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Ubd Gene Detail
Summary
  • Symbol
    Ubd
  • Name
    ubiquitin D
  • Synonyms
    Diubiquitin, FAT10
  • Feature Type
    protein coding gene
  • IDs
    MGI:1344410
    NCBI Gene: 24108
  • Alliance
    genome feature page
  • Transcription Start Sites
    5 TSS
Location &
Maps
more
  • Sequence Map
    Chr17:37504783-37506986 bp, + strand
    From Ensembl annotation of GRCm39
  • View this region in JBrowse
  • Genome Browsers
    Ensembl | UCSC | NCBI
  • Genetic Map
    Chromosome 17, 19.16 cM, cytoband B3
  • Mapping Data
    2 experiments
Strain
Comparison
more
  • Strain Annotations
    19
For selected strains:
Strain Gene Model ID Feature Type Coordinates Select Strains
C57BL/6J MGI_C57BL6J_1344410
 protein coding gene Chr17:37504783-37506992 (+)
129S1/SvImJ ENSMUSG00200047933
 protein coding gene Chr17:32957759-32959962 (+)
A/J ENSMUSG00195038934
 protein coding gene Chr17:34169294-34171497 (+)
AKR/J ENSMUSG00220037199
 protein coding gene Chr17:32904286-32906489 (+)
BALB/cJ ENSMUSG00180029655
 protein coding gene Chr17:33650583-33652786 (+)
C3H/HeJ ENSMUSG00175039344
 protein coding gene Chr17:32844775-32846978 (+)
C57BL/6NJ ENSMUSG00215046465
 protein coding gene Chr17:32803145-32805348 (+)
CAROLI/EiJ MGP_CAROLIEiJ_G0021571
 protein coding gene Chr17:34187314-34189622 (+)
CAST/EiJ ENSTCUG00005050783
 protein coding gene Chr17:34037193-34039396 (+)
CBA/J ENSMUSG00210043836
 protein coding gene Chr17:32580987-32583190 (+)
DBA/2J ENSMUSG00185045334
 protein coding gene Chr17:35631484-35633687 (+)
FVB/NJ ENSMUSG00205021038
 protein coding gene Chr17:33159733-33161936 (+)
JF1/MsJ ENSUMUG00000017502
 protein coding gene Chr17:34579128-34581338 (+)
LP/J ENSMUSG00230054425
 protein coding gene Chr17:36752574-36754777 (+)
NOD/ShiLtJ ENSMUSG00190026670
 protein coding gene Chr17:32844488-32846691 (+)
NZO/HlLtJ ENSMUSG00225051952
 protein coding gene Chr17:38712307-38714510 (+)
PWK/PhJ ENSLUMG00010033747
 protein coding gene Chr17:32465469-32467672 (+)
SPRET/EiJ ENSMSPG00010036448
 protein coding gene Chr17:33749866-33752067 (+)
WSB/EiJ ENSIUOG00005048417
 protein coding gene Chr17:33669349-33671552 (+)



Homology
more
  • Human Ortholog
    UBD, ubiquitin like modifier D
  • Vertebrate Orthologs
    2
Vertebrate Orthology Source
Alliance of Genome Resources
  • Human Ortholog
    UBD, ubiquitin like modifier D
  • Synonyms
    FAT10, UBD-3
  • Links
    NCBI Gene ID: 10537
    UniProt: O15205

  • Chr Location
    6p22.1; chr6:29555515-29559732 (-)  GRCh38
Mutations,
Alleles, and
Phenotypes
less
  • Phenotype Summary
    8 phenotypes from 2 alleles in 2 genetic backgrounds
    17 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
integument
immune system
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
neoplasm
vision/eye

Click cells to view annotations.
Mice hompzygous for disruptions in this gene show an increased susceptibility to low doses of endotoxin and increased apoptosis among lymphocytes but are otherwise normal.
Gene Ontology
(GO)
Classifications
less
  • All GO Annotations
    54
  • GO References
    11
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
RNA binding
signaling receptor activity
signaling receptor binding
transcription
transferase
transporter
Biological Process

carbohydrate derivative metabolism
cell differentiation
cell population proliferation
cellular component organization
DNA-templated transcription
establishment of localization
homeostatic process
immune system process
lipid metabolic process
programmed cell death
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
membraneless organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
protein-containing complex
synapse
vacuole
Click cells to view annotations.
Expression
less
Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
    714
  • Tissues
    63
  • cDNA Data
    16
  • Literature Summary
    3
  • Comparison Matrix
    Gene Expression + Phenotype
    • Sequences &
    Gene Models
    less
    Representative SequencesLengthStrain/SpeciesFlank
    genomic ENSMUSG00000035186 Ensembl Gene Model | MGI Sequence Detail 2204 C57BL/6J ±  kb
    transcript ENSMUST00000038844 Ensembl | MGI Sequence Detail 931 Not Applicable  
    polypeptide ENSMUSP00000035808 Ensembl | MGI Sequence Detail 162 Not Applicable  
    For the selected sequence
    Protein
    Information
    less
    Molecular
    Reagents
    less
    • All nucleic 16
      cDNA 16

      Microarray probesets 4
    References
    more
    • Summaries
      All 57
      Developmental Gene Expression 3
      Gene Ontology 11
      Phenotypes 17
    • Earliest
      J:54530 Liu YC, et al., A MHC-encoded ubiquitin-like protein (FAT10) binds noncovalently to the spindle assembly checkpoint protein MAD2. Proc Natl Acad Sci U S A. 1999 Apr 13;96(8):4313-8
    • Latest
      J:345621 Adams DJ, et al., Genetic determinants of micronucleus formation in vivo. Nature. 2024 Mar;627(8002):130-136
    Contributing Projects:
    Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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    Funding Information
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    Send questions and comments to User Support.     		last database update
    09/01/2026
    MGI 6.24     		The Jackson Laboratory