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Mapk7 Gene Detail
Summary
  • Symbol
    Mapk7
  • Name
    mitogen-activated protein kinase 7
  • Synonyms
    b2b2346Clo, big MAP kinase 1, BMK1, ERK5, Erk5-T
  • Feature Type
    protein coding gene
  • IDs
    MGI:1346347
    NCBI Gene: 23939
  • Alliance
  • Transcription Start Sites
    3 TSS
Location &
Maps
more
  • Sequence Map
    Chr11:61379638-61385101 bp, - strand
    From NCBI annotation of GRCm39
  • View this region in JBrowse
  • Genome Browsers
  • Genetic Map
    Chromosome 11, 37.96 cM
  • Mapping Data
    2 experiments
Strain
Comparison
more
  • SNPs within 2kb
    20 from dbSNP Build 142
  • Strain Annotations
    18
For selected strains:
Strain Gene Model ID Feature Type Coordinates Select Strains
C57BL/6J MGI_C57BL6J_1346347
protein coding gene Chr11:61379638-61385232 (-)
129S1/SvImJ MGP_129S1SvImJ_G0018440
protein coding gene Chr11:61451279-61456887 (-)
A/J MGP_AJ_G0018409
protein coding gene Chr11:59183180-59188774 (-)
AKR/J MGP_AKRJ_G0018379
protein coding gene Chr11:61025300-61030908 (-)
BALB/cJ MGP_BALBcJ_G0018380
protein coding gene Chr11:59488845-59494439 (-)
C3H/HeJ MGP_C3HHeJ_G0018193
protein coding gene Chr11:61005220-61010814 (-)
C57BL/6NJ MGP_C57BL6NJ_G0018832
protein coding gene Chr11:63399870-63405464 (-)
CAROLI/EiJ MGP_CAROLIEiJ_G0016478
protein coding gene Chr11:56309252-56315011 (-)
CAST/EiJ MGP_CASTEiJ_G0017750
protein coding gene Chr11:61111731-61117324 (-)
CBA/J MGP_CBAJ_G0018167
protein coding gene Chr11:66149933-66155527 (-)
DBA/2J MGP_DBA2J_G0018276
protein coding gene Chr11:58757268-58762855 (-)
FVB/NJ MGP_FVBNJ_G0018267
protein coding gene Chr11:58442091-58447699 (-)
LP/J MGP_LPJ_G0018349
protein coding gene Chr11:62019651-62025259 (-)
NOD/ShiLtJ MGP_NODShiLtJ_G0018291
protein coding gene Chr11:67166125-67171733 (-)
NZO/HlLtJ MGP_NZOHlLtJ_G0018873
protein coding gene Chr11:61159709-61165317 (-)
PWK/PhJ MGP_PWKPhJ_G0017523
protein coding gene Chr11:59354947-59360569 (-)
SPRET/EiJ MGP_SPRETEiJ_G0017313
protein coding gene Chr11:60984395-60989941 (-)
WSB/EiJ MGP_WSBEiJ_G0017802
protein coding gene Chr11:60766778-60772386 (-)



Homology
more
  • Human Ortholog
    MAPK7, mitogen-activated protein kinase 7
  • Vertebrate Orthologs
    3
Vertebrate Orthology Source
Alliance of Genome Resources
  • Human Ortholog
    MAPK7, mitogen-activated protein kinase 7
  • Synonyms
    BMK1, ERK4, ERK5, PRKM7
  • Links
    NCBI Gene ID: 5598
    neXtProt AC: NX_Q13164
    UniProt: Q13164

  • Chr Location
    17p11.2; chr17:19377721-19383544 (+)  GRCh38

Mutations,
Alleles, and
Phenotypes
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  • Phenotype Summary
    59 phenotypes from 7 alleles in 7 genetic backgrounds
    27 images
    49 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
integument
immune system
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
neoplasm
vision/eye

Click cells to view annotations.
Homozygous inactivation of this gene leads to embryonic growth retardation and midgestational lethality due to multiple developmental anomalies and vascular remodelling, cardiac development, and placental defects.
Gene Ontology
(GO)
Classifications
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  • All GO Annotations
  • GO References
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
RNA binding
signaling receptor activity
signaling receptor binding
transcription
transferase
transporter
Biological Process

carbohydrate derivative metabolism
cell differentiation
cell population proliferation
cellular component organization
DNA-templated transcription
establishment of localization
homeostatic process
immune system process
lipid metabolic process
programmed cell death
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
non-membrane-bounded organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
protein-containing complex
synapse
vacuole
Click cells to view annotations.
Expression
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Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
  • Tissues
  • cDNA Data
  • Literature Summary
  • Comparison Matrix
  • Sequences &
    Gene Models
    less
    Representative SequencesLengthStrain/SpeciesFlank
    genomic 23939 NCBI Gene Model | MGI Sequence Detail 5464 C57BL/6J ±  kb
    transcript NM_001291035 RefSeq | MGI Sequence Detail 3265 C57BL/6  
    polypeptide Q9WVS8 UniProt | EBI | MGI Sequence Detail 806 Not Applicable  
    For the selected sequence
    Protein
    Information
    less
    Molecular
    Reagents
    less
    • All nucleic 80
      cDNA 77
      Primer pair 3

      Microarray probesets 3
    Other
    Accession IDs
    less
    MGI:5554536
    References
    more
    • Summaries
      All 121
      Developmental Gene Expression 15
      Gene Ontology 13
      Phenotypes 49
    • Earliest
      J:137335 Roderick TH, Chromosomal inversions in studies of mammalian mutagenesis. Genetics. 1979 May;92(1 Pt 1 Suppl):s121-6
    • Latest
      J:339061 Tsitsikov EN, et al., TRAF7 is an essential regulator of blood vessel integrity during mouse embryonic and neonatal development. iScience. 2023 Aug 18;26(8):107474

    Contributing Projects:
    Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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    last database update
    03/12/2024
    MGI 6.23
    The Jackson Laboratory