Myh8 MGI Mouse Gene Detail - MGI:1339712 - myosin, heavy polypeptide 8, skeletal muscle, perinatal

Symbol

Myh8
Name

myosin, heavy polypeptide 8, skeletal muscle, perinatal
Synonyms

4832426G23Rik, MyHC-pn, Myhs-p, Myhsp

Feature Type

protein coding gene
IDs

MGI:1339712
NCBI Gene: 17885
Alliance

genome feature page
Transcription Start Sites

14 TSS
Regulated by

Rr194, Rr196 (2 regulatory regions)

Sequence Map

Chr11:67167950-67199460 bp, + strand
From NCBI annotation of GRCm39
View this region in JBrowse
Genome Browsers

Ensembl | UCSC | NCBI

Genetic Map

Chromosome 11, 40.59 cM
Mapping Data

4 experiments

SNPs within 2kb

1109 from dbSNP Build 142
Strain Annotations

19
RFLP

2

For selected strains:

Strain	Gene Model ID	Feature Type	Coordinates
C57BL/6J	MGI_C57BL6J_1339712	protein coding gene	Chr11:67167950-67199460 (+)
129S1/SvImJ	ENSMUSG00200044519	protein coding gene	Chr11:64117013-64148508 (+)
A/J	ENSMUSG00195051244	protein coding gene	Chr11:64136301-64167798 (+)
AKR/J	ENSMUSG00220054038	protein coding gene	Chr11:64252618-64284113 (+)
BALB/cJ	ENSMUSG00180052842	protein coding gene	Chr11:64203530-64235010 (+)
C3H/HeJ	ENSMUSG00175053231	protein coding gene	Chr11:64153967-64185434 (+)
C57BL/6NJ	ENSMUSG00215054973	protein coding gene	Chr11:63936433-63967942 (+)
CAROLI/EiJ	MGP_CAROLIEiJ_G0016525	protein coding gene	Chr11:61994381-62024786 (+)
CAST/EiJ	ENSTCUG00005053641	protein coding gene	Chr11:63683883-63715070 (+)
CBA/J	ENSMUSG00210051431	protein coding gene	Chr11:64008036-64039506 (+)
DBA/2J	ENSMUSG00185053043	protein coding gene	Chr11:64202223-64233700 (+)
FVB/NJ	ENSMUSG00205053878	protein coding gene	Chr11:64101446-64132921 (+)
JF1/MsJ	ENSUMUG00000046487	protein coding gene	Chr11:64601211-64632250 (+)
LP/J	ENSMUSG00230052707	protein coding gene	Chr11:65327443-65358938 (+)
NOD/ShiLtJ	ENSMUSG00190053450	protein coding gene	Chr11:64234972-64266444 (+)
NZO/HlLtJ	ENSMUSG00225046174	protein coding gene	Chr11:67506877-67538377 (+)
PWK/PhJ	ENSLUMG00010053237	protein coding gene	Chr11:64119987-64151140 (+)
SPRET/EiJ	ENSMSPG00010043825	protein coding gene	Chr11:64846172-64877210 (+)
WSB/EiJ	ENSIUOG00005052525	protein coding gene	Chr11:64139070-64170591 (+)

Human Ortholog

MYH8, myosin heavy chain 8

Vertebrate Orthologs

9

Vertebrate Orthology Source

Alliance of Genome Resources

Human Ortholog

MYH8, myosin heavy chain 8
Synonyms

DA7, gtMHC-F, MyHC-peri, MyHC-pn
Links

HGNC:7578

NCBI Gene ID: 4626

UniProt: P13535
Chr Location

17p13.1; chr17:10390322-10421950 (-) GRCh38

MGI Vertebrate Homology

Myh8 stringent orthology
1 human;1 mouse;1 rat;7 zebrafish
HCOP

vertebrate homology predictions: MYH8
Gene Tree

Myh8

Diseases

3 with human MYH8 associations

				Human Disease	Mouse Models
				arthrogryposis multiplex congenita IDs arthrogryposis multiplex congenita DOID:0080954 OMIM:PS617468
				disease of cellular proliferation IDs disease of cellular proliferation DOID:14566 DOID:0000818
				distal arthrogryposis type 7 IDs distal arthrogryposis type 7 DOID:0111603 MESH:C535857 OMIM:121070 OMIM:158300 ORDO:3377

Click on a disease name to see all genes associated with that disease.

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Phenotype Summary

6 phenotypes from 1 allele in 1 genetic background
11 phenotype references

Phenotype Overview

Blue squares indicate phenotypes directly attributed to mutations/alleles of this gene.

adipose tissue	behavior/neurological	cardiovascular system	cellular	craniofacial	digestive/alimentary system	embryo	endocrine/exocrine glands	growth/size/body	hearing/vestibular/ear	hematopoietic system	homeostasis/metabolism	integument	immune system	limbs/digits/tail	liver/biliary system	mortality/aging	muscle	nervous system	pigmentation	renal/urinary system	reproductive system	respiratory system	skeleton	taste/olfaction	neoplasm	vision/eye

Click cells to view annotations.

All Mutations and Alleles

9
Chemically induced (other)

1
Endonuclease-mediated

4
Targeted

4
Genomic Mutations

1 involving Myh8
Incidental Mutations

Mutagenetix , APF , CvDC
Find Mice (IMSR)

105 strains or lines available
Comparison Matrix

Gene Expression + Phenotype

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All GO Annotations

28
GO References

8

Molecular Function

carbohydrate derivative binding	cytoskeletal protein binding	DNA binding	enzyme regulator	hydrolase	ligase	lipid binding	oxidoreductase	RNA binding	signaling receptor activity	signaling receptor binding	transcription	transferase	transporter

Biological Process

carbohydrate derivative metabolism	cell differentiation	cell population proliferation	cellular component organization	DNA-templated transcription	establishment of localization	homeostatic process	immune system process	lipid metabolic process	programmed cell death	protein metabolic process	response to stimulus	signaling	system development

Cellular Component

cell projection	cytoplasmic vesicle	cytoskeleton	cytosol	endoplasmic reticulum	endosome	extracellular region	Golgi apparatus	mitochondrion	membraneless organelle	nucleus	organelle envelope	organelle lumen	plasma membrane	protein-containing complex	synapse	vacuole

Click cells to view annotations.

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Expression Overview

GXD's primary emphasis is on endogenous gene expression during development. Click on grid cells to view annotations.

Blue cells = expressed in wild-type.
Gray triangles = other expression annotations only
(e.g. absence of expression or data from mutants).

early conceptus	embryo ectoderm	embryo endoderm	embryo mesoderm	embryo mesenchyme	extraembryonic component	alimentary system	auditory system	branchial arches	cardiovascular system	connective tissue	endocrine system	exocrine system	hemolymphoid system	integumental system	limbs	liver and biliary system	musculoskeletal system	nervous system	olfactory system	reproductive system	respiratory system	urinary system	visual system

Click cells to view annotations.

Assay Results

706
Tissues

51
cDNA Data

10
Literature Summary

40

Images

Tissue x Stage Matrix

Comparison Matrix

Gene Expression + Phenotype

Other Mouse Links

GEO

Expression Atlas
Other Vertebrate Links

Xenbase myh8

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All Sequences

52
RefSeq

4
UniProt

6
CCDS

CCDS24857.1

Ensembl

ENSMUSG00000055775 (Evidence)
NCBI Gene

17885

			Length	Strain/Species	Flank
genomic	17885	NCBI Gene Model \| MGI Sequence Detail	31511	C57BL/6J	± kb
transcript	NM_177369	RefSeq \| MGI Sequence Detail	6149	C57BL/6
polypeptide	P13542	UniProt \| EBI \| MGI Sequence Detail	1937	Not Applicable

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UniProt

6 Sequences
Protein Ontology

PR:000010832 myosin-8

(term hierarchy)
InterPro Domains

IPR014751 DNA repair protein XRCC4-like, C-terminal

IPR000048 IQ motif, EF-hand binding site

IPR036961 Kinesin motor domain superfamily

IPR001609 Myosin head, motor domain-like

IPR008989 Myosin S1 fragment, N-terminal

IPR004009 Myosin, SH3 domain

IPR002928 Myosin tail

IPR027417 P-loop containing nucleoside triphosphate hydrolase
GlyGen

P13542 1 site, 1 O-linked glycan (1 site)

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All nucleic 37

Genomic 11

cDNA 10

Primer pair 14

Other 2

Antibodies 3

Microarray probesets 3

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MGD-MRK-12758, MGD-MRK-12762, MGI:2144137, MGI:2442719, MGI:97265

Summaries

All 87

Developmental Gene Expression 40

Gene Ontology 8

Phenotypes 11
Earliest

J:137335 Roderick TH, Chromosomal inversions in studies of mammalian mutagenesis. Genetics. 1979 May;92(1 Pt 1 Suppl):s121-6
Latest

J:373583 Audu GC, et al., Gas1 regulates embryonic tongue muscle proliferation, differentiation and maturation via alternative pathways to Hedgehog signaling. Development. 2025 Oct 1;152(19)

Myh8 expression regulated by:

Feature	Feature Type	Location	Reference
Rr194, regulatory region 194	locus control region	Chr11:66994497-67036366	J:322002
Rr196, regulatory region 196	enhancer	Chr11:67010416-67012030	J:322002

TSS for Myh8:

(View these features in JBrowse)

Transcription Start Site	Location	Distance from Gene 5'-end
Tssr102221	Chr11:67167994-67168009 (+)	52 bp
Tssr102222	Chr11:67168032-67168049 (+)	91 bp
Tssr102223	Chr11:67169652-67169676 (+)	1,714 bp
Tssr102224	Chr11:67183251-67183256 (+)	15,304 bp
Tssr3530	Chr11:67183726-67183742 (+)	15,784 bp
Tssr102225	Chr11:67183755-67183772 (+)	15,814 bp
Tssr3531	Chr11:67185337-67185344 (+)	17,391 bp
Tssr102226	Chr11:67185375-67185390 (+)	17,433 bp
Tssr102227	Chr11:67189291-67189306 (+)	21,349 bp
Tssr102228	Chr11:67190153-67190191 (+)	22,222 bp
Tssr102229	Chr11:67192542-67192554 (+)	24,598 bp
Tssr102230	Chr11:67192593-67192605 (+)	24,649 bp
Tssr102231	Chr11:67196505-67196533 (+)	28,569 bp
Tssr102232	Chr11:67199395-67199422 (+)	31,459 bp

Contributing Projects: Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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