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Grk6 Gene Detail
Summary
  • Symbol
    Grk6
  • Name
    G protein-coupled receptor kinase 6
  • Synonyms
    Gprk6
  • Feature Type
    protein coding gene
  • IDs
    MGI:1347078
    NCBI Gene: 26385
  • Alliance
    genome feature page
  • Transcription Start Sites
    3 TSS
Location &
Maps
more
  • Sequence Map
    Chr13:55592885-55608740 bp, + strand
    From Ensembl annotation of GRCm39
  • View this region in JBrowse
  • Genome Browsers
    Ensembl | UCSC | NCBI
  • Genetic Map
    Chromosome 13, 30.06 cM, cytoband B1-3
  • Mapping Data
    5 experiments
Strain
Comparison
more
  • SNPs within 2kb
    376 from dbSNP Build 142
  • Strain Annotations
    19
  • PCR
    1
  • RFLP
    1
For selected strains:
Strain Gene Model ID Feature Type Coordinates Select Strains
C57BL/6J MGI_C57BL6J_1347078
 protein coding gene Chr13:55592865-55608740 (+)
129S1/SvImJ ENSMUSG00200015658
 protein coding gene Chr13:52465457-52481312 (+)
A/J ENSMUSG00195042737
 protein coding gene Chr13:51924222-51940064 (+)
AKR/J ENSMUSG00220041077
 protein coding gene Chr13:51472836-51488694 (+)
BALB/cJ ENSMUSG00180015758
 protein coding gene Chr13:52175481-52191325 (+)
C3H/HeJ ENSMUSG00175033885
 protein coding gene Chr13:51961939-51977781 (+)
C57BL/6NJ ENSMUSG00215029739
 protein coding gene Chr13:51994918-52010778 (+)
CAROLI/EiJ MGP_CAROLIEiJ_G0018563
 protein coding gene Chr13:50838458-50854154 (+)
CAST/EiJ ENSTCUG00005038729
 protein coding gene Chr13:52387273-52403325 (+)
CBA/J ENSMUSG00210038825
 protein coding gene Chr13:52166757-52182599 (+)
DBA/2J ENSMUSG00185015732
 protein coding gene Chr13:53016795-53032649 (+)
FVB/NJ ENSMUSG00205023360
 protein coding gene Chr13:51819554-51835410 (+)
JF1/MsJ ENSUMUG00000021494
 protein coding gene Chr13:52408167-52424156 (+)
LP/J ENSMUSG00230031253
 protein coding gene Chr13:62358853-62374685 (+)
NOD/ShiLtJ ENSMUSG00190026996
 protein coding gene Chr13:52059722-52075576 (+)
NZO/HlLtJ ENSMUSG00225033843
 protein coding gene Chr13:56088572-56104425 (+)
PWK/PhJ ENSLUMG00010021320
 protein coding gene Chr13:51280130-51296155 (+)
SPRET/EiJ ENSMSPG00010033340
 protein coding gene Chr13:51700423-51716743 (+)
WSB/EiJ ENSIUOG00005021165
 protein coding gene Chr13:51490652-51506491 (+)



Homology
more
  • Human Ortholog
    GRK6, G protein-coupled receptor kinase 6
  • Vertebrate Orthologs
    3
Vertebrate Orthology Source
Alliance of Genome Resources
  • Human Ortholog
    GRK6, G protein-coupled receptor kinase 6
  • Synonyms
    GPRK6
  • Links
    NCBI Gene ID: 2870
    UniProt: P43250

  • Chr Location
    5q35.3; chr5:177403204-177442901 (+)  GRCh38
Human Diseases
more
  • Diseases
    1 with human GRK6 associations

Human Disease Mouse Models
      
IDs
Click on a disease name to see all genes associated with that disease.

  • References
    1 with disease annotations
Mutations,
Alleles, and
Phenotypes
less
  • Phenotype Summary
    19 phenotypes from 1 allele in 2 genetic backgrounds
    35 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
integument
immune system
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
neoplasm
vision/eye

Click cells to view annotations.
Whereas, homozygous mutant mice are viable and show no gross anatomical or behavioral abnormalites under normal physiological conditions, they exhibit locomotor supersensitivity to psychostimulants including cocaine and amphetamine.
Gene Ontology
(GO)
Classifications
less
  • All GO Annotations
    28
  • GO References
    12
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
RNA binding
signaling receptor activity
signaling receptor binding
transcription
transferase
transporter
Biological Process

carbohydrate derivative metabolism
cell differentiation
cell population proliferation
cellular component organization
DNA-templated transcription
establishment of localization
homeostatic process
immune system process
lipid metabolic process
programmed cell death
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
membraneless organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
protein-containing complex
synapse
vacuole
Click cells to view annotations.
Expression
less
Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
    628
  • Tissues
    13
  • cDNA Data
    80
  • Literature Summary
    2
  • Comparison Matrix
    Gene Expression + Phenotype
    • Sequences &
    Gene Models
    less
    Representative SequencesLengthStrain/SpeciesFlank
    genomic ENSMUSG00000074886 Ensembl Gene Model | MGI Sequence Detail 15856 C57BL/6J ±  kb
    transcript ENSMUST00000001115 Ensembl | MGI Sequence Detail 2994 Not Applicable  
    polypeptide ENSMUSP00000001115 Ensembl | MGI Sequence Detail 589 Not Applicable  
    For the selected sequence
    Protein
    Information
    less
    Molecular
    Reagents
    less
    • All nucleic 85
      Genomic 1
      cDNA 80
      Primer pair 2
      Other 2

      Microarray probesets 5
    References
    more
    • Summaries
      All 77
      Developmental Gene Expression 2
      Diseases 1
      Gene Ontology 12
      Phenotypes 35
    • Earliest
      J:182573 Roderick TH, Producing and detecting paracentric chromosomal inversions in mice. Mutat Res. 1971 Jan;11(1):59-69
    • Latest
      J:349923 George K, et al., Robust GRK2/3/6-dependent desensitization of oxytocin receptor in neurons. iScience. 2024 Jun 21;27(6):110047
    Contributing Projects:
    Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
    Citing These Resources
    Funding Information
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    Send questions and comments to User Support.     		last database update
    09/01/2026
    MGI 6.24     		The Jackson Laboratory