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Homer3 Gene Detail
Summary
  • Symbol
    Homer3
  • Name
    homer scaffolding protein 3
  • Feature Type
    protein coding gene
  • IDs
    MGI:1347359
    NCBI Gene: 26558
  • Alliance
    gene page
  • Transcription Start Sites
    2 TSS
Location &
Maps
more
  • Sequence Map
    Chr8:70735529-70747011 bp, + strand
    From NCBI annotation of GRCm39
  • View this region in JBrowse
  • Genome Browsers
    Ensembl | UCSC | NCBI
  • Genetic Map
    Chromosome 8, 34.15 cM, cytoband C1
  • Mapping Data
    3 experiments
Strain
Comparison
more
  • SNPs within 2kb
    84 from dbSNP Build 142
  • Strain Annotations
    18
For selected strains:
Strain Gene Model ID Feature Type Coordinates Select Strains
C57BL/6J MGI_C57BL6J_1347359
 protein coding gene Chr8:70735477-70747011 (+)
129S1/SvImJ MGP_129S1SvImJ_G0033698
 protein coding gene Chr8:70546018-70557437 (+)
A/J MGP_AJ_G0033681
 protein coding gene Chr8:67676426-67688020 (+)
AKR/J MGP_AKRJ_G0033606
 protein coding gene Chr8:69603718-69615068 (+)
BALB/cJ MGP_BALBcJ_G0033677
 protein coding gene Chr8:67898107-67909454 (+)
C3H/HeJ MGP_C3HHeJ_G0033387
 protein coding gene Chr8:70247521-70260135 (+)
C57BL/6NJ MGP_C57BL6NJ_G0034194
 protein coding gene Chr8:73216229-73227680 (+)
CAROLI/EiJ MGP_CAROLIEiJ_G0031138
 protein coding gene Chr8:62491407-62503317 (+)
CAST/EiJ MGP_CASTEiJ_G0032712
 protein coding gene Chr8:69731668-69743101 (+)
CBA/J MGP_CBAJ_G0033365
 protein coding gene Chr8:75837985-75850124 (+)
DBA/2J MGP_DBA2J_G0033519
 protein coding gene Chr8:67397642-67409056 (+)
FVB/NJ MGP_FVBNJ_G0033460
 protein coding gene Chr8:66503808-66515989 (+)
LP/J MGP_LPJ_G0033606
 protein coding gene Chr8:70569949-70583422 (+)
NOD/ShiLtJ MGP_NODShiLtJ_G0033503
 protein coding gene Chr8:78506994-78521633 (+)
NZO/HlLtJ MGP_NZOHlLtJ_G0034212
 protein coding gene Chr8:69788774-69800658 (+)
PWK/PhJ MGP_PWKPhJ_G0032420
 protein coding gene Chr8:66690662-66703210 (+)
SPRET/EiJ MGP_SPRETEiJ_G0032256
 protein coding gene Chr8:68753394-68767387 (+)
WSB/EiJ MGP_WSBEiJ_G0032827
 protein coding gene Chr8:70146200-70158812 (+)



Homology
more
  • Human Ortholog
    HOMER3, homer scaffold protein 3
  • Vertebrate Orthologs
    3
Vertebrate Orthology Source
Alliance of Genome Resources
  • Human Ortholog
    HOMER3, homer scaffold protein 3
  • Synonyms
    HOMER-3, VESL3
  • Links
    NCBI Gene ID: 9454
    neXtProt AC: NX_Q9NSC5
    UniProt: Q9NSC5

  • Chr Location
    19p13.11; chr19:18929201-18941261 (-)  GRCh38
Mutations,
Alleles, and
Phenotypes
less
  • Phenotype Summary
    1 phenotype from 1 allele in 1 genetic background
    1 phenotype from multigenic genotypes
    17 phenotype references
  • All Mutations and Alleles
    18
  • Chemically induced (other)
    1
  • Endonuclease-mediated
    1
  • Gene trapped
    13
  • Targeted
    3
  • Genomic Mutations
    1 involving Homer3
  • Find Mice (IMSR)
    39 strains or lines available
Homozygous mutants exhibit normal sensitivity to cocaine.
Gene Ontology
(GO)
Classifications
less
  • All GO Annotations
    25
  • GO References
    12
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
RNA binding
signaling receptor activity
signaling receptor binding
transcription
transferase
transporter
Biological Process

carbohydrate derivative metabolism
cell differentiation
cell population proliferation
cellular component organization
DNA-templated transcription
establishment of localization
homeostatic process
immune system process
lipid metabolic process
programmed cell death
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
non-membrane-bounded organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
protein-containing complex
synapse
vacuole
Click cells to view annotations.
Expression
less
Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
    850
  • Tissues
    78
  • cDNA Data
    14
  • Literature Summary
    3
Sequences &
Gene Models
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Representative SequencesLengthStrain/SpeciesFlank
genomic 26558 NCBI Gene Model | MGI Sequence Detail 11483 C57BL/6J ±  kb
transcript NM_001146153 RefSeq | MGI Sequence Detail 2445 C57BL/6  
polypeptide Q99JP6 UniProt | EBI | MGI Sequence Detail 356 Not Applicable  
For the selected sequence
Protein
Information
less
Molecular
Reagents
less
  • All nucleic 14
    cDNA 14

    Microarray probesets 5
Other
Accession IDs
less
MGI:2142770
References
more
  • Summaries
    All 55
    Developmental Gene Expression 3
    Gene Ontology 12
    Phenotypes 17
  • Earliest
    J:50718 Xiao B, et al., Homer regulates the association of group 1 metabotropic glutamate receptors with multivalent complexes of homer-related, synaptic proteins. Neuron. 1998 Oct;21(4):707-16
  • Latest
    J:323587 Lin R, et al., Homer1a regulates Shank3 expression and underlies behavioral vulnerability to stress in a model of Phelan-McDermid syndrome. Cell Rep. 2021 Nov 16;37(7):110014
Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
Citing These Resources
Funding Information
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Send questions and comments to User Support. 		last database update
04/16/2024
MGI 6.23 		The Jackson Laboratory