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Sgk1 Gene Detail
Summary
  • Symbol
    Sgk1
  • Name
    serum/glucocorticoid regulated kinase 1
  • Synonyms
    Sgk
  • Feature Type
    protein coding gene
  • IDs
    MGI:1340062
    NCBI Gene: 20393
  • Alliance
    gene page
  • Transcription Start Sites
    26 TSS
Location &
Maps
more
  • Sequence Map
    Chr10:21758083-21875802 bp, + strand
    From NCBI annotation of GRCm39
  • View this region in JBrowse
  • Genome Browsers
    Ensembl | UCSC | NCBI
  • Genetic Map
    Chromosome 10, 9.83 cM, cytoband A3
  • Mapping Data
    3 experiments
Strain
Comparison
more
  • SNPs within 2kb
    808 from dbSNP Build 142
  • Strain Annotations
    18
For selected strains:
Strain Gene Model ID Feature Type Coordinates Select Strains
C57BL/6J MGI_C57BL6J_1340062
 protein coding gene Chr10:21758083-21875802 (+)
129S1/SvImJ MGP_129S1SvImJ_G0017063
 protein coding gene Chr10:19702347-19823208 (+)
A/J MGP_AJ_G0017041
 protein coding gene Chr10:18951756-19070759 (+)
AKR/J MGP_AKRJ_G0017005
 protein coding gene Chr10:19285448-19419641 (+)
BALB/cJ MGP_BALBcJ_G0016999
 protein coding gene Chr10:19010510-19129906 (+)
C3H/HeJ MGP_C3HHeJ_G0016824
 protein coding gene Chr10:19611802-19741560 (+)
C57BL/6NJ MGP_C57BL6NJ_G0017461
 protein coding gene Chr10:20209309-20342885 (+)
CAROLI/EiJ MGP_CAROLIEiJ_G0015166
 protein coding gene Chr10:17910778-18027951 (+)
CAST/EiJ MGP_CASTEiJ_G0016406
 protein coding gene Chr10:19539173-19665136 (+)
CBA/J MGP_CBAJ_G0016796
 protein coding gene Chr10:21134516-21266357 (+)
DBA/2J MGP_DBA2J_G0016904
 protein coding gene Chr10:18820695-18940527 (+)
FVB/NJ MGP_FVBNJ_G0016899
 protein coding gene Chr10:18564984-18691837 (+)
LP/J MGP_LPJ_G0016979
 protein coding gene Chr10:19496496-19617978 (+)
NOD/ShiLtJ MGP_NODShiLtJ_G0016929
 protein coding gene Chr10:21300213-21421784 (+)
NZO/HlLtJ MGP_NZOHlLtJ_G0017499
 protein coding gene Chr10:19272507-19402368 (+)
PWK/PhJ MGP_PWKPhJ_G0016191
 protein coding gene Chr10:18742336-18864755 (+)
SPRET/EiJ MGP_SPRETEiJ_G0015974
 protein coding gene Chr10:19434526-19559879 (+)
WSB/EiJ MGP_WSBEiJ_G0016468
 protein coding gene Chr10:19367664-19489785 (+)



Homology
more
  • Human Ortholog
    SGK1, serum/glucocorticoid regulated kinase 1
  • Vertebrate Orthologs
    3
Vertebrate Orthology Source
Alliance of Genome Resources
  • Human Ortholog
    SGK1, serum/glucocorticoid regulated kinase 1
  • Synonyms
    SGK
  • Links
    NCBI Gene ID: 6446
    neXtProt AC: NX_O00141
    UniProt: O00141

  • Chr Location
    6q23.2; chr6:134169248-134318112 (-)  GRCh38
Human Diseases
more
  • Diseases
    1 with human SGK1 associations

Human Disease Mouse Models
      
IDs
Click on a disease name to see all genes associated with that disease.

Mutations,
Alleles, and
Phenotypes
less
  • Phenotype Summary
    8 phenotypes from 2 alleles in 3 genetic backgrounds
    68 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
integument
immune system
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
neoplasm
vision/eye

Click cells to view annotations.
Homozygous knockout results in reduced sensitivity to hypoxia-induced pulmonary arterial hypertension, inflammation and cardiac ventricular hypertrophy. But otherwise mice display an essentially normal phenotype. Sodium retention is compromised on a low salt diet.
Gene Ontology
(GO)
Classifications
less
  • All GO Annotations
    42
  • GO References
    13
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
RNA binding
signaling receptor activity
signaling receptor binding
transcription
transferase
transporter
Biological Process

carbohydrate derivative metabolism
cell differentiation
cell population proliferation
cellular component organization
DNA-templated transcription
establishment of localization
homeostatic process
immune system process
lipid metabolic process
programmed cell death
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
non-membrane-bounded organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
protein-containing complex
synapse
vacuole
Click cells to view annotations.
Expression
less
Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
    1014
  • Tissues
    116
  • cDNA Data
    213
  • Literature Summary
    18
  • Comparison Matrix
    Gene Expression + Phenotype
    • Sequences &
    Gene Models
    less
    Representative SequencesLengthStrain/SpeciesFlank
    genomic 20393 NCBI Gene Model | MGI Sequence Detail 117720 C57BL/6J ±  kb
    transcript NM_001161845 RefSeq | MGI Sequence Detail 3121 C57BL/6  
    polypeptide Q9WVC6 UniProt | EBI | MGI Sequence Detail 431 Not Applicable  
    For the selected sequence
    Protein
    Information
    less
    Molecular
    Reagents
    less
    • All nucleic 217
      cDNA 214
      Primer pair 2
      Other 1

      Microarray probesets 3
    References
    more
    • Summaries
      All 149
      Developmental Gene Expression 18
      Gene Ontology 13
      Phenotypes 68
    • Earliest
      J:137335 Roderick TH, Chromosomal inversions in studies of mammalian mutagenesis. Genetics. 1979 May;92(1 Pt 1 Suppl):s121-6
    • Latest
      J:341702 Han X, et al., SGK1 negatively regulates inflammatory immune responses and protects against alveolar bone loss through modulation of TRAF3 activity. J Biol Chem. 2022 Jun;298(6):102036
    Contributing Projects:
    Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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    Funding Information
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    Send questions and comments to User Support.     		last database update
    04/16/2024
    MGI 6.23     		The Jackson Laboratory