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Cyp8b1 Gene Detail
Summary
  • Symbol
    Cyp8b1
  • Name
    cytochrome P450, family 8, subfamily b, polypeptide 1
  • Synonyms
    sterol 12-alpha-hydrolase
  • Feature Type
    protein coding gene
  • IDs
    MGI:1338044
    NCBI Gene: 13124
  • Alliance
    genome feature page
  • Transcription Start Sites
    4 TSS
Location &
Maps
more
  • Sequence Map
    Chr9:121743422-121745371 bp, - strand
    From NCBI annotation of GRCm39
  • View this region in JBrowse
  • Genome Browsers
    Ensembl | UCSC | NCBI
  • Genetic Map
    Chromosome 9, 72.73 cM, cytoband F4
  • Mapping Data
    3 experiments
Strain
Comparison
more
  • SNPs within 2kb
    137 from dbSNP Build 142
  • Strain Annotations
    19
For selected strains:
Strain Gene Model ID Feature Type Coordinates Select Strains
C57BL/6J MGI_C57BL6J_1338044
 protein coding gene Chr9:121743422-121745371 (-)
129S1/SvImJ ENSMUSG00200027862
 protein coding gene Chr9:118864024-118865973 (-)
A/J ENSMUSG00195024715
 protein coding gene Chr9:118028166-118030115 (-)
AKR/J ENSMUSG00220018556
 protein coding gene Chr9:118482428-118484377 (-)
BALB/cJ ENSMUSG00180023594
 protein coding gene Chr9:118565174-118567123 (-)
C3H/HeJ ENSMUSG00175018898
 protein coding gene Chr9:118808580-118810529 (-)
C57BL/6NJ ENSMUSG00215025984
 protein coding gene Chr9:118696394-118698343 (-)
CAROLI/EiJ MGP_CAROLIEiJ_G0032836
 protein coding gene Chr9:117280986-117282935 (-)
CAST/EiJ ENSTCUG00005016320
 protein coding gene Chr9:118416076-118418025 (-)
CBA/J ENSMUSG00210037442
 protein coding gene Chr9:118521198-118523147 (-)
DBA/2J ENSMUSG00185014757
 protein coding gene Chr9:118855423-118857372 (-)
FVB/NJ ENSMUSG00205017882
 protein coding gene Chr9:118696898-118698847 (-)
JF1/MsJ ENSUMUG00000039818
 protein coding gene Chr9:118683184-118685133 (-)
LP/J ENSMUSG00230035829
 protein coding gene Chr9:119003142-119005091 (-)
NOD/ShiLtJ ENSMUSG00190014610
 protein coding gene Chr9:118460342-118462291 (-)
NZO/HlLtJ ENSMUSG00225023318
 protein coding gene Chr9:119267412-119269361 (-)
PWK/PhJ ENSLUMG00010032047
 protein coding gene Chr9:118570849-118572797 (-)
SPRET/EiJ ENSMSPG00010022289
 protein coding gene Chr9:120282505-120284454 (-)
WSB/EiJ ENSIUOG00005018951
 protein coding gene Chr9:117888918-117890867 (-)



Homology
more
  • Human Ortholog
    CYP8B1, cytochrome P450 family 8 subfamily B member 1
  • Vertebrate Orthologs
    4
Vertebrate Orthology Source
Alliance of Genome Resources
  • Human Ortholog
    CYP8B1, cytochrome P450 family 8 subfamily B member 1
  • Synonyms
    CP8B, CYP12, CYPVIIIB1
  • Links
    NCBI Gene ID: 1582
    UniProt: Q9UNU6

  • Chr Location
    3p22.1; chr3:42856005-42875898 (-)  GRCh38
Mutations,
Alleles, and
Phenotypes
less
  • Phenotype Summary
    8 phenotypes from 1 allele in 1 genetic background
    17 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
integument
immune system
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
neoplasm
vision/eye

Click cells to view annotations.
Mice homozygous for a knock-out allele lack synthsesis of cholate (a primary bile acid) and its metabolites and display an increased bile acid pool and alterations in cholesterol metabolism.
Gene Ontology
(GO)
Classifications
less
  • All GO Annotations
    21
  • GO References
    11
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
RNA binding
signaling receptor activity
signaling receptor binding
transcription
transferase
transporter
Biological Process

carbohydrate derivative metabolism
cell differentiation
cell population proliferation
cellular component organization
DNA-templated transcription
establishment of localization
homeostatic process
immune system process
lipid metabolic process
programmed cell death
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
membraneless organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
protein-containing complex
synapse
vacuole
Click cells to view annotations.
Expression
less
Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
    705
  • Tissues
    106
  • cDNA Data
    26
  • Literature Summary
    6
  • Comparison Matrix
    Gene Expression + Phenotype
    • Sequences &
    Gene Models
    less
    Representative SequencesLengthStrain/SpeciesFlank
    genomic 13124 NCBI Gene Model | MGI Sequence Detail 1950 C57BL/6J ±  kb
    transcript NM_010012 RefSeq | MGI Sequence Detail 1950 ZRU/MplStud  
    polypeptide O88962 UniProt | EBI | MGI Sequence Detail 500 Not Applicable  
    For the selected sequence
    Protein
    Information
    less
    Molecular
    Reagents
    less
    • All nucleic 29
      Genomic 1
      cDNA 26
      Primer pair 2

      Microarray probesets 3
    References
    more
    • Summaries
      All 54
      Developmental Gene Expression 6
      Gene Ontology 11
      Phenotypes 17
    • Earliest
      J:53496 Gafvels M, et al., Structure and chromosomal assignment of the sterol 12alpha-hydroxylase gene (CYP8B1) in human and mouse: eukaryotic cytochrome P-450 gene devoid of introns. Genomics. 1999 Mar 1;56(2):184-96
    • Latest
      J:389099 Lin H, et al., The enterohepatic bile acid axis: from perinatal programming to metabolic collapse. Biochem Biophys Res Commun. 2026 Jul 9;830:154261
    Contributing Projects:
    Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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    Funding Information
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    Send questions and comments to User Support.     		last database update
    09/08/2026
    MGI 6.24     		The Jackson Laboratory