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Gstz1 Gene Detail
Summary
  • Symbol
    Gstz1
  • Name
    glutathione transferase zeta 1 (maleylacetoacetate isomerase)
  • Synonyms
    maleylacetoacetate isomerase
  • Feature Type
    protein coding gene
  • IDs
    MGI:1341859
    NCBI Gene: 14874
  • Alliance
    gene page
  • Transcription Start Sites
    11 TSS
Location &
Maps
more
  • Sequence Map
    Chr12:87193939-87211497 bp, + strand
    From Ensembl annotation of GRCm39
  • View this region in JBrowse
  • Genome Browsers
    Ensembl | UCSC | NCBI
  • Genetic Map
    Chromosome 12, 41.34 cM, cytoband E
  • Mapping Data
    2 experiments
Strain
Comparison
more
  • SNPs within 2kb
    123 from dbSNP Build 142
  • Strain Annotations
    18
For selected strains:
Strain Gene Model ID Feature Type Coordinates Select Strains
C57BL/6J MGI_C57BL6J_1341859
 protein coding gene Chr12:87192102-87211497 (+)
129S1/SvImJ MGP_129S1SvImJ_G0019979
 protein coding gene Chr12:88043043-88060040 (+)
A/J MGP_AJ_G0019937
 protein coding gene Chr12:84695532-84715003 (+)
AKR/J MGP_AKRJ_G0019912
 protein coding gene Chr12:86992475-87013965 (+)
BALB/cJ MGP_BALBcJ_G0019916
 protein coding gene Chr12:85028415-85048073 (+)
C3H/HeJ MGP_C3HHeJ_G0019722
 protein coding gene Chr12:87481280-87500915 (+)
C57BL/6NJ MGP_C57BL6NJ_G0020368
 protein coding gene Chr12:90573075-90589523 (+)
CAROLI/EiJ MGP_CAROLIEiJ_G0017986
 protein coding gene Chr12:81580279-81591880 (+)
CAST/EiJ MGP_CASTEiJ_G0019272
 protein coding gene Chr12:82506543-82523116 (+)
CBA/J MGP_CBAJ_G0019694
 protein coding gene Chr12:94058885-94079832 (+)
DBA/2J MGP_DBA2J_G0019807
 protein coding gene Chr12:84184132-84209537 (+)
FVB/NJ MGP_FVBNJ_G0019794
 protein coding gene Chr12:83178483-83203257 (+)
LP/J MGP_LPJ_G0019881
 protein coding gene Chr12:87918968-87942417 (+)
NOD/ShiLtJ MGP_NODShiLtJ_G0019833
 protein coding gene Chr12:96804336-96836791 (+)
NZO/HlLtJ MGP_NZOHlLtJ_G0020400
 protein coding gene Chr12:86620061-86643737 (+)
PWK/PhJ MGP_PWKPhJ_G0019036
 protein coding gene Chr12:78742630-78762007 (+)
SPRET/EiJ MGP_SPRETEiJ_G0018831
 protein coding gene Chr12:81114224-81135862 (+)
WSB/EiJ MGP_WSBEiJ_G0019325
 protein coding gene Chr12:87396159-87419356 (+)



Homology
more
  • Human Ortholog
    GSTZ1, glutathione S-transferase zeta 1
  • Vertebrate Orthologs
    3
Vertebrate Orthology Source
Alliance of Genome Resources
  • Human Ortholog
    GSTZ1, glutathione S-transferase zeta 1
  • Synonyms
    GSTZ1-1, MAAI, MAAID, MAI
  • Links
    NCBI Gene ID: 2954
    neXtProt AC: NX_O43708
    UniProt: O43708

  • Chr Location
    14q24.3; chr14:77320996-77331597 (+)  GRCh38
Mutations,
Alleles, and
Phenotypes
less
  • Phenotype Summary
    24 phenotypes from 2 alleles in 2 genetic backgrounds
    15 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
integument
immune system
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
neoplasm
vision/eye

Click cells to view annotations.
Mice homozygous for disruptions in this gene have essentially normal phenotypes but do display ketoaciduria and severe sensitivity to diets high in tyrosine or phenylalanine.
Gene Ontology
(GO)
Classifications
less
  • All GO Annotations
    17
  • GO References
    5
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
RNA binding
signaling receptor activity
signaling receptor binding
transcription
transferase
transporter
Biological Process

carbohydrate derivative metabolism
cell differentiation
cell population proliferation
cellular component organization
DNA-templated transcription
establishment of localization
homeostatic process
immune system process
lipid metabolic process
programmed cell death
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
non-membrane-bounded organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
protein-containing complex
synapse
vacuole
Click cells to view annotations.
Expression
less
Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
    810
  • Tissues
    100
  • cDNA Data
    131
  • Literature Summary
    4
  • Comparison Matrix
    Gene Expression + Phenotype
    • Sequences &
    Gene Models
    less
    Representative SequencesLengthStrain/SpeciesFlank
    genomic ENSMUSG00000021033 Ensembl Gene Model | MGI Sequence Detail 17559 C57BL/6J ±  kb
    transcript ENSMUST00000063117 Ensembl | MGI Sequence Detail 1656 Not Applicable  
    polypeptide ENSMUSP00000053540 Ensembl | MGI Sequence Detail 216 Not Applicable  
    For the selected sequence
    Protein
    Information
    less
    Molecular
    Reagents
    less
    • All nucleic 131
      cDNA 131

      Microarray probesets 3
    References
    more
    • Summaries
      All 42
      Developmental Gene Expression 4
      Gene Ontology 5
      Phenotypes 15
    • Earliest
      J:56027 Fernandez-Canon JM, et al., Gene structure, chromosomal location, and expression pattern of maleylacetoacetate isomerase. Genomics. 1999 Jun 15;58(3):263-9
    • Latest
      J:346520 Luo H, et al., Signaling metabolite succinylacetone activates HIF-1alpha and promotes angiogenesis in GSTZ1-deficient hepatocellular carcinoma. JCI Insight. 2023 Oct 31;8(23)
    Contributing Projects:
    Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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    Funding Information
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    Send questions and comments to User Support.     		last database update
    04/16/2024
    MGI 6.23     		The Jackson Laboratory