucla1
  • Feature Type
    protein coding gene
  • IDs
    MGI:1349396
    NCBI Gene: 26897
  • Alliance
    gene page
  • Transcription Start Sites
    1 TSS
Location &
Maps
more
  • Sequence Map
    Chr12:84056276-84064444 bp, + strand
    From NCBI annotation of GRCm39
  • View this region in JBrowse
  • Genome Browsers
    Ensembl | UCSC | NCBI
  • Genetic Map
    Chromosome 12, 39.00 cM
  • Mapping Data
    7 experiments
Strain
Comparison
more
  • SNPs within 2kb
    93 from dbSNP Build 142
  • Strain Annotations
    16
  • RFLP
    1
For selected strains:
Strain Gene Model ID Feature Type Coordinates Select Strains
C57BL/6J MGI_C57BL6J_1349396
 protein coding gene Chr12:84056264-84065145 (+)
129S1/SvImJ MGP_129S1SvImJ_G0019923
 protein coding gene Chr12:84679728-84694238 (+)
A/J MGP_AJ_G0019880
 protein coding gene Chr12:81446218-81453518 (+)
AKR/J MGP_AKRJ_G0019856
 protein coding gene Chr12:83680605-83690183 (+)
BALB/cJ MGP_BALBcJ_G0019860
 protein coding gene Chr12:81789376-81794346 (+)
C3H/HeJ MGP_C3HHeJ_G0019666
 protein coding gene Chr12:84144112-84158823 (+)
C57BL/6NJ no annotation
CAROLI/EiJ MGP_CAROLIEiJ_G0017930
 protein coding gene Chr12:78391442-78399751 (+)
CAST/EiJ MGP_CASTEiJ_G0019214
 protein coding gene Chr12:79058730-79065237 (+)
CBA/J MGP_CBAJ_G0019637
 protein coding gene Chr12:90447797-90459176 (+)
DBA/2J MGP_DBA2J_G0019752
 protein coding gene Chr12:81013846-81022872 (+)
FVB/NJ MGP_FVBNJ_G0019738
 protein coding gene Chr12:79965802-79974832 (+)
LP/J MGP_LPJ_G0019824
 protein coding gene Chr12:84561404-84569792 (+)
NOD/ShiLtJ MGP_NODShiLtJ_G0019777
 protein coding gene Chr12:93417856-93426823 (+)
NZO/HlLtJ no annotation
PWK/PhJ MGP_PWKPhJ_G0018979
 protein coding gene Chr12:75497265-75507015 (+)
SPRET/EiJ MGP_SPRETEiJ_G0018774
 protein coding gene Chr12:77756862-77768161 (+)
WSB/EiJ MGP_WSBEiJ_G0019266
 protein coding gene Chr12:83927507-83932779 (+)



Homology
more
  • Human Ortholog
    ACOT1, acyl-CoA thioesterase 1
  • Vertebrate Orthologs
    6
Vertebrate Orthology Source
Alliance of Genome Resources
  • Human Ortholog
    ACOT1, acyl-CoA thioesterase 1
  • Synonyms
    ACH2, CTE-1, LACH2
  • Links
    NCBI Gene ID: 641371
    neXtProt AC: NX_Q86TX2
    UniProt: Q86TX2

  • Chr Location
    chr14:73490933-73543796 (+)  GRCh38
  • Human Ortholog
    ACOT2, acyl-CoA thioesterase 2
  • Synonyms
    CTE1A, CTE-IA, MTE1, PTE2, PTE2A, ZAP128
  • Links
    NCBI Gene ID: 10965
    neXtProt AC: NX_P49753
    UniProt: P49753

  • Chr Location
    14q24.3; chr14:73567620-73575658 (+)  GRCh38
Mutations,
Alleles, and
Phenotypes
less
  • Phenotype Summary
    8 phenotype references
Gene Ontology
(GO)
Classifications
less
  • All GO Annotations
    18
  • GO References
    8
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
RNA binding
signaling receptor activity
signaling receptor binding
transcription
transferase
transporter
Biological Process

carbohydrate derivative metabolism
cell differentiation
cell population proliferation
cellular component organization
DNA-templated transcription
establishment of localization
homeostatic process
immune system process
lipid metabolic process
programmed cell death
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
non-membrane-bounded organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
protein-containing complex
synapse
vacuole
Click cells to view annotations.
Expression
less
Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
    1178
  • Tissues
    128
  • cDNA Data
    107
  • Literature Summary
    8
Sequences &
Gene Models
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Representative SequencesLengthStrain/SpeciesFlank
genomic 26897 NCBI Gene Model | MGI Sequence Detail 8169 C57BL/6J ±  kb
transcript NM_012006 RefSeq | MGI Sequence Detail 1559 ZRU/MplStud  
polypeptide O55137 UniProt | EBI | MGI Sequence Detail 419 Not Applicable  
For the selected sequence
Protein
Information
less
  • UniProt
    3 Sequences
  • EC
    3.1.2.-, 3.1.2.2
  • InterPro Domains
    IPR016662 Acyl-CoA thioesterase, long chain
    IPR042490 Acyl-CoA thioester hydrolase/BAAT, N-terminal
    IPR006862 Acyl-CoA thioester hydrolase/bile acid-CoA amino acid N-acetyltransferase
    IPR029058 Alpha/Beta hydrolase fold
    IPR014940 BAAT/Acyl-CoA thioester hydrolase C-terminal
Molecular
Reagents
less
  • All nucleic 109
    cDNA 108
    Primer pair 1

    Microarray probesets 4
Other
Accession IDs
less
MGD-MRK-3361, MGI:89581
References
more
  • Summaries
    All 50
    Developmental Gene Expression 8
    Gene Ontology 8
    Phenotypes 8
  • Earliest
    J:15567 Warden CH, et al., Linkage mapping of 40 randomly isolated liver cDNA clones in the mouse. Genomics. 1993 Nov;18(2):295-307
  • Latest
    J:340883 Heden TD, et al., ACOT1 deficiency attenuates high-fat diet-induced fat mass gain by increasing energy expenditure. JCI Insight. 2023 Sep 22;8(18):e160987
Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
Citing These Resources
Funding Information
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Send questions and comments to User Support. 		last database update
04/16/2024
MGI 6.23 		The Jackson Laboratory