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Foxd1 Gene Detail
Summary
  • Symbol
    Foxd1
  • Name
    forkhead box D1
  • Synonyms
    BF-2, FREAC4, Hfh10, Hfhbf2
  • Feature Type
    protein coding gene
  • IDs
    MGI:1347463
    NCBI Gene: 15229
  • Alliance
    gene page
  • Transcription Start Sites
    10 TSS
Location &
Maps
more
  • Sequence Map
    Chr13:98490753-98493213 bp, + strand
    From NCBI annotation of GRCm39
  • View this region in JBrowse
  • Genome Browsers
    Ensembl | UCSC | NCBI
  • Genetic Map
    Chromosome 13, 51.96 cM
  • Mapping Data
    3 experiments
Strain
Comparison
more
  • SNPs within 2kb
    4 from dbSNP Build 142
  • Strain Annotations
    18
  • RFLP
    1
For selected strains:
Strain Gene Model ID Feature Type Coordinates Select Strains
C57BL/6J MGI_C57BL6J_1347463
 protein coding gene Chr13:98490750-98495813 (+)
129S1/SvImJ MGP_129S1SvImJ_G0020866
 protein coding gene Chr13:100058151-100060612 (+)
A/J MGP_AJ_G0020820
 protein coding gene Chr13:96243440-96245901 (+)
AKR/J MGP_AKRJ_G0020794
 protein coding gene Chr13:99182306-99184764 (+)
BALB/cJ MGP_BALBcJ_G0020818
 protein coding gene Chr13:96948942-96951403 (+)
C3H/HeJ MGP_C3HHeJ_G0020609
 protein coding gene Chr13:98920926-98923387 (+)
C57BL/6NJ MGP_C57BL6NJ_G0021252
 protein coding gene Chr13:103071075-103073566 (+)
CAROLI/EiJ MGP_CAROLIEiJ_G0018822
 protein coding gene Chr13:91991411-91993885 (+)
CAST/EiJ MGP_CASTEiJ_G0020128
 protein coding gene Chr13:98289792-98292259 (+)
CBA/J MGP_CBAJ_G0020569
 protein coding gene Chr13:107174196-107176654 (+)
DBA/2J MGP_DBA2J_G0020694
 protein coding gene Chr13:96017192-96019650 (+)
FVB/NJ MGP_FVBNJ_G0020675
 protein coding gene Chr13:94777312-94779673 (+)
LP/J MGP_LPJ_G0020769
 protein coding gene Chr13:100162485-100164946 (+)
NOD/ShiLtJ MGP_NODShiLtJ_G0020703
 protein coding gene Chr13:107484011-107486472 (+)
NZO/HlLtJ MGP_NZOHlLtJ_G0021293
 protein coding gene Chr13:98639089-98641550 (+)
PWK/PhJ MGP_PWKPhJ_G0019881
 protein coding gene Chr13:94824283-94835237 (+)
SPRET/EiJ MGP_SPRETEiJ_G0019704
 protein coding gene Chr13:94909046-94911503 (+)
WSB/EiJ MGP_WSBEiJ_G0020185
 protein coding gene Chr13:99078471-99080929 (+)



Homology
more
  • Human Ortholog
    FOXD1, forkhead box D1
  • Vertebrate Orthologs
    2
Vertebrate Orthology Source
Alliance of Genome Resources
  • Human Ortholog
    FOXD1, forkhead box D1
  • Synonyms
    FKHL8, FREAC4, FREAC-4
  • Links
    NCBI Gene ID: 2297
    neXtProt AC: NX_Q16676
    UniProt: Q16676

  • Chr Location
    5q13.2; chr5:73444827-73448777 (-)  GRCh38
Mutations,
Alleles, and
Phenotypes
less
  • Phenotype Summary
    23 phenotypes from 1 allele in 1 genetic background
    4 phenotypes from multigenic genotypes
    99 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
integument
immune system
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
neoplasm
vision/eye

Click cells to view annotations.
Mice homozygous for this targeted mutation die within 24 hours after birth with severe defects in nephrogenesis, and abnormal development of the renal collecting system.
Gene Ontology
(GO)
Classifications
less
  • All GO Annotations
    29
  • GO References
    10
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
RNA binding
signaling receptor activity
signaling receptor binding
transcription
transferase
transporter
Biological Process

carbohydrate derivative metabolism
cell differentiation
cell population proliferation
cellular component organization
DNA-templated transcription
establishment of localization
homeostatic process
immune system process
lipid metabolic process
programmed cell death
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
non-membrane-bounded organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
protein-containing complex
synapse
vacuole
Click cells to view annotations.
Expression
less
Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
    1382
  • Tissues
    358
  • cDNA Data
    28
  • Literature Summary
    140
  • Comparison Matrix
    Gene Expression + Phenotype
    • Sequences &
    Gene Models
    less
    Representative SequencesLengthStrain/SpeciesFlank
    genomic 15229 NCBI Gene Model | MGI Sequence Detail 2461 C57BL/6J ±  kb
    transcript NM_008242 RefSeq | MGI Sequence Detail 2461 ZRU/MplStud  
    polypeptide Q61345 UniProt | EBI | MGI Sequence Detail 456 Not Applicable  
    For the selected sequence
    Protein
    Information
    less
    Molecular
    Reagents
    less
    • All nucleic 45
      cDNA 29
      Primer pair 4
      Other 12

      Microarray probesets 2
    Other
    Accession IDs
    less
    MGD-MRK-16691, MGI:2145223, MGI:99895
    References
    more
    • Summaries
      All 232
      Developmental Gene Expression 140
      Gene Ontology 10
      Phenotypes 99
    • Earliest
      J:20863 Clevidence DE, et al., Identification of nine tissue-specific transcription factors of the hepatocyte nuclear factor 3/forkhead DNA-binding-domain family. Proc Natl Acad Sci U S A. 1993 May 1;90(9):3948-52
    • Latest
      J:345633 Langner E, et al., Cep120 is essential for kidney stromal progenitor cell growth and differentiation. EMBO Rep. 2024 Jan;25(1):428-454
    Contributing Projects:
    Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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    Funding Information
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    Send questions and comments to User Support.     		last database update
    04/16/2024
    MGI 6.23     		The Jackson Laboratory