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Sra1 Gene Detail
Summary
  • Symbol
    Sra1
  • Name
    steroid receptor RNA activator 1
  • Synonyms
    Srap
  • Feature Type
    protein coding gene
  • IDs
    MGI:1344414
    NCBI Gene: 24068
  • Alliance
    gene page
  • Transcription Start Sites
    1 TSS
Location &
Maps
more
  • Sequence Map
    Chr18:36800240-36803364 bp, - strand
    From NCBI annotation of GRCm39
  • View this region in JBrowse
  • Genome Browsers
    Ensembl | UCSC | NCBI
  • Genetic Map
    Chromosome 18, 19.46 cM
  • Mapping Data
    2 experiments
Strain
Comparison
more
  • SNPs within 2kb
    29 from dbSNP Build 142
  • Strain Annotations
    18
For selected strains:
Strain Gene Model ID Feature Type Coordinates Select Strains
C57BL/6J MGI_C57BL6J_1344414
 protein coding gene Chr18:36799734-36803868 (-)
129S1/SvImJ MGP_129S1SvImJ_G0024282
 protein coding gene Chr18:35075013-35086268 (-)
A/J MGP_AJ_G0024248
 protein coding gene Chr18:33837331-33849787 (-)
AKR/J MGP_AKRJ_G0024216
 protein coding gene Chr18:34784954-34796233 (-)
BALB/cJ MGP_BALBcJ_G0024248
 protein coding gene Chr18:33889688-33902470 (-)
C3H/HeJ MGP_C3HHeJ_G0024015
 protein coding gene Chr18:34850354-34862681 (-)
C57BL/6NJ MGP_C57BL6NJ_G0024689
 protein coding gene Chr18:36304820-36317594 (-)
CAROLI/EiJ MGP_CAROLIEiJ_G0022129
 protein coding gene Chr18:33931880-33942512 (-)
CAST/EiJ MGP_CASTEiJ_G0023490
 protein coding gene Chr18:34860753-34876575 (-)
CBA/J MGP_CBAJ_G0023983
 protein coding gene Chr18:37380140-37392580 (-)
DBA/2J MGP_DBA2J_G0024115
 protein coding gene Chr18:33460362-33471687 (-)
FVB/NJ MGP_FVBNJ_G0024082
 protein coding gene Chr18:33166956-33178204 (-)
LP/J MGP_LPJ_G0024197
 protein coding gene Chr18:35103985-35116957 (-)
NOD/ShiLtJ MGP_NODShiLtJ_G0024110
 protein coding gene Chr18:38595144-38610125 (-)
NZO/HlLtJ MGP_NZOHlLtJ_G0024738
 protein coding gene Chr18:34658652-34669884 (-)
PWK/PhJ MGP_PWKPhJ_G0023234
 protein coding gene Chr18:33713304-33725133 (-)
SPRET/EiJ MGP_SPRETEiJ_G0023041
 protein coding gene Chr18:34903884-34915257 (-)
WSB/EiJ MGP_WSBEiJ_G0023553
 protein coding gene Chr18:34579104-34590341 (-)



Homology
more
  • Human Ortholog
    SRA1, steroid receptor RNA activator 1
  • Vertebrate Orthologs
    3
Vertebrate Orthology Source
Alliance of Genome Resources
  • Human Ortholog
    SRA1, steroid receptor RNA activator 1
  • Synonyms
    pp7684, SRA, SRAP, STRAA1
  • Links
    NCBI Gene ID: 10011
    neXtProt AC: NX_Q9HD15
    UniProt: Q9HD15

  • Chr Location
    5q31.3; chr5:140537340-140558093 (-)  GRCh38
Mutations,
Alleles, and
Phenotypes
less
  • Phenotype Summary
    24 phenotypes from 2 alleles in 2 genetic backgrounds
    10 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
integument
immune system
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
neoplasm
vision/eye

Click cells to view annotations.
Homozygous null mice are protected against diet-induced obesity.
Gene Ontology
(GO)
Classifications
less
  • All GO Annotations
    40
  • GO References
    10
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
RNA binding
signaling receptor activity
signaling receptor binding
transcription
transferase
transporter
Biological Process

carbohydrate derivative metabolism
cell differentiation
cell population proliferation
cellular component organization
DNA-templated transcription
establishment of localization
homeostatic process
immune system process
lipid metabolic process
programmed cell death
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
non-membrane-bounded organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
protein-containing complex
synapse
vacuole
Click cells to view annotations.
Expression
less
Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
    750
  • Tissues
    44
  • cDNA Data
    110
  • Literature Summary
    2
  • Comparison Matrix
    Gene Expression + Phenotype
    • Sequences &
    Gene Models
    less
    Representative SequencesLengthStrain/SpeciesFlank
    genomic 24068 NCBI Gene Model | MGI Sequence Detail 3125 C57BL/6J ±  kb
    transcript NR_028355 RefSeq | MGI Sequence Detail 1097 C57BL/6  
    polypeptide Q80VJ2 UniProt | EBI | MGI Sequence Detail 220 Not Applicable  
    For the selected sequence
    Protein
    Information
    less
    Molecular
    Reagents
    less
    • All nucleic 110
      cDNA 110

      Microarray probesets 2
    Other
    Accession IDs
    less
    MGI:2147187
    References
    more
    • Summaries
      All 44
      Developmental Gene Expression 2
      Gene Ontology 10
      Phenotypes 10
    • Earliest
      J:54002 Lanz RB, et al., A steroid receptor coactivator, SRA, functions as an RNA and is present in an SRC-1 complex. Cell. 1999 Apr 2;97(1):17-27
    • Latest
      J:307868 Mohammed Y, et al., Proteotyping of knockout mouse strains reveals sex- and strain-specific signatures in blood plasma. NPJ Syst Biol Appl. 2021 May 28;7(1):25
    Contributing Projects:
    Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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    Funding Information
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    Send questions and comments to User Support.     		last database update
    04/16/2024
    MGI 6.23     		The Jackson Laboratory