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Slc7a11 Gene Detail
Summary
  • Symbol
    Slc7a11
  • Name
    solute carrier family 7 (cationic amino acid transporter, y+ system), member 11
  • Synonyms
    9930009M05Rik, sut, System xc, xc, xCT
  • Feature Type
    protein coding gene
  • IDs
    MGI:1347355
    NCBI Gene: 26570
  • Alliance
  • Transcription Start Sites
    75 TSS
Location &
Maps
more
  • Sequence Map
    Chr3:50319385-50403947 bp, - strand
    From NCBI annotation of GRCm39
  • View this region in JBrowse
  • Genome Browsers
  • Genetic Map
    Chromosome 3, 21.72 cM, cytoband D
  • Mapping Data
    4 experiments
Strain
Comparison
more
  • SNPs within 2kb
    2370 from dbSNP Build 142
  • Strain Annotations
    19
For selected strains:
Strain Gene Model ID Feature Type Coordinates Select Strains
C57BL/6J MGI_C57BL6J_1347355
protein coding gene Chr3:49846975-50403947 (-)
129S1/SvImJ ENSMUSG00200000357
protein coding gene Chr3:47144529-47223196 (-)
A/J ENSMUSG00195000687
protein coding gene Chr3:47113197-47191890 (-)
AKR/J ENSMUSG00220015704
protein coding gene Chr3:47167208-47245905 (-)
BALB/cJ ENSMUSG00180000362
protein coding gene Chr3:47190619-47269300 (-)
C3H/HeJ ENSMUSG00175002078
protein coding gene Chr3:47022087-47100761 (-)
C57BL/6NJ ENSMUSG00215000495
protein coding gene Chr3:47448318-47526991 (-)
CAROLI/EiJ MGP_CAROLIEiJ_G0024970
protein coding gene Chr3:43647845-44180734 (-)
CAST/EiJ ENSTCUG00005009249
protein coding gene Chr3:46852492-46931139 (-)
CBA/J ENSMUSG00210000476
protein coding gene Chr3:47135068-47213717 (-)
DBA/2J ENSMUSG00185000242
protein coding gene Chr3:47375146-47453842 (-)
FVB/NJ ENSMUSG00205009359
protein coding gene Chr3:46364749-46443435 (-)
JF1/MsJ ENSUMUG00000016003
protein coding gene Chr3:46790733-46869415 (-)
LP/J ENSMUSG00230000287
protein coding gene Chr3:49316861-49395526 (-)
NOD/ShiLtJ ENSMUSG00190000182
protein coding gene Chr3:47504930-47583825 (-)
NZO/HlLtJ ENSMUSG00225015953
protein coding gene Chr3:51941804-52020468 (-)
PWK/PhJ ENSLUMG00010009164
protein coding gene Chr3:46951566-47030216 (-)
SPRET/EiJ ENSMSPG00010007000
protein coding gene Chr3:47615573-47687328 (-)
WSB/EiJ ENSIUOG00005000376
protein coding gene Chr3:47306651-47385331 (-)



Homology
more
  • Human Ortholog
    SLC7A11, solute carrier family 7 member 11
  • Vertebrate Orthologs
    3
Vertebrate Orthology Source
Alliance of Genome Resources
  • Human Ortholog
    SLC7A11, solute carrier family 7 member 11
  • Synonyms
    CCBR1, xCT
  • Links
    NCBI Gene ID: 23657
    UniProt: Q9UPY5

  • Chr Location
    4q28.3; chr4:138164097-138242349 (-)  GRCh38

Human Diseases
more
  • Diseases
    2 with Slc7a11 mouse models

Human Disease Mouse Models
      
IDs
View 1 model
IDs
View 1 model
Click on a disease name to see all genes associated with that disease.

  • Mutations/Alleles
    1 with disease annotations
  • References
    2 with disease annotations
Mutations,
Alleles, and
Phenotypes
less
  • Phenotype Summary
    15 phenotypes from 4 alleles in 4 genetic backgrounds
    69 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
integument
immune system
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
neoplasm
vision/eye

Click cells to view annotations.
Homozygous mutant mice show a reduction in yellow pigment resulting in dilution of agouti; only pinna hairs are affected in nonagouti mice. Mice homozygous for an ENU-induced allele exhibit decreased survival of LPS-induced macrophages and increased incidence of chemically-induced tumors.
Gene Ontology
(GO)
Classifications
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  • All GO Annotations
  • GO References
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
RNA binding
signaling receptor activity
signaling receptor binding
transcription
transferase
transporter
Biological Process

carbohydrate derivative metabolism
cell differentiation
cell population proliferation
cellular component organization
DNA-templated transcription
establishment of localization
homeostatic process
immune system process
lipid metabolic process
programmed cell death
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
membraneless organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
protein-containing complex
synapse
vacuole
Click cells to view annotations.
Expression
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Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
  • Tissues
  • cDNA Data
  • Literature Summary
  • Comparison Matrix
  • Sequences &
    Gene Models
    less
    Representative SequencesLengthStrain/SpeciesFlank
    genomic 26570 NCBI Gene Model | MGI Sequence Detail 84563 C57BL/6J ±  kb
    transcript NM_011990 RefSeq | MGI Sequence Detail 9227 Not Specified  
    polypeptide Q9WTR6 UniProt | EBI | MGI Sequence Detail 502 Not Applicable  
    For the selected sequence
    Protein
    Information
    less
    Molecular
    Reagents
    less
    • All nucleic 26
      cDNA 23
      Primer pair 3
      Antibodies 1

      Microarray probesets 6
    Other
    Accession IDs
    less
    MGD-MRK-14656, MGI:2139719, MGI:2442155, MGI:98448
    References
    more
    • Summaries
      All 145
      Developmental Gene Expression 9
      Diseases 2
      Gene Ontology 22
      Phenotypes 69
    • Earliest
      J:64276 Lyon MF, et al., Dose-response curves for radiation-induced gene mutations in mouse oocytes and their interpretation. Mutat Res. 1979 Nov;63(1):161-73
    • Latest
      J:389488 Drekolia MK, et al., Cystine import and oxidative catabolism fuel vascular growth and repair via nutrient-responsive histone acetylation. Cell Metab. 2025 Oct 31;

    Contributing Projects:
    Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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    Funding Information
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    last database update
    09/01/2026
    MGI 6.24
    The Jackson Laboratory