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Csf2rb Gene Detail
Summary
  • Symbol
    Csf2rb
  • Name
    colony stimulating factor 2 receptor, beta, low-affinity (granulocyte-macrophage)
  • Synonyms
    AIC2B, Bc, beta c, CDw131, common beta chain, Csf2rb1, Il3r, Il3rb1, Il5rb
  • Feature Type
    protein coding gene
  • IDs
    MGI:1339759
    NCBI Gene: 12983
  • Alliance
    gene page
  • Transcription Start Sites
    26 TSS
Location &
Maps
more
  • Sequence Map
    Chr15:78210000-78235201 bp, + strand
    From NCBI annotation of GRCm39
  • View this region in JBrowse
  • Genome Browsers
    Ensembl | UCSC | NCBI
  • Genetic Map
    Chromosome 15, 37.36 cM
  • Mapping Data
    5 experiments
Strain
Comparison
more
  • SNPs within 2kb
    178 from dbSNP Build 142
  • Strain Annotations
    8
  • PCR
    1
  • RFLP
    1
For selected strains:
Strain Gene Model ID Feature Type Coordinates Select Strains
C57BL/6J MGI_C57BL6J_1339759
 protein coding gene Chr15:78209952-78238047 (+)
129S1/SvImJ MGP_129S1SvImJ_G0022039
 protein coding gene Chr15:78512601-78542240 (+)
A/J MGP_AJ_G0022000
 protein coding gene Chr15:75718659-75733719 (-)
AKR/J no annotation
BALB/cJ no annotation
C3H/HeJ no annotation
C57BL/6NJ MGP_C57BL6NJ_G0022449
 protein coding gene Chr15:81604444-81638154 (+)
CAROLI/EiJ MGP_CAROLIEiJ_G0019979
 protein coding gene Chr15:72325088-72348571 (+)
CAST/EiJ no annotation
CBA/J no annotation
DBA/2J MGP_DBA2J_G0021871
 protein coding gene Chr15:75306094-75328954 (+)
FVB/NJ no annotation
LP/J no annotation
NOD/ShiLtJ no annotation
NZO/HlLtJ MGP_NZOHlLtJ_G0022463
 protein coding gene Chr15:77952184-77978291 (+)
PWK/PhJ no annotation
SPRET/EiJ MGP_SPRETEiJ_G0020876
 protein coding gene Chr15:77716366-77743971 (+)
WSB/EiJ no annotation



Homology
more
  • Human Ortholog
    CSF2RB, colony stimulating factor 2 receptor subunit beta
  • Vertebrate Orthologs
    3
Vertebrate Orthology Source
Alliance of Genome Resources
  • Human Ortholog
    CSF2RB, colony stimulating factor 2 receptor subunit beta
  • Synonyms
    betaGMR, CD131, CDw131, IL3RB, IL5RB, SMDP5
  • Links
    NCBI Gene ID: 1439
    neXtProt AC: NX_P32927
    UniProt: P32927

  • Chr Location
    22q12.3; chr22:36913628-36940439 (+)  GRCh38
Human Diseases
more
  • Diseases
    1 with Csf2rb mouse models; 1 with human CSF2RB associations

Human Disease Mouse Models
      
IDs
 View 2 models
Click on a disease name to see all genes associated with that disease.

  • Mutations/Alleles
    1 with disease annotations
  • References
    3 with disease annotations
Mutations,
Alleles, and
Phenotypes
less
  • Phenotype Summary
    13 phenotypes from 3 alleles in 4 genetic backgrounds
    20 phenotypes from multigenic genotypes
    111 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
integument
immune system
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
neoplasm
vision/eye

Click cells to view annotations.
Homozygotes for targeted null mutations exhibit lung pathology including lymphocytic infiltration, alveolar proteinosis-like areas, and increased saturated phosphatidylcholine pool sizes. Mutants also have low peripheral eosinophil numbers.
Gene Ontology
(GO)
Classifications
less
  • All GO Annotations
    17
  • GO References
    6
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
RNA binding
signaling receptor activity
signaling receptor binding
transcription
transferase
transporter
Biological Process

carbohydrate derivative metabolism
cell differentiation
cell population proliferation
cellular component organization
DNA-templated transcription
establishment of localization
homeostatic process
immune system process
lipid metabolic process
programmed cell death
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
non-membrane-bounded organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
protein-containing complex
synapse
vacuole
Click cells to view annotations.
Expression
less
Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
    729
  • Tissues
    18
  • cDNA Data
    46
  • Literature Summary
    9
  • Comparison Matrix
    Gene Expression + Phenotype
    • Sequences &
    Gene Models
    less
    Representative SequencesLengthStrain/SpeciesFlank
    genomic 12983 NCBI Gene Model | MGI Sequence Detail 25202 C57BL/6J ±  kb
    transcript NM_001358854 RefSeq | MGI Sequence Detail 4852 ZRU/MplStud  
    polypeptide P26955 UniProt | EBI | MGI Sequence Detail 896 Not Applicable  
    For the selected sequence
    Protein
    Information
    less
    • UniProt
      12 Sequences
    • InterPro Domains
      IPR011365 Cytokine IL-3/IL-5/GM-CSF receptor common beta chain
      IPR048668 Cytokine receptor common subunit beta, N-terminal
      IPR003961 Fibronectin type III
      IPR036116 Fibronectin type III superfamily
      IPR015152 Growth hormone/erythropoietin receptor, ligand binding
      IPR013783 Immunoglobulin-like fold
      IPR015373 Interferon/interleukin receptor domain
      IPR003531 Short hematopoietin receptor, family 1, conserved site
    Molecular
    Reagents
    less
    • All nucleic 59
      Genomic 3
      cDNA 50
      Primer pair 6

      Microarray probesets 7
    Other
    Accession IDs
    less
    MGD-MRK-11380, MGD-MRK-11382, MGD-MRK-11383, MGD-MRK-11390, MGD-MRK-2189, MGI:2146084, MGI:96554
    References
    more
    • Summaries
      All 173
      Developmental Gene Expression 9
      Diseases 3
      Gene Ontology 6
      Phenotypes 111
    • Earliest
      J:7688 Lane PW, et al., Association of megacolon with a new dominant spotting gene (Dom) in the mouse. J Hered. 1984 Nov-Dec;75(6):435-9
    • Latest
      J:340014 Pernet E, et al., Neonatal imprinting of alveolar macrophages via neutrophil-derived 12-HETE. Nature. 2023 Feb;614(7948):530-538
    Contributing Projects:
    Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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    Funding Information
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    Send questions and comments to User Support.     		last database update
    04/09/2024
    MGI 6.23     		The Jackson Laboratory