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Uts2 Gene Detail
Summary
  • Symbol
    Uts2
  • Name
    urotensin 2
  • Synonyms
    prepro-UII, Ucn2, urotensin II precursor
  • Feature Type
    protein coding gene
  • IDs
    MGI:1346329
    NCBI Gene: 24111
  • Alliance
    gene page
  • Transcription Start Sites
    1 TSS
Location &
Maps
more
  • Sequence Map
    Chr4:151081554-151086267 bp, + strand
    From NCBI annotation of GRCm39
  • View this region in JBrowse
  • Genome Browsers
    Ensembl | UCSC | NCBI
  • Genetic Map
    Chromosome 4, 81.53 cM, cytoband E1
  • Mapping Data
    1 experiment
Strain
Comparison
more
  • SNPs within 2kb
    120 from dbSNP Build 142
  • Strain Annotations
    18
For selected strains:
Strain Gene Model ID Feature Type Coordinates Select Strains
C57BL/6J MGI_C57BL6J_1346329
 protein coding gene Chr4:151081554-151086267 (+)
129S1/SvImJ MGP_129S1SvImJ_G0029160
 protein coding gene Chr4:155026220-155031032 (+)
A/J MGP_AJ_G0029125
 protein coding gene Chr4:148507442-148512155 (+)
AKR/J MGP_AKRJ_G0029073
 protein coding gene Chr4:152576122-152580848 (+)
BALB/cJ MGP_BALBcJ_G0029141
 protein coding gene Chr4:149001592-149006305 (+)
C3H/HeJ MGP_C3HHeJ_G0028862
 protein coding gene Chr4:153144781-153149498 (+)
C57BL/6NJ MGP_C57BL6NJ_G0029590
 protein coding gene Chr4:160594922-160599635 (+)
CAROLI/EiJ MGP_CAROLIEiJ_G0026836
 protein coding gene Chr4:140888567-140893255 (+)
CAST/EiJ MGP_CASTEiJ_G0028275
 protein coding gene Chr4:150423027-150427758 (+)
CBA/J MGP_CBAJ_G0028824
 protein coding gene Chr4:165360367-165365789 (+)
DBA/2J MGP_DBA2J_G0028973
 protein coding gene Chr4:148584722-148589440 (+)
FVB/NJ MGP_FVBNJ_G0028937
 protein coding gene Chr4:147727559-147733107 (+)
LP/J MGP_LPJ_G0029063
 protein coding gene Chr4:154959367-154964073 (+)
NOD/ShiLtJ MGP_NODShiLtJ_G0028964
 protein coding gene Chr4:168476781-168482617 (+)
NZO/HlLtJ MGP_NZOHlLtJ_G0029622
 protein coding gene Chr4:153102503-153108251 (+)
PWK/PhJ MGP_PWKPhJ_G0027995
 protein coding gene Chr4:144620840-144625532 (+)
SPRET/EiJ MGP_SPRETEiJ_G0027829
 protein coding gene Chr4:147351558-147356231 (+)
WSB/EiJ MGP_WSBEiJ_G0028355
 protein coding gene Chr4:153235269-153239984 (+)



Homology
more
  • Human Ortholog
    UTS2, urotensin 2
  • Vertebrate Orthologs
    4
Vertebrate Orthology Source
Alliance of Genome Resources
  • Human Ortholog
    UTS2, urotensin 2
  • Synonyms
    PRO1068, UCN2, UII, U-II
  • Links
    NCBI Gene ID: 10911
    neXtProt AC: NX_O95399
    UniProt: O95399

  • Chr Location
    1p36.23; chr1:7843083-7913249 (-)  GRCh38
Human Diseases
more
  • Diseases
    2 with human UTS2 associations

Human Disease Mouse Models
      
IDs
IDs
Click on a disease name to see all genes associated with that disease.

Mutations,
Alleles, and
Phenotypes
less
  • Phenotype Summary
    6 phenotypes from 1 allele in 1 genetic background
    13 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
integument
immune system
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
neoplasm
vision/eye

Click cells to view annotations.
Homozygous inactivation of this gene leads to alterations in macrophage and hepatic cholesterol homeostasis.
Gene Ontology
(GO)
Classifications
less
  • All GO Annotations
    25
  • GO References
    5
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
RNA binding
signaling receptor activity
signaling receptor binding
transcription
transferase
transporter
Biological Process

carbohydrate derivative metabolism
cell differentiation
cell population proliferation
cellular component organization
DNA-templated transcription
establishment of localization
homeostatic process
immune system process
lipid metabolic process
programmed cell death
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
non-membrane-bounded organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
protein-containing complex
synapse
vacuole
Click cells to view annotations.
Expression
less
Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
    879
  • Tissues
    36
  • cDNA Data
    4
  • Literature Summary
    1
  • Comparison Matrix
    Gene Expression + Phenotype
    • Sequences &
    Gene Models
    less
    Representative SequencesLengthStrain/SpeciesFlank
    genomic 24111 NCBI Gene Model | MGI Sequence Detail 4714 C57BL/6J ±  kb
    transcript NM_011910 RefSeq | MGI Sequence Detail 538 C57BL/6  
    polypeptide Q9QZQ3 UniProt | EBI | MGI Sequence Detail 123 Not Applicable  
    For the selected sequence
    Protein
    Information
    less
    Molecular
    Reagents
    less
    • All nucleic 4
      cDNA 4

      Microarray probesets 2
    References
    more
    • Summaries
      All 39
      Developmental Gene Expression 1
      Gene Ontology 5
      Phenotypes 13
    • Earliest
      J:57017 Coulouarn Y, et al., Cloning, sequence analysis and tissue distribution of the mouse and rat urotensin II precursors. FEBS Lett. 1999 Aug 20;457(1):28-32
    • Latest
      J:326541 Cyagen Biosciences Inc., Cyagen Biosciences Website. 2022;
    Contributing Projects:
    Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
    Citing These Resources
    Funding Information
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    Send questions and comments to User Support.     		last database update
    04/09/2024
    MGI 6.23     		The Jackson Laboratory