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Fcnb Gene Detail
Summary
  • Symbol
    Fcnb
  • Name
    ficolin B
  • Feature Type
    protein coding gene
  • IDs
    MGI:1341158
    NCBI Gene: 14134
  • Alliance
    genome feature page
  • Transcription Start Sites
    1 TSS
Location &
Maps
more
  • Sequence Map
    Chr2:27966491-27974921 bp, - strand
    From NCBI annotation of GRCm39
  • View this region in JBrowse
  • Genome Browsers
    Ensembl | UCSC | NCBI
  • Genetic Map
    Chromosome 2, 19.38 cM, cytoband A3
  • Mapping Data
    2 experiments
Strain
Comparison
more
  • SNPs within 2kb
    342 from dbSNP Build 142
  • Strain Annotations
    19
For selected strains:
Strain Gene Model ID Feature Type Coordinates Select Strains
C57BL/6J MGI_C57BL6J_1341158
 protein coding gene Chr2:27966390-27974921 (-)
129S1/SvImJ ENSMUSG00200047879
 protein coding gene Chr2:24932221-24940728 (-)
A/J ENSMUSG00195045908
 protein coding gene Chr2:25029065-25037572 (-)
AKR/J ENSMUSG00220049292
 protein coding gene Chr2:25146773-25155280 (-)
BALB/cJ ENSMUSG00180052035
 protein coding gene Chr2:25048075-25056582 (-)
C3H/HeJ ENSMUSG00175052898
 protein coding gene Chr2:25017359-25025866 (-)
C57BL/6NJ ENSMUSG00215048609
 protein coding gene Chr2:25076101-25084608 (-)
CAROLI/EiJ MGP_CAROLIEiJ_G0023346
 protein coding gene Chr2:23931658-23940173 (-)
CAST/EiJ ENSTCUG00005050517
 protein coding gene Chr2:24763760-24772257 (-)
CBA/J ENSMUSG00210017531
 protein coding gene Chr2:25050957-25059464 (-)
DBA/2J ENSMUSG00185047140
 protein coding gene Chr2:24943014-24951521 (-)
FVB/NJ ENSMUSG00205037963
 protein coding gene Chr2:24794821-24803328 (-)
JF1/MsJ ENSUMUG00000053796
 protein coding gene Chr2:24855206-24863704 (-)
LP/J ENSMUSG00230039858
 protein coding gene Chr2:26868107-26876614 (-)
NOD/ShiLtJ ENSMUSG00190050927
 protein coding gene Chr2:25049149-25057651 (-)
NZO/HlLtJ ENSMUSG00225008619
 protein coding gene Chr2:34619952-34628459 (-)
PWK/PhJ ENSLUMG00010049442
 protein coding gene Chr2:24932339-24940836 (-)
SPRET/EiJ ENSMSPG00010038714
 protein coding gene Chr2:25654837-25663350 (-)
WSB/EiJ ENSIUOG00005050295
 protein coding gene Chr2:24898317-24906824 (-)



Homology
more
  • Human Ortholog
    FCN1, ficolin 1
  • Vertebrate Orthologs
    3
Vertebrate Orthology Source
Alliance of Genome Resources
  • Human Ortholog
    FCN1, ficolin 1
  • Synonyms
    FCNM
  • Links
    NCBI Gene ID: 2219
    UniProt: O00602

  • Chr Location
    9q34.3; chr9:134903232-134917954 (-)  GRCh38
  • Human Ortholog
    FCN2, ficolin 2
  • Synonyms
    EBP-37, FCNL, ficolin-2, P35
  • Links
    NCBI Gene ID: 2220
    UniProt: Q15485

  • Chr Location
    9q34.3; chr9:134864144-134890508 (+)  GRCh38
Mutations,
Alleles, and
Phenotypes
less
  • Phenotype Summary
    2 phenotypes from 1 allele in 1 genetic background
    3 phenotypes from multigenic genotypes
    9 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
integument
immune system
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
neoplasm
vision/eye

Click cells to view annotations.
Mice homozygous for a knock-out allele exhibit increased susceptibility to Streptococcus pneumoniae infection.
Gene Ontology
(GO)
Classifications
less
  • All GO Annotations
    50
  • GO References
    6
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
RNA binding
signaling receptor activity
signaling receptor binding
transcription
transferase
transporter
Biological Process

carbohydrate derivative metabolism
cell differentiation
cell population proliferation
cellular component organization
DNA-templated transcription
establishment of localization
homeostatic process
immune system process
lipid metabolic process
programmed cell death
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
membraneless organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
protein-containing complex
synapse
vacuole
Click cells to view annotations.
Expression
less
Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
    655
  • Tissues
    27
  • cDNA Data
    8
  • Literature Summary
    4
Sequences &
Gene Models
less
Representative SequencesLengthStrain/SpeciesFlank
genomic 14134 NCBI Gene Model | MGI Sequence Detail 8431 C57BL/6J ±  kb
transcript NM_010190 RefSeq | MGI Sequence Detail 1062 Not Specified  
polypeptide O70497 UniProt | EBI | MGI Sequence Detail 314 Not Applicable  
For the selected sequence
Protein
Information
less
  • UniProt
    4 Sequences
  • InterPro Domains
    IPR008160 Collagen triple helix repeat
    IPR002181 Fibrinogen, alpha/beta/gamma chain, C-terminal globular domain
    IPR014716 Fibrinogen, alpha/beta/gamma chain, C-terminal globular, subdomain 1
    IPR020837 Fibrinogen, conserved site
    IPR050373 Fibrinogen C-terminal domain-containing protein
    IPR036056 Fibrinogen-like, C-terminal
  • GlyGen
    O70497 2 sites
Molecular
Reagents
less
  • All nucleic 12
    Genomic 2
    cDNA 8
    Primer pair 1
    Other 1

    Microarray probesets 2
References
more
  • Summaries
    All 39
    Developmental Gene Expression 4
    Gene Ontology 6
    Phenotypes 9
  • Earliest
    J:48250 Iwama A, et al., Use of RDA analysis of knockout mice to identify myeloid genes regulated in vivo by PU.1 and C/EBPalpha. Nucleic Acids Res. 1998 Jun 15;26(12):3034-43
  • Latest
    J:326541 Cyagen Biosciences Inc., Cyagen Biosciences Website. 2022;
Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
Citing These Resources
Funding Information
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Send questions and comments to User Support. 		last database update
09/08/2026
MGI 6.24 		The Jackson Laboratory