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Arih2 Gene Detail
Summary
  • Symbol
    Arih2
  • Name
    ariadne RBR E3 ubiquitin protein ligase 2
  • Synonyms
    TRIAD1
  • Feature Type
    protein coding gene
  • IDs
    MGI:1344361
    NCBI Gene: 23807
  • Alliance
    genome feature page
  • Transcription Start Sites
    10 TSS
Location &
Maps
more
  • Sequence Map
    Chr9:108480141-108526585 bp, - strand
    From Ensembl annotation of GRCm39
  • View this region in JBrowse
  • Genome Browsers
    Ensembl | UCSC | NCBI
  • Genetic Map
    Chromosome 9, 59.54 cM
  • Mapping Data
    2 experiments
Strain
Comparison
more
  • SNPs within 2kb
    855 from dbSNP Build 142
  • Strain Annotations
    27
For selected strains:
Strain Gene Model ID Feature Type Coordinates Select Strains
C57BL/6J MGI_C57BL6J_1344361
 protein coding gene Chr9:108480141-108531917 (-)
129S1/SvImJ ENSMUSG00200038309
 protein coding gene Chr9:105695360-105719674 (-)
129S1/SvImJ ENSMUSGG00200054514
 protein coding gene Chr9:105685198-105689137 (-)
A/J ENSMUSGG00195054999
 protein coding gene Chr9:104903760-104907695 (-)
A/J ENSMUSG00195040912
 protein coding gene Chr9:104913918-104938223 (-)
AKR/J ENSMUSG00220026436
 protein coding gene Chr9:105301270-105325567 (-)
AKR/J ENSMUSGG00220054621
 protein coding gene Chr9:105291113-105295048 (-)
BALB/cJ ENSMUSGG00180055149
 protein coding gene Chr9:105220229-105224164 (-)
BALB/cJ ENSMUSG00180022089
 protein coding gene Chr9:105230387-105254688 (-)
C3H/HeJ ENSMUSGG00175055099
 protein coding gene Chr9:105562504-105566439 (-)
C3H/HeJ ENSMUSG00175040434
 protein coding gene Chr9:105572662-105596954 (-)
C57BL/6NJ ENSMUSG00215038856
 protein coding gene Chr9:105550069-105574379 (-)
C57BL/6NJ ENSMUSGG00215055250
 protein coding gene Chr9:105539905-105543844 (-)
CAROLI/EiJ MGP_CAROLIEiJ_G0032700
 protein coding gene Chr9:103945971-103997193 (-)
CAST/EiJ no annotation
CBA/J ENSMUSGG00210054675
 protein coding gene Chr9:105409960-105414141 (-)
CBA/J ENSMUSG00210039310
 protein coding gene Chr9:105420526-105446369 (-)
DBA/2J ENSMUSG00185040022
 protein coding gene Chr9:105582077-105606377 (-)
DBA/2J ENSMUSGG00185057930
 protein coding gene Chr9:105571930-105575855 (-)
FVB/NJ ENSMUSGG00205054120
 protein coding gene Chr9:105573328-105577263 (-)
FVB/NJ ENSMUSG00205039402
 protein coding gene Chr9:105583470-105607762 (-)
JF1/MsJ no annotation
LP/J ENSMUSG00230043667
 protein coding gene Chr9:105724164-105748477 (-)
LP/J ENSMUSGG00230055800
 protein coding gene Chr9:105714003-105717942 (-)
NOD/ShiLtJ ENSMUSGG00190054596
 protein coding gene Chr9:105210371-105214296 (-)
NOD/ShiLtJ ENSMUSG00190031387
 protein coding gene Chr9:105220518-105244815 (-)
NZO/HlLtJ ENSMUSG00225023158
 protein coding gene Chr9:105955299-105979597 (-)
NZO/HlLtJ ENSMUSGG00225055557
 protein coding gene Chr9:105945142-105949077 (-)
PWK/PhJ no annotation
SPRET/EiJ ENSMSPG00010034784
 protein coding gene Chr9:107180047-107228532 (-)
WSB/EiJ no annotation



Homology
more
  • Human Ortholog
    ARIH2, ariadne RBR E3 ubiquitin protein ligase 2
  • Vertebrate Orthologs
    3
Vertebrate Orthology Source
Alliance of Genome Resources
  • Human Ortholog
    ARIH2, ariadne RBR E3 ubiquitin protein ligase 2
  • Synonyms
    ARI2, TRIAD1
  • Links
    NCBI Gene ID: 10425
    UniProt: O95376

  • Chr Location
    3p21.31; chr3:48918821-48986382 (+)  GRCh38
Mutations,
Alleles, and
Phenotypes
less
  • Phenotype Summary
    21 phenotypes from 2 alleles in 3 genetic backgrounds
    1 phenotype from multigenic genotypes
    13 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
integument
immune system
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
neoplasm
vision/eye

Click cells to view annotations.
Homozygous inactivation of this gene causes altered dendritic cell physiology, enhanced liver apoptosis, and complete fetal lethality that is partially modified by genetic background. On a mixed genetic background, mice that survive past weaning succumb to a severe multiorgan inflammatory response.
Gene Ontology
(GO)
Classifications
less
  • All GO Annotations
    60
  • GO References
    12
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
RNA binding
signaling receptor activity
signaling receptor binding
transcription
transferase
transporter
Biological Process

carbohydrate derivative metabolism
cell differentiation
cell population proliferation
cellular component organization
DNA-templated transcription
establishment of localization
homeostatic process
immune system process
lipid metabolic process
programmed cell death
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
membraneless organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
protein-containing complex
synapse
vacuole
Click cells to view annotations.
Expression
less
Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
    763
  • Tissues
    51
  • cDNA Data
    13
  • Literature Summary
    2
  • Comparison Matrix
    Gene Expression + Phenotype
    • Sequences &
    Gene Models
    less
    Representative SequencesLengthStrain/SpeciesFlank
    genomic ENSMUSG00000064145 Ensembl Gene Model | MGI Sequence Detail 46445 C57BL/6J ±  kb
    transcript ENSMUST00000013338 Ensembl | MGI Sequence Detail 3924 Not Applicable  
    polypeptide ENSMUSP00000013338 Ensembl | MGI Sequence Detail 492 Not Applicable  
    For the selected sequence
    Protein
    Information
    less
    Molecular
    Reagents
    less
    • All nucleic 14
      cDNA 14

      Microarray probesets 7
    Other
    Accession IDs
    less
    MGI:2143135
    References
    more
    • Summaries
      All 53
      Developmental Gene Expression 2
      Gene Ontology 12
      Phenotypes 13
    • Earliest
      J:56275 Martinez-Noel G, et al., A family of structurally related RING finger proteins interacts specifically with the ubiquitin-conjugating enzyme UbcM4. FEBS Lett. 1999 Jul 9;454(3):257-61
    • Latest
      J:371297 Wang L, et al., YTHDC1 promotes postnatal brown adipose tissue development and thermogenesis by stabilizing PPARgamma. EMBO J. 2025 Jun;44(12):3360-3380
    Contributing Projects:
    Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
    Citing These Resources
    Funding Information
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    Send questions and comments to User Support.     		last database update
    09/01/2026
    MGI 6.24     		The Jackson Laboratory