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Trib3 Gene Detail
Summary
  • Symbol
    Trib3
  • Name
    tribbles pseudokinase 3
  • Synonyms
    Ifld2, Nipk, SKIP3, Trb3
  • Feature Type
    protein coding gene
  • IDs
    MGI:1345675
    NCBI Gene: 228775
  • Alliance
    genome feature page
  • Transcription Start Sites
    7 TSS
Location &
Maps
more
  • Sequence Map
    Chr2:152179342-152185952 bp, - strand
    From Ensembl annotation of GRCm39
  • View this region in JBrowse
  • Genome Browsers
    Ensembl | UCSC | NCBI
  • Genetic Map
    Chromosome 2, 74.83 cM
  • Mapping Data
    3 experiments
Strain
Comparison
more
  • SNPs within 2kb
    228 from dbSNP Build 142
  • Strain Annotations
    19
  • RFLP
    1
For selected strains:
Strain Gene Model ID Feature Type Coordinates Select Strains
C57BL/6J MGI_C57BL6J_1345675
 protein coding gene Chr2:152179342-152185980 (-)
129S1/SvImJ ENSMUSG00200029177
 protein coding gene Chr2:149081173-149087700 (-)
A/J ENSMUSG00195017069
 protein coding gene Chr2:149364283-149370897 (-)
AKR/J ENSMUSG00220044920
 protein coding gene Chr2:148687798-148694412 (-)
BALB/cJ ENSMUSG00180038362
 protein coding gene Chr2:148849326-148855940 (-)
C3H/HeJ ENSMUSG00175039465
 protein coding gene Chr2:149595542-149602154 (-)
C57BL/6NJ ENSMUSG00215019785
 protein coding gene Chr2:149022496-149029106 (-)
CAROLI/EiJ MGP_CAROLIEiJ_G0024451
 protein coding gene Chr2:144214090-144221082 (-)
CAST/EiJ ENSTCUG00005039931
 protein coding gene Chr2:147940627-147947236 (-)
CBA/J ENSMUSG00210042969
 protein coding gene Chr2:149532056-149538667 (-)
DBA/2J ENSMUSG00185045518
 protein coding gene Chr2:149182517-149189129 (-)
FVB/NJ ENSMUSG00205024626
 protein coding gene Chr2:148279261-148285875 (-)
JF1/MsJ ENSUMUG00000045655
 protein coding gene Chr2:148853726-148860322 (-)
LP/J ENSMUSG00230032026
 protein coding gene Chr2:150833594-150840119 (-)
NOD/ShiLtJ ENSMUSG00190034520
 protein coding gene Chr2:148953162-148959764 (-)
NZO/HlLtJ ENSMUSG00225004361
 protein coding gene Chr2:158870665-158877279 (-)
PWK/PhJ ENSLUMG00010037786
 protein coding gene Chr2:148823040-148829863 (-)
SPRET/EiJ ENSMSPG00010028344
 protein coding gene Chr2:151549377-151555468 (-)
WSB/EiJ ENSIUOG00005046672
 protein coding gene Chr2:148688520-148695111 (-)



Homology
more
  • Human Ortholog
    TRIB3, tribbles pseudokinase 3
  • Vertebrate Orthologs
    3
Vertebrate Orthology Source
Alliance of Genome Resources
  • Human Ortholog
    TRIB3, tribbles pseudokinase 3
  • Synonyms
    C20orf97, NIPK, SINK, SKIP3, TRB3
  • Links
    NCBI Gene ID: 57761
    UniProt: Q96RU7

  • Chr Location
    20p13; chr20:362835-397564 (+)  GRCh38
Mutations,
Alleles, and
Phenotypes
less
  • Phenotype Summary
    9 phenotypes from 4 alleles in 3 genetic backgrounds
    35 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
integument
immune system
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
neoplasm
vision/eye

Click cells to view annotations.
Homozygous null mutants may display hypoactivity, decreased blood pressure and abnormal digit morphology or abnormal mast cell physiology.
Gene Ontology
(GO)
Classifications
less
  • All GO Annotations
    58
  • GO References
    14
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
RNA binding
signaling receptor activity
signaling receptor binding
transcription
transferase
transporter
Biological Process

carbohydrate derivative metabolism
cell differentiation
cell population proliferation
cellular component organization
DNA-templated transcription
establishment of localization
homeostatic process
immune system process
lipid metabolic process
programmed cell death
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
membraneless organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
protein-containing complex
synapse
vacuole
Click cells to view annotations.
Expression
less
Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
    690
  • Tissues
    66
  • cDNA Data
    43
  • Literature Summary
    26
  • Comparison Matrix
    Gene Expression + Phenotype
    • Sequences &
    Gene Models
    less
    Representative SequencesLengthStrain/SpeciesFlank
    genomic ENSMUSG00000032715 Ensembl Gene Model | MGI Sequence Detail 6611 C57BL/6J ±  kb
    transcript ENSMUST00000040312 Ensembl | MGI Sequence Detail 2026 Not Applicable  
    polypeptide ENSMUSP00000041747 Ensembl | MGI Sequence Detail 354 Not Applicable  
    For the selected sequence
    Protein
    Information
    less
    Molecular
    Reagents
    less
    • All nucleic 50
      cDNA 43
      Primer pair 7

      Microarray probesets 3
    References
    more
    • Summaries
      All 115
      Developmental Gene Expression 26
      Gene Ontology 14
      Phenotypes 35
    • Earliest
      J:109968 Roderick TH, et al., Nineteen paracentric chromosomal inversions in mice. Genetics. 1974 Jan;76(1):109-17
    • Latest
      J:391329 Duan CH, et al., Loss of Echs1 in neural stem and progenitor cells impairs neurogenesis via ER stress activation and lipid metabolic reprogramming. Nat Commun. 2026 Jul 1;17(1)
    Contributing Projects:
    Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
    Citing These Resources
    Funding Information
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    Send questions and comments to User Support.     		last database update
    09/08/2026
    MGI 6.24     		The Jackson Laboratory