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Mfap4 Gene Detail
Summary
  • Symbol
    Mfap4
  • Name
    microfibrillar-associated protein 4
  • Synonyms
    1110007F23Rik
  • Feature Type
    protein coding gene
  • IDs
    MGI:1342276
    NCBI Gene: 76293
  • Alliance
    genome feature page
  • Transcription Start Sites
    20 TSS
Location &
Maps
more
  • Sequence Map
    Chr11:61376257-61379536 bp, + strand
    From NCBI annotation of GRCm39
  • View this region in JBrowse
  • Genome Browsers
    Ensembl | UCSC | NCBI
  • Genetic Map
    Chromosome 11, 37.96 cM, cytoband B2
  • Mapping Data
    4 experiments
Strain
Comparison
more
  • SNPs within 2kb
    125 from dbSNP Build 142
  • Strain Annotations
    19
For selected strains:
Strain Gene Model ID Feature Type Coordinates Select Strains
C57BL/6J MGI_C57BL6J_1342276
 protein coding gene Chr11:61376257-61379726 (+)
129S1/SvImJ ENSMUSG00200036112
 protein coding gene Chr11:58294441-58297909 (+)
A/J ENSMUSG00195038206
 protein coding gene Chr11:58335585-58339055 (+)
AKR/J ENSMUSG00220039889
 protein coding gene Chr11:58436608-58440078 (+)
BALB/cJ ENSMUSG00180045824
 protein coding gene Chr11:58388689-58392161 (+)
C3H/HeJ ENSMUSG00175037160
 protein coding gene Chr11:58352801-58356270 (+)
C57BL/6NJ ENSMUSG00215019370
 protein coding gene Chr11:58095747-58099217 (+)
CAROLI/EiJ MGP_CAROLIEiJ_G0016477
 protein coding gene Chr11:56305851-56309344 (+)
CAST/EiJ ENSTCUG00005038634
 protein coding gene Chr11:57881614-57885072 (+)
CBA/J ENSMUSG00210034624
 protein coding gene Chr11:58185822-58189291 (+)
DBA/2J ENSMUSG00185039157
 protein coding gene Chr11:58368698-58372164 (+)
FVB/NJ ENSMUSG00205027223
 protein coding gene Chr11:58259200-58262667 (+)
JF1/MsJ ENSUMUG00000040522
 protein coding gene Chr11:58776653-58780106 (+)
LP/J ENSMUSG00230044882
 protein coding gene Chr11:59515721-59519189 (+)
NOD/ShiLtJ ENSMUSG00190042024
 protein coding gene Chr11:58368188-58371655 (+)
NZO/HlLtJ ENSMUSG00225044395
 protein coding gene Chr11:61659101-61662568 (+)
PWK/PhJ ENSLUMG00010023685
 protein coding gene Chr11:58299077-58302530 (+)
SPRET/EiJ ENSMSPG00010030188
 protein coding gene Chr11:58971551-58974942 (+)
WSB/EiJ ENSIUOG00005035263
 protein coding gene Chr11:58286476-58289941 (+)



Homology
more
  • Human Ortholog
    MFAP4, microfibril associated protein 4
  • Vertebrate Orthologs
    14
Vertebrate Orthology Source
Alliance of Genome Resources
  • Human Ortholog
    MFAP4, microfibril associated protein 4
  • Links
    NCBI Gene ID: 4239
    UniProt: P55083

  • Chr Location
    17p11.2; chr17:19383442-19387197 (-)  GRCh38
Mutations,
Alleles, and
Phenotypes
less
  • Phenotype Summary
    7 phenotypes from 2 alleles in 2 genetic backgrounds
    21 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
integument
immune system
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
neoplasm
vision/eye

Click cells to view annotations.
Mice homozygous for a knock-out allele exhibit spontaneous air space enlargement in female mice.
Gene Ontology
(GO)
Classifications
less
  • All GO Annotations
    25
  • GO References
    8
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
RNA binding
signaling receptor activity
signaling receptor binding
transcription
transferase
transporter
Biological Process

carbohydrate derivative metabolism
cell differentiation
cell population proliferation
cellular component organization
DNA-templated transcription
establishment of localization
homeostatic process
immune system process
lipid metabolic process
programmed cell death
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
membraneless organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
protein-containing complex
synapse
vacuole
Click cells to view annotations.
Expression
less
Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
    725
  • Tissues
    104
  • cDNA Data
    62
  • Literature Summary
    15
  • Comparison Matrix
    Gene Expression + Phenotype
    • Sequences &
    Gene Models
    less
    Representative SequencesLengthStrain/SpeciesFlank
    genomic 76293 NCBI Gene Model | MGI Sequence Detail 3280 C57BL/6J ±  kb
    transcript NM_001347545 RefSeq | MGI Sequence Detail 1617 ZRU/MplStud  
    polypeptide Q9D1H9 UniProt | EBI | MGI Sequence Detail 257 Not Applicable  
    For the selected sequence
    Protein
    Information
    less
    • UniProt
      1 Sequence
    • Protein Ontology
      PR:000010364 microfibril-associated glycoprotein 4
      (term hierarchy)
    • InterPro Domains
      IPR002181 Fibrinogen, alpha/beta/gamma chain, C-terminal globular domain
      IPR014716 Fibrinogen, alpha/beta/gamma chain, C-terminal globular, subdomain 1
      IPR050373 Fibrinogen C-terminal domain-containing protein
      IPR036056 Fibrinogen-like, C-terminal
    • GlyGen
      Q9D1H9 2 sites, 3 N-linked glycans (2 sites)
    Molecular
    Reagents
    less
    • All nucleic 63
      cDNA 62
      Other 1

      Microarray probesets 4
    Other
    Accession IDs
    less
    MGI:1923543
    References
    more
    • Summaries
      All 71
      Developmental Gene Expression 15
      Gene Ontology 8
      Phenotypes 21
    • Earliest
      J:137335 Roderick TH, Chromosomal inversions in studies of mammalian mutagenesis. Genetics. 1979 May;92(1 Pt 1 Suppl):s121-6
    • Latest
      J:378516 Manning E, et al., Resolving forebrain developmental organisation by analysis of differential growth patterns. Nat Commun. 2025 Dec 21;17(1):901
    Contributing Projects:
    Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
    Citing These Resources
    Funding Information
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    Send questions and comments to User Support.     		last database update
    09/08/2026
    MGI 6.24     		The Jackson Laboratory