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Xcr1 Gene Detail
Summary
  • Symbol
    Xcr1
  • Name
    chemokine (C motif) receptor 1
  • Synonyms
    Ccxcr1, C motif-1/lymphotactin receptor, GPR5, XCR1
  • Feature Type
    protein coding gene
  • IDs
    MGI:1346338
    NCBI Gene: 23832
  • Alliance
    genome feature page
  • Transcription Start Sites
    2 TSS
Location &
Maps
more
  • Sequence Map
    Chr9:123681380-123691094 bp, - strand
    From NCBI annotation of GRCm39
  • View this region in JBrowse
  • Genome Browsers
    Ensembl | UCSC | NCBI
  • Genetic Map
    Chromosome 9, 74.71 cM, cytoband F4
  • Mapping Data
    3 experiments
Strain
Comparison
more
  • SNPs within 2kb
    499 from dbSNP Build 142
  • Strain Annotations
    19
For selected strains:
Strain Gene Model ID Feature Type Coordinates Select Strains
C57BL/6J MGI_C57BL6J_1346338
 protein coding gene Chr9:123681380-123691094 (-)
129S1/SvImJ ENSMUSG00200027077
 protein coding gene Chr9:120805629-120815253 (-)
A/J ENSMUSG00195025260
 protein coding gene Chr9:119955370-119965085 (-)
AKR/J ENSMUSG00220019392
 protein coding gene Chr9:120421747-120431462 (-)
BALB/cJ ENSMUSG00180024646
 protein coding gene Chr9:120495174-120504889 (-)
C3H/HeJ ENSMUSG00175016566
 protein coding gene Chr9:120731536-120741250 (-)
C57BL/6NJ ENSMUSG00215018454
 protein coding gene Chr9:120645308-120655025 (-)
CAROLI/EiJ MGP_CAROLIEiJ_G0032867
 protein coding gene Chr9:119166215-119173984 (-)
CAST/EiJ ENSTCUG00005016784
 protein coding gene Chr9:120311871-120321544 (-)
CBA/J ENSMUSG00210036699
 protein coding gene Chr9:120449864-120459579 (-)
DBA/2J ENSMUSG00185016373
 protein coding gene Chr9:120785579-120795293 (-)
FVB/NJ ENSMUSG00205016094
 protein coding gene Chr9:120617141-120626854 (-)
JF1/MsJ ENSUMUG00000046886
 protein coding gene Chr9:120565535-120575158 (-)
LP/J ENSMUSG00230036820
 protein coding gene Chr9:120945752-120955376 (-)
NOD/ShiLtJ ENSMUSG00190013998
 protein coding gene Chr9:120392723-120402437 (-)
NZO/HlLtJ ENSMUSG00225023172
 protein coding gene Chr9:121210544-121220258 (-)
PWK/PhJ ENSLUMG00010036320
 protein coding gene Chr9:120460991-120470639 (-)
SPRET/EiJ ENSMSPG00010000496
 protein coding gene Chr9:122229471-122235166 (-)
WSB/EiJ ENSIUOG00005021047
 protein coding gene Chr9:119817071-119826793 (-)



Homology
more
  • Human Ortholog
    XCR1, X-C motif chemokine receptor 1
  • Vertebrate Orthologs
    4
Vertebrate Orthology Source
Alliance of Genome Resources
  • Human Ortholog
    XCR1, X-C motif chemokine receptor 1
  • Synonyms
    CCXCR1, GPR5
  • Links
    NCBI Gene ID: 2829
    UniProt: P46094

  • Chr Location
    3p21.31; chr3:46016990-46085844 (-)  GRCh38
Mutations,
Alleles, and
Phenotypes
less
  • Phenotype Summary
    3 phenotypes from 2 alleles in 3 genetic backgrounds
    6 phenotypes from multigenic genotypes
    101 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
integument
immune system
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
neoplasm
vision/eye

Click cells to view annotations.
Mice homozygous for a targeted null mutation exhibit reduced CD8+ dendritic cell migration in response to XCL1.
Gene Ontology
(GO)
Classifications
less
  • All GO Annotations
    18
  • GO References
    5
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
RNA binding
signaling receptor activity
signaling receptor binding
transcription
transferase
transporter
Biological Process

carbohydrate derivative metabolism
cell differentiation
cell population proliferation
cellular component organization
DNA-templated transcription
establishment of localization
homeostatic process
immune system process
lipid metabolic process
programmed cell death
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
membraneless organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
protein-containing complex
synapse
vacuole
Click cells to view annotations.
Expression
less
Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
    746
  • Tissues
    94
  • cDNA Data
    7
  • Literature Summary
    3
Sequences &
Gene Models
less
Representative SequencesLengthStrain/SpeciesFlank
genomic 23832 NCBI Gene Model | MGI Sequence Detail 9715 C57BL/6J ±  kb
transcript NM_011798 RefSeq | MGI Sequence Detail 4454 C57BL/6  
polypeptide Q9R0M1 UniProt | EBI | MGI Sequence Detail 322 Not Applicable  
For the selected sequence
Protein
Information
less
Molecular
Reagents
less
  • All nucleic 8
    cDNA 7
    Primer pair 1

    Microarray probesets 3
References
more
  • Summaries
    All 129
    Developmental Gene Expression 3
    Gene Ontology 5
    Phenotypes 101
  • Earliest
    J:57566 Yoshida T, et al., Molecular cloning of mXCR1, the murine SCM-1/lymphotactin receptor. FEBS Lett. 1999 Sep 10;458(1):37-40
  • Latest
    J:390482 Hunt KS, et al., Reduced Tumor Control in Males Can Result from Impaired CD4+ T-cell Help through the CD40L-CD40 Pathway. Cancer Immunol Res. 2026 Jul 2;14(7):1068-1079
Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
Citing These Resources
Funding Information
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Send questions and comments to User Support. 		last database update
09/08/2026
MGI 6.24 		The Jackson Laboratory