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Tenm3 Gene Detail
Summary
  • Symbol
    Tenm3
  • Name
    teneurin transmembrane protein 3
  • Synonyms
    2610100B16Rik, mKIAA1455, Odz3, Ten-m3
  • Feature Type
    protein coding gene
  • IDs
    MGI:1345183
    NCBI Gene: 23965
  • Alliance
    genome feature page
  • Transcription Start Sites
    15 TSS
  • Regulated by
    Rr695532 (1 regulatory region)
Location &
Maps
more
  • Sequence Map
    Chr8:48680717-49296986 bp, - strand
    From Ensembl annotation of GRCm39
  • View this region in JBrowse
  • Genome Browsers
    Ensembl | UCSC | NCBI
  • Genetic Map
    Chromosome 8, 27.02 cM, cytoband B2
  • Mapping Data
    2 experiments
Strain
Comparison
more
  • SNPs within 2kb
    16900 from dbSNP Build 142
  • Strain Annotations
    27
For selected strains:
Strain Gene Model ID Feature Type Coordinates Select Strains
C57BL/6J MGI_C57BL6J_1345183
 protein coding gene Chr8:48678700-51370255 (-)
129S1/SvImJ ENSMUSG00200005456
 protein coding gene Chr8:43871900-44091818 (-)
129S1/SvImJ ENSMUSGG00200054626
 protein coding gene Chr8:44182798-44211305 (-)
A/J ENSMUSG00195003988
 protein coding gene Chr8:44406851-44627035 (-)
A/J ENSMUSGG00195055268
 protein coding gene Chr8:44718069-44746533 (-)
AKR/J ENSMUSG00220003812
 protein coding gene Chr8:44196421-44416614 (-)
AKR/J ENSMUSGG00220054713
 protein coding gene Chr8:44507629-44536088 (-)
BALB/cJ ENSMUSGG00180055356
 protein coding gene Chr8:44265353-44293809 (-)
BALB/cJ ENSMUSG00180002872
 protein coding gene Chr8:43954148-44174335 (-)
C3H/HeJ ENSMUSG00175004974
 protein coding gene Chr8:44069304-44289421 (-)
C3H/HeJ ENSMUSGG00175054743
 protein coding gene Chr8:44380425-44408880 (-)
C57BL/6NJ ENSMUSGG00215055671
 protein coding gene Chr8:44190089-44218551 (-)
C57BL/6NJ ENSMUSG00215008631
 protein coding gene Chr8:43878910-44099076 (-)
CAROLI/EiJ MGP_CAROLIEiJ_G0031049
 protein coding gene Chr8:41813734-42441184 (-)
CAST/EiJ no annotation
CBA/J ENSMUSG00210018627
 protein coding gene Chr8:43942676-44169303 (-)
CBA/J ENSMUSGG00210054886
 protein coding gene Chr8:44260272-44288765 (-)
DBA/2J ENSMUSG00185005574
 protein coding gene Chr8:49833302-50053410 (-)
DBA/2J ENSMUSGG00185057692
 protein coding gene Chr8:50144415-50172867 (-)
FVB/NJ ENSMUSGG00205054549
 protein coding gene Chr8:43383361-43411860 (-)
FVB/NJ ENSMUSG00205002632
 protein coding gene Chr8:43072435-43292366 (-)
JF1/MsJ no annotation
LP/J ENSMUSGG00230055695
 protein coding gene Chr8:53798996-53827501 (-)
LP/J ENSMUSG00230016633
 protein coding gene Chr8:53481399-53708015 (-)
NOD/ShiLtJ ENSMUSGG00190054874
 protein coding gene Chr8:44296047-44324503 (-)
NOD/ShiLtJ ENSMUSG00190005560
 protein coding gene Chr8:43984879-44205037 (-)
NZO/HlLtJ ENSMUSGG00225055485
 protein coding gene Chr8:57387088-57415509 (-)
NZO/HlLtJ ENSMUSG00225011514
 protein coding gene Chr8:57069314-57289302 (-)
PWK/PhJ no annotation
SPRET/EiJ ENSMSPG00010005783
 protein coding gene Chr8:44487786-44930865 (-)
WSB/EiJ no annotation



Homology
more
  • Human Ortholog
    TENM3, teneurin transmembrane protein 3
  • Vertebrate Orthologs
    4
Vertebrate Orthology Source
Alliance of Genome Resources
  • Human Ortholog
    TENM3, teneurin transmembrane protein 3
  • Synonyms
    MCOPCB9, MCOPS15, ODZ3, ten-3, TEN3, Ten-m3, TNM3
  • Links
    NCBI Gene ID: 55714
    UniProt: Q9P273

  • Chr Location
    4q34.3-q35.1; chr4:181447613-182803024 (+)  GRCh38
Human Diseases
more
  • Diseases
    1 with human TENM3 associations

Human Disease Mouse Models
      
IDs
Click on a disease name to see all genes associated with that disease.

Mutations,
Alleles, and
Phenotypes
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  • Phenotype Summary
    6 phenotypes from 2 alleles in 2 genetic backgrounds
    29 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
integument
immune system
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
neoplasm
vision/eye

Click cells to view annotations.
Mice homozygous for a null mutation display abnormal ipsilateral retinal ganglion cell projections and impaired performance in visually mediated behavioral tasks. A heterozygous p.Q2665P mutation conditionally expressed in embryonic limb buds leads to delayed chondrogenesis in left hip and shoulder joints.
Gene Ontology
(GO)
Classifications
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  • All GO Annotations
    29
  • GO References
    12
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
RNA binding
signaling receptor activity
signaling receptor binding
transcription
transferase
transporter
Biological Process

carbohydrate derivative metabolism
cell differentiation
cell population proliferation
cellular component organization
DNA-templated transcription
establishment of localization
homeostatic process
immune system process
lipid metabolic process
programmed cell death
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
membraneless organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
protein-containing complex
synapse
vacuole
Click cells to view annotations.
Expression
less
Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
    1021
  • Tissues
    271
  • cDNA Data
    11
  • Literature Summary
    31
  • Comparison Matrix
    Gene Expression + Phenotype
    • Sequences &
    Gene Models
    less
    Representative SequencesLengthStrain/SpeciesFlank
    genomic ENSMUSG00000031561 Ensembl Gene Model | MGI Sequence Detail 616270 C57BL/6J ±  kb
    transcript ENSMUST00000033965 Ensembl | MGI Sequence Detail 8961 Not Applicable  
    polypeptide ENSMUSP00000033965 Ensembl | MGI Sequence Detail 2715 Not Applicable  
    For the selected sequence
    Protein
    Information
    less
    Molecular
    Reagents
    less
    • All nucleic 26
      cDNA 14
      Primer pair 6
      Other 6
      Antibodies 3

      Microarray probesets 4
    Other
    Accession IDs
    less
    MGI:1917577
    References
    more
    • Summaries
      All 88
      Developmental Gene Expression 31
      Gene Ontology 12
      Phenotypes 29
    • Earliest
      J:30814 Neophytou PI, et al., A subtractive cloning approach to the identification of mRNAs specifically expressed in pancreatic beta-cells. Diabetes. 1996 Feb;45(2):127-33
    • Latest
      J:385967 Chon U, et al., Inverse expression of Ten3 and Lphn2 across the developing mouse brain suggests a global strategy for circuit assembly. Curr Biol. 2026 May 8;
    Contributing Projects:
    Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
    Citing These Resources
    Funding Information
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    Send questions and comments to User Support.     		last database update
    09/01/2026
    MGI 6.24     		The Jackson Laboratory