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Spink4 Gene Detail
Summary
  • Symbol
    Spink4
  • Name
    serine peptidase inhibitor, Kazal type 4
  • Synonyms
    MPGC60
  • Feature Type
    protein coding gene
  • IDs
    MGI:1341848
    NCBI Gene: 20731
  • Alliance
    genome feature page
  • Transcription Start Sites
    1 TSS
Location &
Maps
more
  • Sequence Map
    Chr4:40920056-40931395 bp, + strand
    From NCBI annotation of GRCm39
  • View this region in JBrowse
  • Genome Browsers
    Ensembl | UCSC | NCBI
  • Genetic Map
    Chromosome 4, 20.64 cM, cytoband A
  • Mapping Data
    1 experiment
Strain
Comparison
more
  • SNPs within 2kb
    443 from dbSNP Build 142
  • Strain Annotations
    14
For selected strains:
Strain Gene Model ID Feature Type Coordinates Select Strains
C57BL/6J MGI_C57BL6J_1341848
 protein coding gene Chr4:40920052-40931395 (+)
129S1/SvImJ ENSMUSG00200005135
 protein coding gene Chr4:37761892-37773236 (+)
A/J ENSMUSG00195002795
 protein coding gene Chr4:38137753-38149091 (+)
AKR/J ENSMUSG00220032629
 protein coding gene Chr4:37965804-37977142 (+)
BALB/cJ ENSMUSG00180022496
 protein coding gene Chr4:37724541-37735885 (+)
C3H/HeJ ENSMUSG00175021184
 protein coding gene Chr4:38103208-38114546 (+)
C57BL/6NJ ENSMUSG00215013494
 protein coding gene Chr4:37740813-37752156 (+)
CAROLI/EiJ MGP_CAROLIEiJ_G0025901
 protein coding gene Chr4:35016546-35028280 (+)
CAST/EiJ no annotation
CBA/J ENSMUSG00210007550
 protein coding gene Chr4:37804133-37815475 (+)
DBA/2J ENSMUSG00185006409
 protein coding gene Chr4:37877882-37889226 (+)
FVB/NJ ENSMUSG00205026723
 protein coding gene Chr4:37428624-37439965 (+)
JF1/MsJ no annotation
LP/J ENSMUSG00230041510
 protein coding gene Chr4:41255501-41266844 (+)
NOD/ShiLtJ ENSMUSG00190005287
 protein coding gene Chr4:37827122-37838460 (+)
NZO/HlLtJ ENSMUSG00225005764
 protein coding gene Chr4:45136103-45147447 (+)
PWK/PhJ no annotation
SPRET/EiJ no annotation
WSB/EiJ no annotation



Homology
more
  • Human Ortholog
    SPINK4, serine peptidase inhibitor Kazal type 4
  • Vertebrate Orthologs
    3
Vertebrate Orthology Source
Alliance of Genome Resources
  • Human Ortholog
    SPINK4, serine peptidase inhibitor Kazal type 4
  • Synonyms
    HEL136, PEC-60, PEC60
  • Links
    NCBI Gene ID: 27290
    UniProt: O60575

  • Chr Location
    9p13.3; chr9:33218365-33248567 (+)  GRCh38
Mutations,
Alleles, and
Phenotypes
less
  • Phenotype Summary
    10 phenotype references
Gene Ontology
(GO)
Classifications
less
  • All GO Annotations
    2
  • GO References
    2
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
RNA binding
signaling receptor activity
signaling receptor binding
transcription
transferase
transporter
Biological Process

carbohydrate derivative metabolism
cell differentiation
cell population proliferation
cellular component organization
DNA-templated transcription
establishment of localization
homeostatic process
immune system process
lipid metabolic process
programmed cell death
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
membraneless organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
protein-containing complex
synapse
vacuole
Click cells to view annotations.
Expression
less
Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
    659
  • Tissues
    9
  • cDNA Data
    17
  • Literature Summary
    3
Sequences &
Gene Models
less
Representative SequencesLengthStrain/SpeciesFlank
genomic 20731 NCBI Gene Model | MGI Sequence Detail 11340 C57BL/6J ±  kb
transcript NM_011463 RefSeq | MGI Sequence Detail 402 Not Specified  
polypeptide O35679 UniProt | EBI | MGI Sequence Detail 86 Not Applicable  
For the selected sequence
Protein
Information
less
Molecular
Reagents
less
  • All nucleic 18
    Genomic 1
    cDNA 17

    Microarray probesets 3
References
more
  • Summaries
    All 33
    Developmental Gene Expression 3
    Gene Ontology 2
    Phenotypes 10
  • Earliest
    J:50679 Krause R, et al., Molecular cloning and characterization of murine Mpgc60, a gene predominantly expressed in the intestinal tract. Differentiation. 1998 Sep;63(5):285-94
  • Latest
    J:351990 Wang Y, et al., Therapeutic potential of the secreted Kazal-type serine protease inhibitor SPINK4 in colitis. Nat Commun. 2024 Jul 12;15(1):5874
Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
Citing These Resources
Funding Information
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Send questions and comments to User Support. 		last database update
09/15/2026
MGI 6.29 		The Jackson Laboratory