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Rgs9 Gene Detail
Summary
  • Symbol
    Rgs9
  • Name
    regulator of G-protein signaling 9
  • Synonyms
    RGS9-1, Rgs9-2
  • Feature Type
    protein coding gene
  • IDs
    MGI:1338824
    NCBI Gene: 19739
  • Alliance
    gene page
  • Transcription Start Sites
    9 TSS
Location &
Maps
more
  • Sequence Map
    Chr11:109116181-109188955 bp, - strand
    From Ensembl annotation of GRCm39
  • View this region in JBrowse
  • Genome Browsers
    Ensembl | UCSC | NCBI
  • Genetic Map
    Chromosome 11, 71.86 cM
  • Mapping Data
    4 experiments
Strain
Comparison
more
  • SNPs within 2kb
    356 from dbSNP Build 142
  • Strain Annotations
    18
  • RFLP
    1
For selected strains:
Strain Gene Model ID Feature Type Coordinates Select Strains
C57BL/6J MGI_C57BL6J_1338824
 protein coding gene Chr11:109116174-109189013 (-)
129S1/SvImJ MGP_129S1SvImJ_G0019330
 protein coding gene Chr11:112759257-112838964 (-)
A/J MGP_AJ_G0019298
 protein coding gene Chr11:107889377-107962448 (-)
AKR/J MGP_AKRJ_G0019267
 protein coding gene Chr11:111118054-111194271 (-)
BALB/cJ MGP_BALBcJ_G0019272
 protein coding gene Chr11:108322822-108395870 (-)
C3H/HeJ MGP_C3HHeJ_G0019081
 protein coding gene Chr11:111426039-111504752 (-)
C57BL/6NJ MGP_C57BL6NJ_G0019722
 protein coding gene Chr11:116176362-116259279 (-)
CAROLI/EiJ MGP_CAROLIEiJ_G0017346
 protein coding gene Chr11:105119684-105189837 (-)
CAST/EiJ MGP_CASTEiJ_G0018635
 protein coding gene Chr11:112543874-112623686 (-)
CBA/J MGP_CBAJ_G0019050
 protein coding gene Chr11:120974559-121059276 (-)
DBA/2J MGP_DBA2J_G0019162
 protein coding gene Chr11:107367388-107442959 (-)
FVB/NJ MGP_FVBNJ_G0019153
 protein coding gene Chr11:106857982-106930072 (-)
LP/J MGP_LPJ_G0019232
 protein coding gene Chr11:113176605-113252863 (-)
NOD/ShiLtJ MGP_NODShiLtJ_G0019184
 protein coding gene Chr11:120132606-120213436 (-)
NZO/HlLtJ MGP_NZOHlLtJ_G0019759
 protein coding gene Chr11:111677727-111759399 (-)
PWK/PhJ MGP_PWKPhJ_G0018400
 protein coding gene Chr11:108525868-108602707 (-)
SPRET/EiJ MGP_SPRETEiJ_G0018190
 protein coding gene Chr11:111463104-111538359 (-)
WSB/EiJ MGP_WSBEiJ_G0018686
 protein coding gene Chr11:111606650-111683807 (-)



Homology
more
  • Human Ortholog
    RGS9, regulator of G protein signaling 9
  • Vertebrate Orthologs
    4
Vertebrate Orthology Source
Alliance of Genome Resources
  • Human Ortholog
    RGS9, regulator of G protein signaling 9
  • Synonyms
    PERRS, PERRS1, RGS9L
  • Links
    NCBI Gene ID: 8787
    neXtProt AC: NX_O75916
    UniProt: O75916

  • Chr Location
    17q24.1; chr17:65100812-65227703 (+)  GRCh38
Human Diseases
more
  • Diseases
    1 with human RGS9 associations

Human Disease Mouse Models
      
IDs
Click on a disease name to see all genes associated with that disease.

Mutations,
Alleles, and
Phenotypes
less
  • Phenotype Summary
    3 phenotypes from 1 allele in 1 genetic background
    18 phenotypes from multigenic genotypes
    52 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
integument
immune system
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
neoplasm
vision/eye

Click cells to view annotations.
Mice homozygous for a targeted null mutation are viable and fertile; however, relative to wild-type, homozygous null photoreceptors display abnormally retarded recovery of their light responses, and slowed rates of GTP hydrolysis by transducin.
Gene Ontology
(GO)
Classifications
less
  • All GO Annotations
    27
  • GO References
    9
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
RNA binding
signaling receptor activity
signaling receptor binding
transcription
transferase
transporter
Biological Process

carbohydrate derivative metabolism
cell differentiation
cell population proliferation
cellular component organization
DNA-templated transcription
establishment of localization
homeostatic process
immune system process
lipid metabolic process
programmed cell death
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
non-membrane-bounded organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
protein-containing complex
synapse
vacuole
Click cells to view annotations.
Expression
less
Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
    761
  • Tissues
    34
  • cDNA Data
    55
  • Literature Summary
    6
  • Comparison Matrix
    Gene Expression + Phenotype
    • Sequences &
    Gene Models
    less
    Representative SequencesLengthStrain/SpeciesFlank
    genomic ENSMUSG00000020599 Ensembl Gene Model | MGI Sequence Detail 72775 C57BL/6J ±  kb
    transcript ENSMUST00000020920 Ensembl | MGI Sequence Detail 2434 Not Applicable  
    polypeptide ENSMUSP00000020920 Ensembl | MGI Sequence Detail 675 Not Applicable  
    For the selected sequence
    Protein
    Information
    less
    Molecular
    Reagents
    less
    • All nucleic 58
      cDNA 57
      Primer pair 1

      Microarray probesets 5
    References
    more
    • Summaries
      All 94
      Developmental Gene Expression 6
      Gene Ontology 9
      Phenotypes 52
    • Earliest
      J:53422 He W, et al., RGS9, a GTPase accelerator for phototransduction. Neuron. 1998 Jan;20(1):95-102
    • Latest
      J:319671 Liput DJ, et al., 2-Arachidonoylglycerol mobilization following brief synaptic stimulation in the dorsal lateral striatum requires glutamatergic and cholinergic neurotransmission. Neuropharmacology. 2022 Mar 1;205:108916
    Contributing Projects:
    Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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    Funding Information
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    Send questions and comments to User Support.     		last database update
    04/09/2024
    MGI 6.23     		The Jackson Laboratory