About   Help   FAQ
Sh3yl1 Gene Detail
Summary
  • Symbol
    Sh3yl1
  • Name
    Sh3 domain YSC-like 1
  • Synonyms
    Ray, YSC84
  • Feature Type
    protein coding gene
  • IDs
    MGI:1346118
    NCBI Gene: 24057
  • Alliance
    gene page
  • Transcription Start Sites
    6 TSS
Location &
Maps
more
  • Sequence Map
    Chr12:30961667-31010161 bp, + strand
    From Ensembl annotation of GRCm39
  • View this region in JBrowse
  • Genome Browsers
    Ensembl | UCSC | NCBI
  • Genetic Map
    Chromosome 12, 13.01 cM
  • Mapping Data
    1 experiment
Strain
Comparison
more
  • SNPs within 2kb
    197 from dbSNP Build 142
  • Strain Annotations
    18
For selected strains:
Strain Gene Model ID Feature Type Coordinates Select Strains
C57BL/6J MGI_C57BL6J_1346118
 protein coding gene Chr12:30961622-31010161 (+)
129S1/SvImJ MGP_129S1SvImJ_G0019655
 protein coding gene Chr12:28834060-28887078 (+)
A/J MGP_AJ_G0019622
 protein coding gene Chr12:28024657-28074883 (+)
AKR/J MGP_AKRJ_G0019593
 protein coding gene Chr12:28927658-28977830 (+)
BALB/cJ MGP_BALBcJ_G0019599
 protein coding gene Chr12:28270039-28317794 (+)
C3H/HeJ MGP_C3HHeJ_G0019403
 protein coding gene Chr12:28793563-28845250 (+)
C57BL/6NJ MGP_C57BL6NJ_G0020046
 protein coding gene Chr12:29727024-29779582 (+)
CAROLI/EiJ MGP_CAROLIEiJ_G0017671
 protein coding gene Chr12:27345381-27389627 (+)
CAST/EiJ MGP_CASTEiJ_G0018958
 protein coding gene Chr12:23791597-23851017 (+)
CBA/J MGP_CBAJ_G0019374
 protein coding gene Chr12:30701804-30760225 (+)
DBA/2J MGP_DBA2J_G0019488
 protein coding gene Chr12:27865399-27914956 (+)
FVB/NJ MGP_FVBNJ_G0019479
 protein coding gene Chr12:27659191-27709083 (+)
LP/J MGP_LPJ_G0019558
 protein coding gene Chr12:28932600-28982340 (+)
NOD/ShiLtJ MGP_NODShiLtJ_G0019514
 protein coding gene Chr12:30325907-30384734 (+)
NZO/HlLtJ MGP_NZOHlLtJ_G0020086
 protein coding gene Chr12:28447663-28498299 (+)
PWK/PhJ MGP_PWKPhJ_G0018725
 protein coding gene Chr12:22598435-22654350 (+)
SPRET/EiJ MGP_SPRETEiJ_G0018513
 protein coding gene Chr12:23068768-23118927 (+)
WSB/EiJ MGP_WSBEiJ_G0019008
 protein coding gene Chr12:28688231-28738820 (+)



Homology
more
  • Human Ortholog
    SH3YL1, SH3 and SYLF domain containing 1
  • Vertebrate Orthologs
    3
Vertebrate Orthology Source
Alliance of Genome Resources
  • Human Ortholog
    SH3YL1, SH3 and SYLF domain containing 1
  • Synonyms
    RAY
  • Links
    NCBI Gene ID: 26751
    neXtProt AC: NX_Q96HL8
    UniProt: Q96HL8

  • Chr Location
    2p25.3; chr2:217730-266398 (-)  GRCh38
Mutations,
Alleles, and
Phenotypes
less
  • Phenotype Summary
    8 phenotypes from 1 allele in 1 genetic background
    4 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
integument
immune system
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
neoplasm
vision/eye

Click cells to view annotations.
Homozygous knockout suppresses inflammatory reactions and reduces susceptibility to LPS-induced acute kidney disease.
Gene Ontology
(GO)
Classifications
less
  • All GO Annotations
    12
  • GO References
    5
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
RNA binding
signaling receptor activity
signaling receptor binding
transcription
transferase
transporter
Biological Process

carbohydrate derivative metabolism
cell differentiation
cell population proliferation
cellular component organization
DNA-templated transcription
establishment of localization
homeostatic process
immune system process
lipid metabolic process
programmed cell death
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
non-membrane-bounded organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
protein-containing complex
synapse
vacuole
Click cells to view annotations.
Expression
less
Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
    706
  • cDNA Data
    43
  • Comparison Matrix
    Gene Expression + Phenotype
    • Sequences &
    Gene Models
    less
    Representative SequencesLengthStrain/SpeciesFlank
    genomic ENSMUSG00000020669 Ensembl Gene Model | MGI Sequence Detail 48495 C57BL/6J ±  kb
    transcript ENSMUST00000020997 Ensembl | MGI Sequence Detail 1750 Not Applicable  
    polypeptide ENSMUSP00000020997 Ensembl | MGI Sequence Detail 340 Not Applicable  
    For the selected sequence
    Protein
    Information
    less
    Molecular
    Reagents
    less
    • All nucleic 43
      cDNA 43

      Microarray probesets 3
    Other
    Accession IDs
    less
    MGI:2144784
    References
    more
    • Summaries
      All 27
      Gene Ontology 5
      Phenotypes 4
    • Earliest
      J:62054 Aoki N, et al., A novel mouse gene, Sh3yl1, is expressed in the anagen hair follicle. J Invest Dermatol. 2000 May;114(5):1050-6
    • Latest
      J:298830 Yoo JY, et al., LPS-Induced Acute Kidney Injury Is Mediated by Nox4-SH3YL1. Cell Rep. 2020 Oct 20;33(3):108245
    Contributing Projects:
    Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
    Citing These Resources
    Funding Information
    Warranty Disclaimer, Privacy Notice, Licensing, & Copyright
    Send questions and comments to User Support.     		last database update
    04/16/2024
    MGI 6.23     		The Jackson Laboratory