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Katna1 Gene Detail
Summary
  • Symbol
    Katna1
  • Name
    katanin p60 (ATPase-containing) subunit A1
  • Feature Type
    protein coding gene
  • IDs
    MGI:1344353
    NCBI Gene: 23924
  • Alliance
    genome feature page
  • Transcription Start Sites
    5 TSS
Location &
Maps
more
  • Sequence Map
    Chr10:7601764-7638914 bp, + strand
    From Ensembl annotation of GRCm39
  • View this region in JBrowse
  • Genome Browsers
    Ensembl | UCSC | NCBI
  • Genetic Map
    Chromosome 10, 2.32 cM, cytoband A1
  • Mapping Data
    2 experiments
Strain
Comparison
more
  • SNPs within 2kb
    1093 from dbSNP Build 142
  • Strain Annotations
    19
For selected strains:
Strain Gene Model ID Feature Type Coordinates Select Strains
C57BL/6J MGI_C57BL6J_1344353
 protein coding gene Chr10:7601748-7638914 (+)
129S1/SvImJ ENSMUSG00200009028
 protein coding gene Chr10:4609257-4633699 (+)
A/J ENSMUSG00195008736
 protein coding gene Chr10:4497987-4522430 (+)
AKR/J ENSMUSG00220007037
 protein coding gene Chr10:4616309-4640750 (+)
BALB/cJ ENSMUSG00180020981
 protein coding gene Chr10:4660075-4684522 (+)
C3H/HeJ ENSMUSG00175012285
 protein coding gene Chr10:4650493-4673453 (+)
C57BL/6NJ ENSMUSG00215005025
 protein coding gene Chr10:4552702-4577127 (+)
CAROLI/EiJ MGP_CAROLIEiJ_G0015101
 protein coding gene Chr10:4296932-4334887 (+)
CAST/EiJ ENSTCUG00005017421
 protein coding gene Chr10:4607748-4645578 (+)
CBA/J ENSMUSG00210012489
 protein coding gene Chr10:4596167-4619130 (+)
DBA/2J ENSMUSG00185009402
 protein coding gene Chr10:4642646-4665606 (+)
FVB/NJ ENSMUSG00205008364
 protein coding gene Chr10:4595650-4618613 (+)
JF1/MsJ ENSUMUG00000026763
 protein coding gene Chr10:4730082-4753230 (+)
LP/J ENSMUSG00230014491
 protein coding gene Chr10:6259011-6283451 (+)
NOD/ShiLtJ ENSMUSG00190023384
 protein coding gene Chr10:4587712-4610672 (+)
NZO/HlLtJ ENSMUSG00225015935
 protein coding gene Chr10:10780636-10803608 (+)
PWK/PhJ ENSLUMG00010020118
 protein coding gene Chr10:4462047-4485181 (+)
SPRET/EiJ ENSMSPG00010006330
 protein coding gene Chr10:4808754-4842572 (+)
WSB/EiJ ENSIUOG00005013305
 protein coding gene Chr10:4523137-4547577 (+)



Homology
more
  • Human Ortholog
    KATNA1, katanin catalytic subunit A1
  • Vertebrate Orthologs
    3
Vertebrate Orthology Source
Alliance of Genome Resources
  • Human Ortholog
    KATNA1, katanin catalytic subunit A1
  • Links
    NCBI Gene ID: 11104
    UniProt: O75449

  • Chr Location
    6q25.1; chr6:149594873-149648990 (-)  GRCh38
Mutations,
Alleles, and
Phenotypes
less
  • Phenotype Summary
    11 phenotypes from 2 alleles in 2 genetic backgrounds
    14 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
integument
immune system
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
neoplasm
vision/eye

Click cells to view annotations.
Mice homozygous for a null allele exhibit complete prenatal lethality. Heterozygous null mice exhibit altered neuronal progenitor proliferation in the developing cortex and during adult hippocampal neurogenesis.
Gene Ontology
(GO)
Classifications
less
  • All GO Annotations
    60
  • GO References
    15
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
RNA binding
signaling receptor activity
signaling receptor binding
transcription
transferase
transporter
Biological Process

carbohydrate derivative metabolism
cell differentiation
cell population proliferation
cellular component organization
DNA-templated transcription
establishment of localization
homeostatic process
immune system process
lipid metabolic process
programmed cell death
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
membraneless organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
protein-containing complex
synapse
vacuole
Click cells to view annotations.
Expression
less
Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
    614
  • Tissues
    15
  • cDNA Data
    9
  • Literature Summary
    7
  • Comparison Matrix
    Gene Expression + Phenotype
    • Sequences &
    Gene Models
    less
    Representative SequencesLengthStrain/SpeciesFlank
    genomic ENSMUSG00000019794 Ensembl Gene Model | MGI Sequence Detail 37151 C57BL/6J ±  kb
    transcript ENSMUST00000165806 Ensembl | MGI Sequence Detail 1775 Not Applicable  
    polypeptide ENSMUSP00000132514 Ensembl | MGI Sequence Detail 493 Not Applicable  
    For the selected sequence
    Protein
    Information
    less
    Molecular
    Reagents
    less
    • All nucleic 10
      cDNA 9
      Primer pair 1

      Microarray probesets 3
    References
    more
    • Summaries
      All 59
      Developmental Gene Expression 7
      Gene Ontology 15
      Phenotypes 14
    • Earliest
      J:56613 Syu LJ, et al., Lipotransin: a novel docking protein for hormone-sensitive lipase. Mol Cell. 1999 Jul;4(1):109-15
    • Latest
      J:371511 Yuen WS, et al., Fertility is compromised after oocyte-specific deletion of microtubule severing protein Katanin A1. Mol Hum Reprod. 2025 Jul 3;31(3)
    Contributing Projects:
    Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
    Citing These Resources
    Funding Information
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    Send questions and comments to User Support.     		last database update
    09/08/2026
    MGI 6.24     		The Jackson Laboratory