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Map3k2 Gene Detail
Summary
  • Symbol
    Map3k2
  • Name
    mitogen-activated protein kinase kinase kinase 2
  • Synonyms
    9630061B06Rik, Mekk2, MEK kinase 2
  • Feature Type
    protein coding gene
  • IDs
    MGI:1346873
    NCBI Gene: 26405
  • Alliance
    gene page
  • Transcription Start Sites
    6 TSS
Location &
Maps
more
  • Sequence Map
    Chr18:32296142-32369804 bp, + strand
    From NCBI annotation of GRCm39
  • View this region in JBrowse
  • Genome Browsers
    Ensembl | UCSC | NCBI
  • Genetic Map
    Chromosome 18, 17.95 cM, cytoband B3
  • Mapping Data
    3 experiments
Strain
Comparison
more
  • SNPs within 2kb
    259 from dbSNP Build 142
  • Strain Annotations
    18
For selected strains:
Strain Gene Model ID Feature Type Coordinates Select Strains
C57BL/6J MGI_C57BL6J_1346873
 protein coding gene Chr18:32296142-32369804 (+)
129S1/SvImJ MGP_129S1SvImJ_G0024225
 protein coding gene Chr18:30291369-30368964 (+)
A/J MGP_AJ_G0024191
 protein coding gene Chr18:29283533-29358275 (+)
AKR/J MGP_AKRJ_G0024160
 protein coding gene Chr18:30100530-30177310 (+)
BALB/cJ MGP_BALBcJ_G0024191
 protein coding gene Chr18:29379436-29455924 (+)
C3H/HeJ MGP_C3HHeJ_G0023959
 protein coding gene Chr18:30140398-30218569 (+)
C57BL/6NJ MGP_C57BL6NJ_G0024633
 protein coding gene Chr18:31374605-31453781 (+)
CAROLI/EiJ MGP_CAROLIEiJ_G0022074
 protein coding gene Chr18:29519738-29590921 (+)
CAST/EiJ MGP_CASTEiJ_G0023434
 protein coding gene Chr18:30030478-30109284 (+)
CBA/J MGP_CBAJ_G0023927
 protein coding gene Chr18:32333980-32418650 (+)
DBA/2J MGP_DBA2J_G0024059
 protein coding gene Chr18:28956882-29030738 (+)
FVB/NJ MGP_FVBNJ_G0024025
 protein coding gene Chr18:28664819-28738493 (+)
LP/J MGP_LPJ_G0024140
 protein coding gene Chr18:30376837-30455581 (+)
NOD/ShiLtJ MGP_NODShiLtJ_G0024053
 protein coding gene Chr18:33671333-33759418 (+)
NZO/HlLtJ MGP_NZOHlLtJ_G0024681
 protein coding gene Chr18:29960960-30035922 (+)
PWK/PhJ MGP_PWKPhJ_G0023177
 protein coding gene Chr18:29124272-29200231 (+)
SPRET/EiJ MGP_SPRETEiJ_G0022986
 protein coding gene Chr18:30202487-30279189 (+)
WSB/EiJ MGP_WSBEiJ_G0023497
 protein coding gene Chr18:29866409-29943301 (+)



Homology
more
  • Human Ortholog
    MAP3K2, mitogen-activated protein kinase kinase kinase 2
  • Vertebrate Orthologs
    3
Vertebrate Orthology Source
Alliance of Genome Resources
  • Human Ortholog
    MAP3K2, mitogen-activated protein kinase kinase kinase 2
  • Synonyms
    MEKK2, MEKK2B
  • Links
    NCBI Gene ID: 10746
    neXtProt AC: NX_Q9Y2U5
    UniProt: Q9Y2U5

  • Chr Location
    2q14.3; chr2:127298668-127388465 (-)  GRCh38
Mutations,
Alleles, and
Phenotypes
less
  • Phenotype Summary
    5 phenotypes from 2 alleles in 2 genetic backgrounds
    20 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
integument
immune system
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
neoplasm
vision/eye

Click cells to view annotations.
Mice homozygous for disruptions in this gene are grossly normal and fertile.
Gene Ontology
(GO)
Classifications
less
  • All GO Annotations
    15
  • GO References
    9
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
RNA binding
signaling receptor activity
signaling receptor binding
transcription
transferase
transporter
Biological Process

carbohydrate derivative metabolism
cell differentiation
cell population proliferation
cellular component organization
DNA-templated transcription
establishment of localization
homeostatic process
immune system process
lipid metabolic process
programmed cell death
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
non-membrane-bounded organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
protein-containing complex
synapse
vacuole
Click cells to view annotations.
Expression
less
Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
    896
  • Tissues
    174
  • cDNA Data
    59
  • Literature Summary
    4
  • Comparison Matrix
    Gene Expression + Phenotype
    • Sequences &
    Gene Models
    less
    Representative SequencesLengthStrain/SpeciesFlank
    genomic 26405 NCBI Gene Model | MGI Sequence Detail 73663 C57BL/6J ±  kb
    transcript NM_011946 RefSeq | MGI Sequence Detail 10791 Not Specified  
    polypeptide Q61083 UniProt | EBI | MGI Sequence Detail 619 Not Applicable  
    For the selected sequence
    Protein
    Information
    less
    Molecular
    Reagents
    less
    • All nucleic 61
      cDNA 59
      Primer pair 2

      Microarray probesets 5
    Other
    Accession IDs
    less
    MGD-MRK-39593, MGI:109594, MGI:2147242, MGI:2443659
    References
    more
    • Summaries
      All 69
      Developmental Gene Expression 4
      Gene Ontology 9
      Phenotypes 20
    • Earliest
      J:31860 Blank JL, et al., Molecular cloning of mitogen-activated protein/ERK kinase kinases (MEKK) 2 and 3. Regulation of sequential phosphorylation pathways involving mitogen-activated protein kinase and c-Jun kinase. J Biol Chem. 1996 Mar 8;271(10):5361-8
    • Latest
      J:316856 Wu N, et al., MAP3K2-regulated intestinal stromal cells define a distinct stem cell niche. Nature. 2021 Apr;592(7855):606-610
    Contributing Projects:
    Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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    Funding Information
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    Send questions and comments to User Support.     		last database update
    04/16/2024
    MGI 6.23     		The Jackson Laboratory