Kcnh1 MGI Mouse Gene Detail - MGI:1341721 - potassium voltage-gated channel, subfamily H (eag-related), member 1

Symbol

Kcnh1
Name

potassium voltage-gated channel, subfamily H (eag-related), member 1
Synonyms

Eag1, ether a go-go, Kv10.1

Feature Type

protein coding gene
IDs

MGI:1341721
NCBI Gene: 16510
Alliance

genome feature page
Transcription Start Sites

1 TSS

Sequence Map

Chr1:191873082-192192467 bp, + strand
From Ensembl annotation of GRCm39
View this region in JBrowse
Genome Browsers

Ensembl | UCSC | NCBI

Genetic Map

Chromosome 1, 97.33 cM
Mapping Data

1 experiment

SNPs within 2kb

8839 from dbSNP Build 142
Strain Annotations

18

For selected strains:

Strain	Gene Model ID	Feature Type	Coordinates
C57BL/6J	MGI_C57BL6J_1341721	protein coding gene	Chr1:191871759-192192467 (+)
129S1/SvImJ	ENSMUSG00200003965	protein coding gene	Chr1:189651890-189970013 (+)
A/J	ENSMUSG00195008189	protein coding gene	Chr1:189225847-189543993 (+)
AKR/J	ENSMUSG00220004606	protein coding gene	Chr1:188469710-188787860 (+)
BALB/cJ	ENSMUSG00180016347	protein coding gene	Chr1:189291281-189609438 (+)
C3H/HeJ	ENSMUSG00175021419	protein coding gene	Chr1:189479186-189797297 (+)
C57BL/6NJ	ENSMUSG00215017979	protein coding gene	Chr1:188706302-189025562 (+)
CAROLI/EiJ	MGP_CAROLIEiJ_G0015060	protein coding gene	Chr1:181942768-182251211 (+)
CAST/EiJ	ENSTCUG00005001765	protein coding gene	Chr1:187261517-187575157 (+)
CBA/J	ENSMUSG00210003450	protein coding gene	Chr1:189146914-189488475 (+)
DBA/2J	ENSMUSG00185010372	protein coding gene	Chr1:193760186-194089113 (+)
FVB/NJ	ENSMUSG00205004212	protein coding gene	Chr1:188137284-188457402 (+)
JF1/MsJ	ENSUMUG00000006941	protein coding gene	Chr1:192733064-193047837 (+)
LP/J	ENSMUSG00230021671	protein coding gene	Chr1:193290068-193608173 (+)
NOD/ShiLtJ	ENSMUSG00190027520	protein coding gene	Chr1:189117104-189435229 (+)
NZO/HlLtJ	ENSMUSG00225015619	protein coding gene	Chr1:197037624-197359956 (+)
PWK/PhJ	ENSLUMG00010006098	protein coding gene	Chr1:187979181-188297314 (+)
SPRET/EiJ	no annotation
WSB/EiJ	ENSIUOG00005004451	protein coding gene	Chr1:188474714-188790623 (+)

Human Ortholog

KCNH1, potassium voltage-gated channel subfamily H member 1

Vertebrate Orthologs

4

Vertebrate Orthology Source

Alliance of Genome Resources

Human Ortholog

KCNH1, potassium voltage-gated channel subfamily H member 1
Synonyms

EAG, EAG1, h-eag, hEAG, hEAG1, Kv10.1, K(V)10.1, TMBTS, ZLS1
Links

HGNC:6250

NCBI Gene ID: 3756

UniProt: O95259
Chr Location

1q32.2; chr1:210676823-211134183 (-) GRCh38

MGI Vertebrate Homology

Kcnh1 stringent orthology
1 human;1 mouse;1 rat;2 zebrafish
HCOP

vertebrate homology predictions: KCNH1
Gene Tree

Kcnh1

Diseases

1 with human KCNH1 associations

				Human Disease	Mouse Models
				colorectal adenocarcinoma IDs colorectal adenocarcinoma DOID:0050861 NCI:C5105 UMLS_CUI:C1319315

Click on a disease name to see all genes associated with that disease.

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Phenotype Summary

4 phenotypes from 2 alleles in 2 genetic backgrounds
7 phenotype references

Phenotype Overview

Blue squares indicate phenotypes directly attributed to mutations/alleles of this gene.

adipose tissue	behavior/neurological	cardiovascular system	cellular	craniofacial	digestive/alimentary system	embryo	endocrine/exocrine glands	growth/size/body	hearing/vestibular/ear	hematopoietic system	homeostasis/metabolism	integument	immune system	limbs/digits/tail	liver/biliary system	mortality/aging	muscle	nervous system	pigmentation	renal/urinary system	reproductive system	respiratory system	skeleton	taste/olfaction	neoplasm	vision/eye

Click cells to view annotations.

All Mutations and Alleles

9
Endonuclease-mediated

7
Targeted

2
Incidental Mutations

Mutagenetix , APF
Find Mice (IMSR)

60 strains or lines available

Homozygous mutant mice exhibit a decreased depressive-like response during tail suspension testing. Mice homozygous for a different knock-out allele exhibit longer latency to move in haloperidol-treated mice and mild hyperactivity.

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All GO Annotations

80
GO References

11

Molecular Function

carbohydrate derivative binding	cytoskeletal protein binding	DNA binding	enzyme regulator	hydrolase	ligase	lipid binding	oxidoreductase	RNA binding	signaling receptor activity	signaling receptor binding	transcription	transferase	transporter

Biological Process

carbohydrate derivative metabolism	cell differentiation	cell population proliferation	cellular component organization	DNA-templated transcription	establishment of localization	homeostatic process	immune system process	lipid metabolic process	programmed cell death	protein metabolic process	response to stimulus	signaling	system development

Cellular Component

cell projection	cytoplasmic vesicle	cytoskeleton	cytosol	endoplasmic reticulum	endosome	extracellular region	Golgi apparatus	mitochondrion	membraneless organelle	nucleus	organelle envelope	organelle lumen	plasma membrane	protein-containing complex	synapse	vacuole

Click cells to view annotations.

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Expression Overview

GXD's primary emphasis is on endogenous gene expression during development. Click on grid cells to view annotations.

Blue cells = expressed in wild-type.
Gray triangles = other expression annotations only
(e.g. absence of expression or data from mutants).

early conceptus	embryo ectoderm	embryo endoderm	embryo mesoderm	embryo mesenchyme	extraembryonic component	alimentary system	auditory system	branchial arches	cardiovascular system	connective tissue	endocrine system	exocrine system	hemolymphoid system	integumental system	limbs	liver and biliary system	musculoskeletal system	nervous system	olfactory system	reproductive system	respiratory system	urinary system	visual system

Click cells to view annotations.

Assay Results

646
Tissues

47
cDNA Data

26
Literature Summary

6

Images

Tissue x Stage Matrix

Other Mouse Links

Allen Institute

GEO

Expression Atlas
Other Vertebrate Links

ZFIN kcnh1a, kcnh1b

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All Sequences

52
RefSeq

9
UniProt

6
CCDS

CCDS15627.1, CCDS35826.1

Ensembl

ENSMUSG00000058248 (Evidence)
NCBI Gene

16510

			Length	Strain/Species	Flank
genomic	ENSMUSG00000058248	Ensembl Gene Model \| MGI Sequence Detail	319386	C57BL/6J	± kb
transcript	ENSMUST00000078470	Ensembl \| MGI Sequence Detail	7242	Not Applicable
polypeptide	ENSMUSP00000077563	Ensembl \| MGI Sequence Detail	989	Not Applicable

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UniProt

6 Sequences
Protein Ontology

PR:000000790 voltage-gated delayed rectifier potassium channel KCNH1

(term hierarchy)
PDB

4F8A, 4HOI, 4LLO, 5HIT
InterPro Domains

IPR000595 Cyclic nucleotide-binding domain

IPR018490 Cyclic nucleotide-binding domain superfamily

IPR005821 Ion transport domain

IPR001610 PAC motif

IPR000700 PAS-associated, C-terminal

IPR000014 PAS domain

IPR035965 PAS domain superfamily

IPR003949 Potassium channel, voltage-dependent, EAG

IPR003938 Potassium channel, voltage-dependent, EAG/ELK/ERG-like

IPR050818 Potassium channel, voltage-dependent, EAG/ELK/ERG-like, animal-type

IPR014710 PpnP-like, jelly roll fold
GlyGen

Q60603 5 sites, 1 N-linked glycan (1 site), 1 O-linked glycan (3 sites)

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All nucleic 29

Genomic 1

cDNA 26

Primer pair 2

Microarray probesets 4

Summaries

All 48

Developmental Gene Expression 6

Gene Ontology 11

Phenotypes 7
Earliest

J:18517 Warmke JW, et al., A family of potassium channel genes related to eag in Drosophila and mammals. Proc Natl Acad Sci U S A. 1994 Apr 12;91(8):3438-42
Latest

J:380949 Kiyama T, et al., Tbr2-dependent parallel pathways regulate the development of distinct ipRGC subtypes. Commun Biol. 2026 Feb 1;9(1)

TSS for Kcnh1:

(View these features in JBrowse)

Transcription Start Site	Location	Distance from Gene 5'-end
Tssr10802	Chr1:191873079-191873129 (+)	22 bp

Contributing Projects: Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
Citing These Resources Funding Information Warranty Disclaimer, Privacy Notice, Licensing, & Copyright Send questions and comments to User Support.	last database update 09/08/2026 MGI 6.24