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Phf2 Gene Detail
Summary
  • Symbol
    Phf2
  • Name
    PHD finger protein 2
  • Feature Type
    protein coding gene
  • IDs
    MGI:1338034
    NCBI Gene: 18676
  • Alliance
    genome feature page
  • Transcription Start Sites
    13 TSS
Location &
Maps
more
  • Sequence Map
    Chr13:48955226-49024361 bp, - strand
    From NCBI annotation of GRCm39
  • View this region in JBrowse
  • Genome Browsers
    Ensembl | UCSC | NCBI
  • Genetic Map
    Chromosome 13, 24.96 cM, cytoband A3-A4
  • Mapping Data
    1 experiment
Strain
Comparison
more
  • SNPs within 2kb
    1621 from dbSNP Build 142
  • Strain Annotations
    19
For selected strains:
Strain Gene Model ID Feature Type Coordinates Select Strains
C57BL/6J MGI_C57BL6J_1338034
 protein coding gene Chr13:48955226-49024595 (-)
129S1/SvImJ ENSMUSG00200035522
 protein coding gene Chr13:46234024-46303396 (-)
A/J ENSMUSG00195028830
 protein coding gene Chr13:45283598-45352979 (-)
AKR/J ENSMUSG00220009214
 protein coding gene Chr13:45094506-45163721 (-)
BALB/cJ ENSMUSG00180008455
 protein coding gene Chr13:45585882-45655254 (-)
C3H/HeJ ENSMUSG00175028387
 protein coding gene Chr13:45556358-45625732 (-)
C57BL/6NJ ENSMUSG00215006187
 protein coding gene Chr13:45702920-45772298 (-)
CAROLI/EiJ MGP_CAROLIEiJ_G0018495
 protein coding gene Chr13:44043145-44110771 (-)
CAST/EiJ ENSTCUG00005029857
 protein coding gene Chr13:45616059-45685566 (-)
CBA/J ENSMUSG00210026697
 protein coding gene Chr13:45561724-45631103 (-)
DBA/2J ENSMUSG00185029964
 protein coding gene Chr13:46375757-46445134 (-)
FVB/NJ ENSMUSG00205010040
 protein coding gene Chr13:45338735-45408035 (-)
JF1/MsJ ENSUMUG00000009744
 protein coding gene Chr13:45904424-45974215 (-)
LP/J ENSMUSG00230028376
 protein coding gene Chr13:55696585-55765954 (-)
NOD/ShiLtJ ENSMUSG00190011697
 protein coding gene Chr13:45780622-45850002 (-)
NZO/HlLtJ ENSMUSG00225035738
 protein coding gene Chr13:49446962-49516328 (-)
PWK/PhJ ENSLUMG00010020123
 protein coding gene Chr13:44759721-44829105 (-)
SPRET/EiJ ENSMSPG00010027634
 protein coding gene Chr13:44888416-44957624 (-)
WSB/EiJ ENSIUOG00005027151
 protein coding gene Chr13:44917733-44987082 (-)



Homology
more
  • Human Ortholog
    PHF2, PHD finger protein 2
  • Vertebrate Orthologs
    3
Vertebrate Orthology Source
Alliance of Genome Resources
  • Human Ortholog
    PHF2, PHD finger protein 2
  • Synonyms
    CENP-35, GRC5, JHDM1E, KDM7C
  • Links
    NCBI Gene ID: 5253
    UniProt: O75151

  • Chr Location
    9q22.31; chr9:93576584-93679599 (+)  GRCh38
Mutations,
Alleles, and
Phenotypes
less
  • Phenotype Summary
    13 phenotypes from 2 alleles in 2 genetic backgrounds
    1 phenotype from multigenic genotypes
    9 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
integument
immune system
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
neoplasm
vision/eye

Click cells to view annotations.
Mice homozygous for a knock-out allele exhibit partial postnatal lethality, decreased body weight, decreased adipocity and impaired adipogenesis.
Gene Ontology
(GO)
Classifications
less
  • All GO Annotations
    42
  • GO References
    9
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
RNA binding
signaling receptor activity
signaling receptor binding
transcription
transferase
transporter
Biological Process

carbohydrate derivative metabolism
cell differentiation
cell population proliferation
cellular component organization
DNA-templated transcription
establishment of localization
homeostatic process
immune system process
lipid metabolic process
programmed cell death
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
membraneless organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
protein-containing complex
synapse
vacuole
Click cells to view annotations.
Expression
less
Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
    748
  • Tissues
    149
  • cDNA Data
    10
  • Literature Summary
    9
  • Comparison Matrix
    Gene Expression + Phenotype
    • Sequences &
    Gene Models
    less
    Representative SequencesLengthStrain/SpeciesFlank
    genomic 18676 NCBI Gene Model | MGI Sequence Detail 69136 C57BL/6J ±  kb
    transcript NM_011078 RefSeq | MGI Sequence Detail 5260 ZRU/MplStud  
    polypeptide Q9WTU0 UniProt | EBI | MGI Sequence Detail 1096 Not Applicable  
    For the selected sequence
    Protein
    Information
    less
    Molecular
    Reagents
    less
    • All nucleic 13
      Genomic 1
      cDNA 10
      Primer pair 2

      Microarray probesets 2
    References
    more
    • Summaries
      All 49
      Developmental Gene Expression 9
      Gene Ontology 9
      Phenotypes 9
    • Earliest
      J:182573 Roderick TH, Producing and detecting paracentric chromosomal inversions in mice. Mutat Res. 1971 Jan;11(1):59-69
    • Latest
      J:351081 Fukushima T, et al., PHF2 regulates sarcomeric gene transcription in myogenesis. PLoS One. 2024;19(5):e0301690
    Contributing Projects:
    Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
    Citing These Resources
    Funding Information
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    Send questions and comments to User Support.     		last database update
    09/15/2026
    MGI 6.29     		The Jackson Laboratory