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Psmb8 Gene Detail
Summary
  • Symbol
    Psmb8
  • Name
    proteasome (prosome, macropain) subunit, beta type 8 (large multifunctional peptidase 7)
  • Synonyms
    Lmp-7, Lmp7
  • Feature Type
    protein coding gene
  • IDs
    MGI:1346527
    NCBI Gene: 16913
  • Alliance
    genome feature page
  • Transcription Start Sites
    9 TSS
Location &
Maps
more
  • Sequence Map
    Chr17:34417169-34420428 bp, + strand
    From NCBI annotation of GRCm39
  • View this region in JBrowse
  • Genome Browsers
    Ensembl | UCSC | NCBI
  • Genetic Map
    Chromosome 17, 17.98 cM
  • Mapping Data
    3 experiments
Strain
Comparison
more
  • SNPs within 2kb
    5 from dbSNP Build 142
  • Strain Annotations
    19
For selected strains:
Strain Gene Model ID Feature Type Coordinates Select Strains
C57BL/6J MGI_C57BL6J_1346527
 protein coding gene Chr17:34416695-34420428 (+)
129S1/SvImJ ENSMUSG00200045715
 protein coding gene Chr17:30119813-30123543 (+)
A/J ENSMUSG00195046217
 protein coding gene Chr17:30984929-30988631 (+)
AKR/J ENSMUSG00220050730
 protein coding gene Chr17:30012568-30016268 (+)
BALB/cJ ENSMUSG00180027946
 protein coding gene Chr17:30374030-30377757 (+)
C3H/HeJ ENSMUSG00175051940
 protein coding gene Chr17:29898734-29902436 (+)
C57BL/6NJ ENSMUSG00215051811
 protein coding gene Chr17:29959990-29963721 (+)
CAROLI/EiJ MGP_CAROLIEiJ_G0021448
 protein coding gene Chr17:30529604-30533369 (+)
CAST/EiJ ENSTCUG00005050852
 protein coding gene Chr17:30945367-30949040 (+)
CBA/J ENSMUSG00210049974
 protein coding gene Chr17:29720836-29724538 (+)
DBA/2J ENSMUSG00185052100
 protein coding gene Chr17:32393310-32397036 (+)
FVB/NJ ENSMUSG00205034064
 protein coding gene Chr17:30249342-30253018 (+)
JF1/MsJ ENSUMUG00000041237
 protein coding gene Chr17:31657294-31660996 (+)
LP/J ENSMUSG00230053615
 protein coding gene Chr17:33518154-33521888 (+)
NOD/ShiLtJ ENSMUSG00190051019
 protein coding gene Chr17:29873082-29876756 (+)
NZO/HlLtJ ENSMUSG00225054035
 protein coding gene Chr17:35561321-35565086 (+)
PWK/PhJ ENSLUMG00010046107
 protein coding gene Chr17:29509435-29513158 (+)
SPRET/EiJ ENSMSPG00010037423
 protein coding gene Chr17:30642348-30646048 (+)
WSB/EiJ ENSIUOG00005047182
 protein coding gene Chr17:30577354-30581043 (+)



Homology
more
  • Human Ortholog
    PSMB8, proteasome 20S subunit beta 8
  • Vertebrate Orthologs
    3
Vertebrate Orthology Source
Alliance of Genome Resources
  • Human Ortholog
    PSMB8, proteasome 20S subunit beta 8
  • Synonyms
    ALDD, D6S216, D6S216E, JMP, LMP7, NKJO, PRAAS1, PSMB5i, RING10
  • Links
    NCBI Gene ID: 5696
    UniProt: P28062

  • Chr Location
    6p21.32; chr6:32840717-32844679 (-)  GRCh38
Human Diseases
more
  • Diseases
    1 with human PSMB8 associations

Human Disease Mouse Models
      
IDs
Click on a disease name to see all genes associated with that disease.

Mutations,
Alleles, and
Phenotypes
less
  • Phenotype Summary
    4 phenotypes from 1 allele in 3 genetic backgrounds
    6 phenotypes from multigenic genotypes
    82 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
integument
immune system
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
neoplasm
vision/eye

Click cells to view annotations.
Mice homozygous for disruptions in this gene display an essentially normal phenotype. However they have a reduced ability to process MHC class I restricted antigens.
Gene Ontology
(GO)
Classifications
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  • All GO Annotations
    25
  • GO References
    13
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
RNA binding
signaling receptor activity
signaling receptor binding
transcription
transferase
transporter
Biological Process

carbohydrate derivative metabolism
cell differentiation
cell population proliferation
cellular component organization
DNA-templated transcription
establishment of localization
homeostatic process
immune system process
lipid metabolic process
programmed cell death
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
membraneless organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
protein-containing complex
synapse
vacuole
Click cells to view annotations.
Expression
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Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
    603
  • Tissues
    1
  • cDNA Data
    21
  • Literature Summary
    3
Sequences &
Gene Models
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Representative SequencesLengthStrain/SpeciesFlank
genomic 16913 NCBI Gene Model | MGI Sequence Detail 3260 C57BL/6J ±  kb
transcript NM_010724 RefSeq | MGI Sequence Detail 1223 ZRU/MplStud  
polypeptide P28063 UniProt | EBI | MGI Sequence Detail 276 Not Applicable  
For the selected sequence
Protein
Information
less
Molecular
Reagents
less
  • All nucleic 24
    Genomic 3
    cDNA 21

    Microarray probesets 4
Other
Accession IDs
less
MGD-MRK-11822, MGD-MRK-11824, MGI:96798
References
more
  • Summaries
    All 140
    Developmental Gene Expression 3
    Gene Ontology 13
    Phenotypes 82
  • Earliest
    J:8266 Monaco JJ, et al., The LMP antigens: a stable MHC-controlled multisubunit protein complex. Hum Immunol. 1986 Apr;15(4):416-26
  • Latest
    J:386739 Hara T, et al., The homozygous founder Psmb8 variant of Nakajo-Nishimura syndrome/proteasome-associated autoinflammatory syndrome causes panniculitis-associated lipoatrophy and a shortened lifespan in mice. Sci Rep. 2026 May 28;16(1)
Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
Citing These Resources
Funding Information
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Send questions and comments to User Support. 		last database update
09/08/2026
MGI 6.24 		The Jackson Laboratory