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Scnm1 Gene Detail
Summary
  • Symbol
    Scnm1
  • Name
    sodium channel modifier 1
  • Synonyms
    3110001I17Rik, Scnm1-ps
  • Feature Type
    protein coding gene
  • IDs
    MGI:1341284
    NCBI Gene: 69269
  • Alliance
    gene page
  • Transcription Start Sites
    3 TSS
Location &
Maps
more
  • Sequence Map
    Chr3:95037030-95041285 bp, - strand
    From NCBI annotation of GRCm39
  • View this region in JBrowse
  • Genome Browsers
    Ensembl | UCSC | NCBI
  • Genetic Map
    Chromosome 3, 40.74 cM, cytoband F2
  • Mapping Data
    7 experiments
Strain
Comparison
more
  • SNPs within 2kb
    50 from dbSNP Build 142
  • Strain Annotations
    18
For selected strains:
Strain Gene Model ID Feature Type Coordinates Select Strains
C57BL/6J MGI_C57BL6J_1341284
 protein coding gene Chr3:95036847-95041322 (-)
129S1/SvImJ MGP_129S1SvImJ_G0027569
 protein coding gene Chr3:95823994-95828697 (-)
A/J MGP_AJ_G0027528
 protein coding gene Chr3:92868821-92872905 (-)
AKR/J MGP_AKRJ_G0027495
 protein coding gene Chr3:95011270-95015354 (-)
BALB/cJ MGP_BALBcJ_G0027540
 protein coding gene Chr3:92638045-92642129 (-)
C3H/HeJ MGP_C3HHeJ_G0027273
 protein coding gene Chr3:95291549-95295633 (-)
C57BL/6NJ MGP_C57BL6NJ_G0027988
 protein coding gene Chr3:99389585-99394005 (-)
CAROLI/EiJ MGP_CAROLIEiJ_G0025328
 protein coding gene Chr3:89230043-89234229 (-)
CAST/EiJ MGP_CASTEiJ_G0026723
 protein coding gene Chr3:94577845-94581923 (-)
CBA/J MGP_CBAJ_G0027250
 protein coding gene Chr3:102995846-102999930 (-)
DBA/2J MGP_DBA2J_G0027389
 protein coding gene Chr3:92161451-92165535 (-)
FVB/NJ MGP_FVBNJ_G0027360
 protein coding gene Chr3:90231066-90235150 (-)
LP/J MGP_LPJ_G0027498
 protein coding gene Chr3:97115011-97121717 (-)
NOD/ShiLtJ MGP_NODShiLtJ_G0027387
 protein coding gene Chr3:109119978-109126416 (-)
NZO/HlLtJ MGP_NZOHlLtJ_G0028042
 protein coding gene Chr3:94667004-94671189 (-)
PWK/PhJ MGP_PWKPhJ_G0026451
 protein coding gene Chr3:92037701-92042173 (-)
SPRET/EiJ MGP_SPRETEiJ_G0026272
 protein coding gene Chr3:92962064-92966324 (-)
WSB/EiJ MGP_WSBEiJ_G0026805
 protein coding gene Chr3:95050907-95054991 (-)



Homology
more
  • Human Ortholog
    SCNM1, sodium channel modifier 1
  • Vertebrate Orthologs
    3
Vertebrate Orthology Source
Alliance of Genome Resources
  • Human Ortholog
    SCNM1, sodium channel modifier 1
  • Synonyms
    OFD19
  • Links
    NCBI Gene ID: 79005
    neXtProt AC: NX_Q9BWG6
    UniProt: Q9BWG6

  • Chr Location
    1q21.3; chr1:151156664-151170296 (+)  GRCh38
Human Diseases
less
  • References
    1 with disease annotations
Mutations,
Alleles, and
Phenotypes
less
  • Phenotype Summary
    5 phenotypes from 2 alleles in 4 genetic backgrounds
    18 phenotypes from multigenic genotypes
    16 phenotype references
  • All Mutations and Alleles
    20
  • Chemically induced (ENU)
    2
  • Chemically induced (other)
    1
  • Gene trapped
    11
  • Radiation induced
    1
  • Spontaneous
    2
  • Targeted
    3
  • Genomic Mutations
    2 involving Scnm1
  • Incidental Mutations
    APF , CvDC
  • Find Mice (IMSR)
    17 strains or lines available
The Scnm1 locus influences the severity of the Scn8amed-J phenotype. Mice carrying the recesive susceptibility allele of the modifier are paralyzed and do not survive beyond 1 month. Mice carryimg the resistant allele display progressive dystonia with ataxia and live more than 1.5 years.
Gene Ontology
(GO)
Classifications
less
  • All GO Annotations
    9
  • GO References
    5
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
RNA binding
signaling receptor activity
signaling receptor binding
transcription
transferase
transporter
Biological Process

carbohydrate derivative metabolism
cell differentiation
cell population proliferation
cellular component organization
DNA-templated transcription
establishment of localization
homeostatic process
immune system process
lipid metabolic process
programmed cell death
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
non-membrane-bounded organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
protein-containing complex
synapse
vacuole
Click cells to view annotations.
Expression
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Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
    706
  • cDNA Data
    73
Sequences &
Gene Models
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Representative SequencesLengthStrain/SpeciesFlank
genomic 69269 NCBI Gene Model | MGI Sequence Detail 4256 C57BL/6J ±  kb
transcript NR_176904 RefSeq | MGI Sequence Detail 834 ZRU/MplStud  
polypeptide Q8K136 UniProt | EBI | MGI Sequence Detail 229 Not Applicable  
For the selected sequence
Protein
Information
less
Molecular
Reagents
less
  • All nucleic 73
    cDNA 73

    Microarray probesets 3
Other
Accession IDs
less
MGI:1916519
References
more
  • Summaries
    All 38
    Diseases 1
    Gene Ontology 5
    Phenotypes 16
  • Earliest
    J:53340 Sprunger LK, et al., Dystonia associated with mutation of the neuronal sodium channel Scn8a and identification of the modifier locus Scnm1 on mouse chromosome 3. Hum Mol Genet. 1999 Mar;8(3):471-9
  • Latest
    J:302829 Lu J, et al., Mouse models for human hyperuricaemia: a critical review. Nat Rev Rheumatol. 2019 Jul;15(7):413-426
Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
Citing These Resources
Funding Information
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Send questions and comments to User Support. 		last database update
04/16/2024
MGI 6.23 		The Jackson Laboratory