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Map3k11 Gene Detail
Summary
  • Symbol
    Map3k11
  • Name
    mitogen-activated protein kinase kinase kinase 11
  • Synonyms
    2610017K16Rik, Mlk3
  • Feature Type
    protein coding gene
  • IDs
    MGI:1346880
    NCBI Gene: 26403
  • Alliance
    gene page
  • Transcription Start Sites
    5 TSS
  • Candidate for QTL
    1 QTL
Location &
Maps
more
  • Sequence Map
    Chr19:5738770-5752893 bp, + strand
    From Ensembl annotation of GRCm39
  • View this region in JBrowse
  • Genome Browsers
    Ensembl | UCSC | NCBI
  • Genetic Map
    Chromosome 19, 4.34 cM
  • Mapping Data
    5 experiments
Strain
Comparison
more
  • SNPs within 2kb
    82 from dbSNP Build 142
  • Strain Annotations
    18
For selected strains:
Strain Gene Model ID Feature Type Coordinates Select Strains
C57BL/6J MGI_C57BL6J_1346880
 protein coding gene Chr19:5738764-5752893 (+)
129S1/SvImJ MGP_129S1SvImJ_G0024722
 protein coding gene Chr19:2673540-2687271 (+)
A/J MGP_AJ_G0024688
 protein coding gene Chr19:2528257-2541991 (+)
AKR/J MGP_AKRJ_G0024661
 protein coding gene Chr19:2594696-2608430 (+)
BALB/cJ MGP_BALBcJ_G0024688
 protein coding gene Chr19:2522652-2536386 (+)
C3H/HeJ MGP_C3HHeJ_G0024456
 protein coding gene Chr19:2612943-2626677 (+)
C57BL/6NJ MGP_C57BL6NJ_G0025135
 protein coding gene Chr19:2740696-2754919 (+)
CAROLI/EiJ MGP_CAROLIEiJ_G0022565
 protein coding gene Chr19:2436991-2450802 (+)
CAST/EiJ MGP_CASTEiJ_G0023928
 protein coding gene Chr19:2632328-2646078 (+)
CBA/J MGP_CBAJ_G0024428
 protein coding gene Chr19:2866671-2880385 (+)
DBA/2J MGP_DBA2J_G0024555
 protein coding gene Chr19:2524194-2537908 (+)
FVB/NJ MGP_FVBNJ_G0024521
 protein coding gene Chr19:2521338-2535437 (+)
LP/J MGP_LPJ_G0024641
 protein coding gene Chr19:2649498-2663221 (+)
NOD/ShiLtJ MGP_NODShiLtJ_G0024551
 protein coding gene Chr19:2711237-2724961 (+)
NZO/HlLtJ MGP_NZOHlLtJ_G0025183
 protein coding gene Chr19:2614932-2628663 (+)
PWK/PhJ MGP_PWKPhJ_G0023674
 protein coding gene Chr19:2546717-2560509 (+)
SPRET/EiJ MGP_SPRETEiJ_G0023479
 protein coding gene Chr19:2599217-2612955 (+)
WSB/EiJ MGP_WSBEiJ_G0023990
 protein coding gene Chr19:2624778-2638490 (+)



Homology
more
  • Human Ortholog
    MAP3K11, mitogen-activated protein kinase kinase kinase 11
  • Vertebrate Orthologs
    2
Vertebrate Orthology Source
Alliance of Genome Resources
  • Human Ortholog
    MAP3K11, mitogen-activated protein kinase kinase kinase 11
  • Synonyms
    MEKK11, MLK3, MLK-3, PTK1, SPRK
  • Links
    NCBI Gene ID: 4296
    neXtProt AC: NX_Q16584
    UniProt: Q16584

  • Chr Location
    11q13.1; chr11:65597756-65615382 (-)  GRCh38
Mutations,
Alleles, and
Phenotypes
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  • Phenotype Summary
    8 phenotypes from 2 alleles in 2 genetic backgrounds
    3 phenotypes from multigenic genotypes
    1 images
    22 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
integument
immune system
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
neoplasm
vision/eye

Click cells to view annotations.
Homozygotes for a targeted or spontaneous mutation display a pattern of dark red stripes of thin dorsal epithelium during pre-wean development, and necrotic dental pulp has been reported for the spontaneous mutant.
Gene Ontology
(GO)
Classifications
less
  • All GO Annotations
    38
  • GO References
    7
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
RNA binding
signaling receptor activity
signaling receptor binding
transcription
transferase
transporter
Biological Process

carbohydrate derivative metabolism
cell differentiation
cell population proliferation
cellular component organization
DNA-templated transcription
establishment of localization
homeostatic process
immune system process
lipid metabolic process
programmed cell death
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
non-membrane-bounded organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
protein-containing complex
synapse
vacuole
Click cells to view annotations.
Expression
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Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
    712
  • Tissues
    3
  • cDNA Data
    8
  • Literature Summary
    4
  • Comparison Matrix
    Gene Expression + Phenotype
    • Sequences &
    Gene Models
    less
    Representative SequencesLengthStrain/SpeciesFlank
    genomic ENSMUSG00000004054 Ensembl Gene Model | MGI Sequence Detail 14124 C57BL/6J ±  kb
    transcript ENSMUST00000004156 Ensembl | MGI Sequence Detail 3898 Not Applicable  
    polypeptide ENSMUSP00000004156 Ensembl | MGI Sequence Detail 850 Not Applicable  
    For the selected sequence
    Protein
    Information
    less
    Molecular
    Reagents
    less
    • All nucleic 12
      Genomic 3
      cDNA 8
      Other 1

      Microarray probesets 3
    Other
    Accession IDs
    less
    MGI:1095739, MGI:1923791
    References
    more
    • Summaries
      All 64
      Developmental Gene Expression 4
      Gene Ontology 7
      Phenotypes 22
    • Earliest
      J:37543 Kiefer F, et al., HPK1, a hematopoietic protein kinase activating the SAPK/JNK pathway. EMBO J. 1996 Dec 16;15(24):7013-25
    • Latest
      J:330866 Liu PW, et al., Mixed lineage kinase 3 requires a functional CRIB domain for regulation of blood pressure, cardiac hypertrophy, and left ventricular function. Am J Physiol Heart Circ Physiol. 2022 Sep 1;323(3):H513-H522
    Contributing Projects:
    Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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    Funding Information
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    Send questions and comments to User Support.     		last database update
    04/16/2024
    MGI 6.23     		The Jackson Laboratory